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Our previous work suggested that sensitivity of hippocampal neurons is changed in process of epileptic activities, and closely parallel to the dynamic characteristic of epileptic activity of the neurons. This study investigated the sensitivity of epileptic brain to vagal nerve stimulation (VNS) in epileptic process.
Epileptic model was evoked by penicillin. Left vagal nerves were stimulated to inhibit the seizures induced by penicillin. The electrocorticography (ECoG) and electromyography (EMG) were recorded to analyze inhibiting effect of VNS in epileptic process.
It was found that VNS could inhibit the seizures caused by penicillin, and the inhibiting effect of VNS to seizures increased as the vagal nerve stimulating time prolonged. It was also found that the inhibiting effect of VNS to seizures decreased in epileptic process.
The results suggested that the sensitivity of epileptic brain to VNS was different in epileptic process. The inhibiting effect of VNS to seizure decreased as the development of seizures.
我们以前的研究发现大鼠海马神经元对刺激的敏感性在癫痫发作过程中是变化的, 并且与神经电活动的非线性动力学特征密切相关。 本研究观察在癫痫发作过程中迷走神经刺激(vagal nerve stimulation, VNS)对癫痫的抑制作用。
在青霉素诱导的大鼠癫痫模型上, 通过记录皮层脑电图和下肢肌电图观察癫痫发作情况, 电刺激左侧颈部迷走神经, 观察 VNS 对癫痫的抑制作用。
VNS 对癫痫活动有明显的抑制作用, 其抑制作用随着刺激时间的延长而增加; 同时发现 VNS 对癫痫的抑制作用在癫痫发作过程是不同的, 癫痫发作开始阶段 VNS 的抑制作用较强, 随着癫痫发作的发展, 其抑制作用逐渐减弱。
大鼠癫痫发作过程中大脑对 VNS 的敏感性是不同的, 随着癫痫的发展, VNS 对癫痫的抑制作用逐渐减弱。