|Home | About | Journals | Submit | Contact Us | Français|
Following the publication of this article , the authors were made aware that the aberrant seminiferous tubules shown in Fig 3B look like invasive cribriform growth of the caput epididymal epithelium into the testis. The legend for Fig 3 has been updated to include this information, and a new supporting figure (S7 Fig) can be viewed below. Staining with GNCA failed to detect germ cells in these tubules, and subsequent clusterin staining (S7 Fig) is consistent with the presence of epididymal principal cells. Because disruption of estrogen signaling has been reported to elicit cribriform growth and granulomas in the epididymis and aberrant growth into the efferent ducts (reviewed in ), the rare tubules observed in this otherwise fibrotic testis appear to be the result of extreme disruption of estrogen-regulation of epididymal physiology.
Histological section of fibrotic testis from EEE male stained with an antibody to clusterin (brown), a marker of epididymal principal cells. Scale bar denotes 50 µm.