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Logo of neuroscibullNeuroscience Bulletin
Neurosci Bull. 2008 February; 24(1): 49–55.
Published online 2008 February 27. doi:  10.1007/s12264-008-0808-9
PMCID: PMC5552524

Language: English | Chinese

Molecular control of memory in nematode Caenorhabditis elegans



Model invertebrate organism Caenorhabditis elegans has become an ideal model to unravel the complex processes of memory. C. elegans has three simple forms of memory: memory for thermosensation, memory for chemosensation, and memory for mechanosensation. In the form of memory for mechanosensation, short-term memory, intermediate-term memory, and long-term memory have been extensively studied. The short-term memory and intermediate-term memory may occur in the presynaptic sensory neurons, whereas the long-term memory may occur in the postsynaptic interneurons. This review will discuss the recent progress on genetic and molecular regulation of memory in C. elegans.

Keywords: memory, molecular mechanism, Caenorhabditis elegans, model invertebrate organism


模式无脊椎动物秀丽线虫已经成为揭示记忆复杂行为的理想研究模型之一。 线虫具有三种简单的记忆形式: 对温度感知的记忆、 对化学物质感知的记忆以及对于机械刺激感知的记忆。 在对机械刺激感知的记忆研究中, 短时程、 中时程与长时程记忆均得到了系统的分析。 其中短时程与中时程记忆可能定位于感觉神经元的前突触, 而长时程记忆可能定位于中间神经元的后突触。 本文针对线虫中记忆的遗传与分子调控机制近些年的研究进展进行了总结与讨论。

关键词: 记忆, 分子机制, 秀丽线虫, 无脊椎模式动物


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