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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
 
J Biophotonics. Author manuscript; available in PMC 2017 August 9.
Published in final edited form as:
PMCID: PMC5550318
NIHMSID: NIHMS882210

Evaluation of the 2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide (HPPH) mediated photodynamic therapy by macroscopic singlet oxygen modeling

[J. Biophotonics 9, No. 11–12, 1344–1354 (2016)]

In the article by R. Penjweini, M.M. Kim, et al. (doi: 10.1002/jbio.201600121), published in J. Biophotonics 9, 1344–1354 (2016), the constants C01, C02, b1, and b2 determined from fitting the fluorescence single value decomposition (SVD) for phantoms with different optical properties and the corresponding Figure 2(a) are not correct. This erratum is published to correct the section 2.3 and Figure 2(a).

Figure 2
(a) Fluorescence single value decomposition (SVD) amplitude for phantom experiments with different optical properties with the same HPPH concentration.

The “Measurements of the HPPH concentration prior to and post PDT” in section 2.3 and Figure 2(a) should read:

The attenuation of HPPH fluorescence signal due to the light absorption and scattering by tissue was corrected by applying an empirical correction factor (CF) of the following form [16, 18, 31]:

CF=C01+C02μsμs·exp[(b1+b2μs)·3μaμs]
(1)

where C01, C02, b1, and b2 are constants (0.469, 0.0543, 0.657, and −0.0193 respectively) determined from fitting the fluorescence SVD for phantoms with different optical absorption coefficients, μa and optical reduced scattering coefficients, μs’. The correction factor is specific to the probe and semi-infinite geometry setup used for the measurements.

Acknowledgments

This work is supported by grants from the National Institute of Health (NIH) R01 CA154562 and P01 CA87971.