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Curr Hypertens Rep. Author manuscript; available in PMC 2017 August 7.
Published in final edited form as:
PMCID: PMC5546311
NIHMSID: NIHMS888450

Hypertension is a key feature of the metabolic syndrome in subjects aging with HIV

Abstract

With widespread and effective antiretroviral therapy, the life expectancy in the HIV population has dramatically improved over the last two decades. Consequently, as patients are aging with HIV, other age-related comorbidities, such as metabolic disturbances and cardiovascular disease (CVD), have emerged as important causes of morbidity and mortality. An overrepresentation of traditional cardiovascular risk factors (RF), toxicities associated with long exposure to antiretroviral therapy, together with residual chronic inflammation and immune activation associated with HIV infection are thought to predispose to these metabolic complications and to the excess risk of CVD observed in the HIV population.

The metabolic syndrome (MS) represents a clustering of RF for CVD that includes abdominal obesity, hypertension, dyslipidemia, and insulin resistance.

Hypertension is a prevalent feature of the MS in HIV, in particular in the aging population, and constitutes an important RF for CVD.

Physicians should screen their patients for metabolic and cardiovascular risk at the regular visits to reduce MS and the associated CVD risk among people aging with HIV, since many of RF are under-diagnosed and under-treated conditions.

Interventions to reduce these RF can include life-style changes and pharmacological interventions such as antihypertensive and lipid-lowering therapy, and treatment of glucose metabolism disturbances. Changes in antiretroviral therapy to more metabolic neutral antiretroviral drugs may also be considered.

Keywords: Metabolic syndrome, antiretroviral therapy, cardiovascular risk, HIV infection, hypertension

Introduction

With the wide availability of potent and well-tolerated highly active antiretroviral therapy (HAART) the HIV-infected population have experienced a dramatic improvement in life expectancy. Consequently, people aging with HIV are now facing age-related comorbidities and antiretroviral (ARV)-related complications such as metabolic disturbances, renal impairment, osteopenia/osteoporosis, neurocognitive impairment, atherosclerosis and cardiovascular disease (CVD).

The long-term exposure to ARV drugs, the chronic inflammation and immune activation associated with HIV infection, even if successfully treated, together with an overrepresentation of some traditional CVD risk factors (RF) in the HIV-infected individuals, predispose to different morphological and metabolic disturbances, including the features included in the metabolic syndrome (MS), which probably in part explains the increased risk of CVD described in the HIV-infected population.

The MS definition, developed for the general population, is used to describe a clustering of RF for CVD that includes abdominal obesity, hypertriglyceridemia, low high-density lipoprotein (HDL) cholesterol, hyperglycaemia and insulin resistance (IR) and hypertension (HTA), and constitutes an important RF for the subsequent progression towards diabetes, atherosclerosis and CVD [1].

The MS shares some of these metabolic disturbances with the lipodystrophy syndrome (LDS) observed in some HIV-infected patients, which consists of a complex syndrome of fat redistribution with peripheral lipoatrophy and central lipohypertrophy, often together with metabolic and endocrine disorders as dyslipidaemia and IR.

Several definitions of MS have been developed (table 1), which makes comparison between studies difficult. The most widely used are the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) and the International Diabetes Federation (IDF). The NCEP ATP-III requires the presence of 3 or more of 5 features of the definition. The definition was recently revised in 2005 to include lipid lowering and antihypertensive therapy as part of the criteria and reduced cut-off for serum glucose [2]. In the IDF definition abdominal obesity is an essential criterion for establishing the diagnosis and includes both gender and race specific cut-offs for waist circumference (WC)[3]. However, a recent consensus between the American Heart Association/National Heart, Lung and Blood Institute (AHA/NHLBI) and IDF have elaborated the AHA/NHLBI definition of the MS not including central obesity as a prerequisite [4].

Table 1
Main work definitions for the metabolic syndrome

Diagnosis, prevention and management of these modifiable RF are of pivotal importance in order to reduce progression of the atherosclerotic process and CVD risk in this population. In this article we review the recent literature on MS in the HIV-infected population and its clinical implications. We used for the purpose a systematic search in the literature using PubMed. The incorporating criteria were “Metabolic syndrome“, “HIV infection”, “Hypertension”, “Diabetes mellitus” and “Cardiovascular disease”.

Prevalence and predictors of the metabolic syndrome in HIV-infected populations

According to recent data from National Health and Nutrition Examination Survey (NHANES), the overall age-adjusted prevalence of MS in U.S. adults is increasing and between 2007–2010 was 34.3% [5]. However, lower prevalence rates are reported in European countries, ranging from 6–30% [69]. The real prevalence of MS among HIV-infected individuals is still of debate, with many observational studies reporting very wide-range estimates from 7–52% (table 2)[1052]. These large differences are probably due to differences in study design, most being cross-sectional with small study groups, different population characteristics, and differences in the definition of MS applied, making it difficult to conclusively establish if the prevalence in individuals living with HIV-infection is comparable to that seen in the general population. However, two US studies observed similar MS prevalence rates in HIV-infected and HIV-uninfected individuals from the NHANES matched for age, sex, and race [14,25].

Table 2
Prevalence studies of the metabolic syndrome in the HIV population

Despite these limitations, an increasing prevalence of MS with increasing age has uniformly been observed in different study populations [15,18,20,25,26,2830,3537,39,53,54]. In the Data-collection on Adverse effects of antiretroviral Drugs (D:A:D) study, prospectively following 33347 HIV-infected individuals at 212 clinics in Europe, Australia and the U.S., an increasing prevalence of MS was reported over time, from 19.4% in 2000–2001 to 41.6% in 2006–2007, partly due to aging of the cohort and growing awareness among physicians. Among those with MS, the majority had hypertriglyceridemia, low HDL-cholesterol and HTA (Table 3) [24]. MS prevalence also varies with gender and ethnicity. Few studies describe significantly higher rates of MS in women [30,36,43], whereas others report similar or higher prevalence in men [25,39]. In the latter, however, women developed MS at younger age, were more likely to be African American, less likely to be on ARV and had a higher BMI, central obesity and lower triglycerides (TG) compared to HIV-infected men with MS [25,39]. One US study including only women (1725 seropositive and 668 seronegative), found a significantly higher prevalence of MS in the HIV-infected group (33% vs. 22%, OR 1.79, 1.48–2.16)[20].

Table 3
Distribution of metabolic syndrome components among HIV-infected patients with metabolic syndrome.

Regarding ethnic differences, data from NHANES showed that the prevalence of MS in the general adult population was lower among African American men than White or Mexican American men, and lower among White women than among African American or Mexican American women [55]. Mondy et al. reported similar findings, with HIV-infected women with MS more likely to be African American with high prevalence of obesity, whereas men with MS were more likely to be White [25]. In contrast, MS was less prevalent among African American HIV-infected women than among White or Hispanic HIV-infected women in another recent study (31%, 42% and 34%, respectively, p 0.030) in which the MS diagnosis was mainly driven by high TG and low HDL-cholesterol levels [20]. However, most studies in HIV-infected individuals include mainly males and small proportion of minorities, making it difficult to draw clear conclusions on the impact of gender and ethnicity in the development of MS in this population.

The D:A:D study further explored the impact of applying the various definitions of MS, highlighting the difficulties assessing the MS in observational studies due to potential bias, missing data and measurement variability [24]. These difficulties were also revealed in another recent study reporting significantly higher prevalence rates of MS when applying the European Group for the Study of Insulin Resistance (EGIR) definition which requires insulin measuring and has lower thresholds for abdominal obesity, pointing at the central role of IR in the development of MS [45].

Abdominal obesity and sedentary lifestyle are key components in the development of the MS in the general population and also observed in HIV-infected populations, although there are notable differences in specific constituents of the MS [14,25,28,35,37,39,5658]. HIV-infected individuals are more likely to have a lower BMI and a smaller waist circumference (WC) and waist-to-hip ratio than the HIV-uninfected individuals [25,27]. However, high prevalence of obesity is described among some groups of HIV-infected individuals, reflecting the epidemic rates of obesity also observed in the general population [25,51].

Changes in fat mass or adipocyte function are strongly associated with MS [14,18,22,54]. Lypodistrophy (LDS) is associated with HIV infection and ARV, especially thymidine analogues and older PI, and was more prevalent in earlier studies [59]. LDS is usually associated with IR, dyslipidemia and increased risk of CVD[43]. The body fat disturbances found in these patients might imply underdiagnosis of MS as they may have a low or normal BMI and low WC [43], not meeting the anthropometric MS criteria. Since individuals infected with HIV have increased visceral fat despite lower WC some has proposed different anthropometric cut-offs for HIV-infected persons [60]. One study showed that individuals with LDS meeting the MS criteria were at higher risk of CVD than those with LDS without MS [43]. ARV-induced mitochondrial toxicity, altered adipokine secretion and activity, hypoadiponectinemia and leptin deficiency, increased levels of inflammatory and prothrombotic makers such as CRP, TNF-alfa, IL6 and PAI-I, alterations in lipid metabolism with increased circulating free-fatty acids and reduced lipid storage ability resulting in IR, are some of the proposed underlying mechanisms [6163].

Interestingly, a recent cohort study found that 37% of HIV-positive naïve individuals with MS at baseline no longer met MS criteria after 96 weeks of ARV, experiencing improvement in their metabolic profiles, especially in HDL and WC after cART initiation [58]. These data suggest the possible impact of the virus itself in the pathogenesis of MS.

The features of MS in the HIV-infected individuals differ from those in the general population, with HTA, hypertriglyceridemia and low HDL-cholesterol constituting the most prevalent components (Table 3), whereas in the general population abdominal obesity is a major driver [25,29,36]. These differences might be attributed to the pathogenic contribution of the HIV infection and the metabolic effects of ARV in the development of MS in the HIV-population.

Hypertension in HIV-related MS

Hypertension is common among HIV-infected people with prevalence ranging from 4–54% [21,25,6467], and as high as 96% among HIV-infected persons with MS in some studies (Table 3) [24,27,38,40,58]. HTA is a key feature of MS in HIV-infected patients, and an important RF for CVD in this population [25].

Some studies have found a higher HTA prevalence in HIV patients compared to HIV-uninfected individuals [6870], whereas other studies have reported comparable estimates [25,27,71,72]. Similar to findings in the general population, identified predisposing factors for HTA in HIV patients includes older age, male gender, African-American or African-Caribbean ethnicity, higher BMI, central obesity, previous CV events, chronic kidney disease, family story of HTA and CVD, diabetes, dyslipidemia, MS and LDS [29,7379]. It is thought that both HIV infection and exposure to ARV, especially duration of the exposure, through metabolic disturbances and endothelial damage might have an additional role in development of HTA in HIV patients. In the Multicenter AIDS Cohort Study (MACS) higher prevalence of systolic HTA was found in individuals on HAART for more than 2 year than HIV-infected men on HAART for less than 2 years or HIV-uninfected men after adjusting for age, race, BMI, and smoking [64]. In a Norwegian study the lowest prevalence of HTA was observed in HIV patients on cART for less than 2 years, observing a continuous increase in the prevalence from 23% in those treated for less than 2 years to 44% in those treated with cART for more than 5 years [66]. Similarly, finding from the D:A:D revealed increases in blood pressure (BP) over the first 2.3 years following cART initiation, although no independent deleterious effect of any specific ARV class was observed [67].

Findings from a recent Italian cross-sectional study assessing 1182 unselected consecutive HIV patients from outpatient clinics found that duration of HIV infection, CD4 T-cell count < 200/μl and duration of ARV were independently associated with HTA [74]. Similar findings are reported from recent studies from Uganda and Tanzania finding that lower nadir CD4 T-cell count and ARV were associated with HTA [70,80].

In a recent systematic review with meta-analysis including 30 cross-sectional and 9 cohort studies, exposure to ARV was significantly associated with higher mean systolic and diastolic BP and with increased risk of HTA in ARV-treated compared to ARV-naïve HIV-infected subjects (14.5% vs 10.5%, OR 1.68, 1.35–2.10) [81]. However, other studies have not found association of ARV and HTA [35,71,82].

Hypertension is associated with an increased risk of CVD, including AMI and stroke in HIV-infected as in the general populations [83]. Findings from the Veterans Aging Cohort Study Virtual Cohort (VACS-VC) prospectively following 27059 HIV-positive veterans who are matched by age, gender, ethnicity, clinical site and calendar year to HIV-uninfected veterans, found that HIV, prehypertension and HTA were associated with an increased risk of AMI. AMI risk increased with increasing BP in both HIV-infected and –uninfected veterans. However, AMI rates were significantly higher among HIV-infected veterans with HTA compared to HIV-uninfected veterans with HTA (aHR 2.57, 1.76–3.76 vs 1.47, 1.02–2.11), as well as in those on antihypertensive medication (aHR 2.76, 1.90–4.02 vs 1.92, 1.35–2.72). A 10mmg Hg increase in pulse pressure was associated with a 12% increased risk of AMI (HR 1.12, 1.06–1.19)[84].

Similarly, in the Swiss HIV Cohort Study assessing 2595 patients with HTA found that a 10 mm Hg increases in systolic BP was associated with a HR of 1.18 (1.06–1.32) of CV events [65].

Pre-diabetes in HIV-related MS

The prevalence of glucose metabolism disorders is an increasing condition among HIV-infected individuals. Markers of IR and increased glucose levels fulfilling criteria for pre-diabetes are included in the MS definitions (Table 1). Reported rates of pre-diabetes in HIV infected persons are ranging from 6–59%, and highly dependent on the applied screening methods (Table 3).

The prevalence of overt diabetes in HIV-infected subjects have been reported in some studies to be two-four fold increased than in healthy subjects[8587], however, this excess risk has not been confirm in other studies [8890]. A recent large study from the South Carolina Medicaid system, reported lower diabetes incidence in the HIV-group compared to HIV-uninfected controls in the latest period from 2004–2011 [88]. Similarly, the Danish HIV Cohort Study found no increased risk of diabetes compared to population-based matched controls in the latest period 1999–2010 [89]. The availability of newer ARV drugs with better metabolic profile could partly explain this difference, which is likely also related to genetic, demographic, dietary and other differences between study populations.

In addition to traditional RF for the development of diabetes including male gender, older age, BMI, African or Asian ethnicity, other HIV-related factors such as ARV (particularly exposure to older PI and thymidine analogues) and LDS are predictors of diabetes [41,9092]. The D:A:D Study Group found that higher TG levels and low HDL were independently predictive of the development of diabetes[92].

The cardiovascular risk associated with MS

Occurrence of MS in the general population is associated with two-fold increased risk of CVD and in those without diabetes with a five-fold increase risk for development of diabetes [93].

Most studies of CVD risk in HIV-infected adults with MS have utilized surrogate measures of subclinical atherosclerosis through arterial imaging, which are independent predictors of CVD. A cross-sectional study investigated carotid intima-media thickness (c-IMT) and coronary artery calcium (CAC) scores, in 314 HIV-infected patients, 22.9% fitting the criteria for having MS. Persons with MS were more likely to have an abnormal common c-IMT measurement (OR 2.9, p= 0.020) and detectable CAC scores (OR 4.9, p< 0.0001)[30]. Another recent study found presence of CAC more common among HIV-infected patients with MS compared to HIV-uninfected controls [94]. Maloberti et al. explored arterial stiffness measured by aorto-femoral pulse wave velocity (PWV) and found that PWV was significantly greater in individuals with MS on HAART compared to HIV-infected individuals without MS on HAART or with HIV-uninfected controls both with and without MS [44]. Of note, treatment with metformin has been shown to prevent progression of CAC and calcified plaque volume in HIV patients with MS [95].

Nonetheless, although few studies have explored the predictive value of MS on CVD outcome, an increased risk of cardiovascular events has been observed among patients with MS. In the D:A:D study, a strong positive correlation between increasing number of the components of the MS and CVD risk in HIV individuals was observed. The risk of CVD among patients with MS at study entry was almost 3-fold higher (RR 2.89, 2.34–3.59) compared to those without MS, with a median follow-up of 5.1 person-years (3.2–6.5) and adjusting for age, sex, family history of CVD, smoking, calendar year and ARV exposure. The rate of CVD increased by 46% for each additional component (RR 1.46, 1.34–1.58) after adjustment for potential confounders. Diabetes was the strongest predictor of CVD (RR 2.31; 95% CI 1.83–2.92), while the presence of HTA was associated with a 26% increased risk of CVD (RR 1.26, 0.98–1.62). However, the correlation between MS and risk of CVD disappeared after adjusting for each of the individual components of the MS, with no evidence of synergistic effect between individual RF. These findings might suggest that the presence of MS as such in HIV-infection does not confer an extra CVD risk beyond its individual components [23].

The INITIO trial followed 881 HIV infected adults initiating HAART with thymidine analogues and efavirenz or/and nelfinavir for 3 years, and found that the presence of MS at baseline was associated with CVD without reaching statistical significance. However, incident MS during the study period was significantly associated with the development of CVD (HR 2.73, 95%CI 1.07–6.96). MS predicted CVD even more strongly than the Framingham Risk Score [15].

A recent study explored the impact of MS on all-cause mortality in 567 HIV-infected individuals and found that MS and high TG were both significantly associated with an increased risk of death after 36 months of follow-up (aHR 2.31 and 3.97, respectively) [96].

The role of antiretroviral therapy in the metabolic syndrome

In addition to genetic predisposition and lifestyle factors, ARV-related metabolic side effects and the HIV infection itself might play an important role in the pathogenesis of MS in HIV-infected patients.

As mentioned above, HAART initiation might contribute to an improvement in the metabolic profile in naïve HIV-infected patients [58] and the results from SMART study demonstrated its benefits in overall mortality and CVD[97,98].

However, some ARV drugs, and in particular PIs, can induce diverse metabolic disturbances like proatherogenic dyslipidaemia, lipodystrophic body changes (especially thymidine analogues and older PI), impaired insulin sensitivity, adipocyte injury with altered adipocytokines secretion, vascular inflammation and endothelial dysfunction. Some retrospective studies have found a higher prevalence of MS associated with exposure to HAART [13,18,31,39] and in particular with older PIs [14,18,19,31,34,36,38,39,42,51,99] and thymidine analogues [14,19,33,42], however this has not been confirmed in other studies [12,15,16,20,25,27,29].

Specific PIs like lopinavir/ritonavir and indinavir have been associated with MS [14,19,34,100,101]. It is not clear if this association is also applicable for newer PI as darunavir and atazanavir with a more favourable metabolic profile [33,52]. Recent results from the Swiss HIV Cohort Study revealed that individuals exposed to atazanavir were less likely to develop MS [33]. Similarly, in the D:A:D analysis, atazanavir was not associated with acute myocardial infarction (AMI) or stroke. Data on darunavir are not yet available [102].

There are concerns about abacavir exposure and increased risk of AMI, although a causal relationship has not been confirmed [103]. The metabolic profile of abacavir is not unfavourable and the AMI risk associated with abacavir has been observed relatively soon after drug exposure. Proposed underlying mechanisms include platelet dysfunction and altered endothelial function. However, studies examining markers of endothelial function, coagulation and inflammation have not provided clear results.

Hypertriglyceridemia is generally less prevalent with NNRTI-regimens compared to PI-based regimens. Although efavirenz exposure was associated with MS in one recent cross-sectional study, nevirapine has been associated with safer lipid profile with increases in HDL-cholesterol [104,105] and lower prevalence of MS [29].

The role of HIV infection in the metabolic syndrome

HIV infection is associated with chronic inflammation and immune dysfunction even in virologically suppressed patients. Contributing factors to this residual inflammation includes microbial translocation, immune reactivation and immune senescence [106]. This may lead to changes in lipid metabolism, altered thrombosis and endothelial dysfunction.

The role of inflammation and hypercoagulation in the pathogenesis of MS, DM and atherosclerosis is well established in the general population and in the HIV-infected population [61,93,107]. In a number of studies, inflammatory markers such as hsCRP and IL-6 were increased in HIV-infected patients with MS compared to those without MS, and these markers have been identified as independent predictors of atherosclerosis and CVD also in the HIV population [18,34,108].

Uncontrolled HIV replication is a significant independent predictor of dyslipidemia with low levels of total cholesterol, low-density lipoprotein (LDL)- and HDL-cholesterol and increased levels of TG [109111]. This is consistent with the findings from the SMART study, where in the ARV-interruption arm was observed an increased in TC/HDL ratio, decreases in HDL and increases in IL-6 levels observed in relation to increase in HIV-RNA [104]. HIV infection and chronic inflammation is associated with hypoalphalipoproteinemia, altered HDL metabolism redirecting cholesterol to apo-B containing lipoproteins resulting in predominance of very-low-density lipoprotein (VLDL)-cholesterol and LDL-cholesterol, which is associated with an increased risk of CVD [112].

HIV-related chronic inflammation is thought to predispose to development of DM. Brown et al. observed a decline in most inflammatory markers after ARV initiation; however, markers of TNF-α activation remained associated with DM, suggesting that residual inflammation despite suppressive antiretroviral therapy could play a role [113]. Lower values of nadir CD4 T-cell count and longer duration of HIV infection have been reported to be associated with development of DM [85].

Clinical implications

Physicians should assess individuals for metabolic complications and CV risk at the routine clinic to reduce MS and the associated CVD risk among people aging with HIV, since many of components of MS are under-diagnosed and under-treated conditions.

Although the presence of MS is associated with an increased risk of CVD, important established CVD RF such as age, smoking, total cholesterol and physical inactivity are not included in the MS definition [24]. Thus, risk assessment for the individuals’ absolute CVD risk is recommended and can be performed using a conventional risk prediction models such as Framingham, SCORE or other national prediction models, or by using newer models tailored to HIV-infected persons [114]. The estimated absolute CVD risk can guide the need for interventions.

Current HIV recommendations encourage the use of standard lifestyle interventions to prevent CVD including weight reduction, exercise, smoking cessation and eventually pharmacological interventions with anti-hypertensive and lipid-lowering therapy, and treatment of glucose metabolism alterations. In addition, other specific HIV-related recommendations have to be implemented in this population. Recent results of the START study proved the benefits of early ARV-initiation with reduced risk of AIDS and non-AIDS events [115]. In patients with high risk of CVD and diabetes, choice of ARV drugs with a more neutral metabolic and lipid profile as well as minimal drug-drug interactions with co-medications should be considered.

The ACC/AHA guidelines for the management of dyslipidaemia were recently updated, adapting lower thresholds for recommending statins, compared to the European guidelines [116,117].

Regarding glucose metabolism abnormalities, if glucose control is not achieved by lifestyle interventions alone, pharmacological therapy should be initiated, with metformin as the first choice of therapy. However, the current ADA and European Association for the Study of Diabetes guidelines emphasize a patient-centred approach, individualizing the choice of therapy with regards to patient preference, tolerability and drug-drug interactions [118].

Regarding clinical management of HTA, age, ethnicity and the presence of comorbidities such as renal impairment, diabetes, heart failure and ischemic heart disease together with potential drug-drug interactions should guide the selection of the antihypertensive therapy [119].

Conclusions and future directions

Multiple studies have demonstrated an increased risk of CVD in patients living with HIV. Numerous factors are thought to explain this excess in risk such as ARV and its metabolic toxicities, chronic inflammation and immune activation associated with HIV infection and an overrepresentation of traditional RFs.

MS is a multifactorial and heterogeneous disorder constituting a cluster of modifiable RF for CVD, which varies in prevalence and features within and across populations. The clinical validity of MS in detecting individuals at high-risk of CVD is still controversial, based on the heterogeneity of the syndrome; however it encompasses several important CVD risk factors. Among these, the prevalence of HTA is notably high in HIV-related MS.

A number of novel strategies are currently being investigated as adjuvant therapy in HIV infected persons in order to further reduce inflammation (statins, hydroxychloroquine, leflunomide), and platelet activation (aspirin, clopidogrel), to alter gut microbiota (probiotics) and to treat other persistent viral co-infections like CMV or HSV [120].

While eagerly expecting the results of these studies, and their potential benefit in clinical use, there is still room to improve the appliance of conventional preventive measures. Smoking cessation and targeted interventions with anti-hypertensives and lipid-lowering therapy have reduced CVD rates, in the settings where these have been rigorously implemented (ref: Petoumenos, HIV Med. 2011 Aug;12(7):412-21., Klein, Clin Infect Dis. 2015 Apr 15;60(8):1278-80.).

However, the prevalence of HTA, metabolic disturbances and MS will continue to increase, as the HIV population grows older. It is important that physicians remain vigilant and identify individuals at high-risk of CVD in order to implement preventive and therapeutic interventions to halt disease progression.

Footnotes

Statements

The manuscript does not contain clinical studies or patient data.

Conflict of interest

The authors declare that they have no conflict of interest.

References

1. FORD ES. Prevalence of the metabolic syndrome defined by the International Diabetes Federation among adults in the U.S. Diabetes Care. 2005;28:2745–9. [PubMed]
2. Grundy SM. Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation. 2005;112:2735–52. [PubMed]
3. Alberti KGMM, Zimmet P, Shaw J, IDF Epidemiology Task Force Consensus Group The metabolic syndrome–a new worldwide definition. Lancet. 2005;366:1059–62. [PubMed]
4. Alberti KGMM, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al. Harmonizing the Metabolic Syndrome: A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120:1640–5. [PubMed]
5. FORD ES, Cunningham TJ, Mercado CI. Lung function and metabolic syndrome: Findings of National Health and Nutrition Examination Survey 2007–2010. Journal of Diabetes. 2014;6:603–13. [PMC free article] [PubMed]
6. Miccoli R, Bianchi C, Odoguardi L, Penno G, Caricato F, Giovannitti MG, et al. Prevalence of the metabolic syndrome among Italian adults according to ATP III definition. Nutrition, Metabolism and Cardiovascular Diseases. 2005;15:250–4. [PubMed]
7. Maumus S, Marie B, Siest G, Visvikis-Siest S. A prospective study on the prevalence of metabolic syndrome among healthy french families: two cardiovascular risk factors (HDL cholesterol and tumor necrosis factor-alpha) are revealed in the offspring of parents with metabolic syndrome. Diabetes Care. 2005;28:675–82. [PubMed]
8. Wannamethee SG. The metabolic syndrome and cardiovascular risk in the British Regional Heart Study. Int J Obes Relat Metab Disord. 2008;32:S25–9. [PubMed]
9. Cicero AFG, Nascetti S, Noera G, Gaddi AV. Metabolic syndrome prevalence in Italy. Nutrition, Metabolism and Cardiovascular Diseases. 2006;16:e5–e6. [PubMed]
10. Bruno R, Gazzaruso C, Sacchi P, Zocchetti C, Giordanetti S, Garzaniti A, et al. High prevalence of metabolic syndrome among HIV-infected patients: link with the cardiovascular risk. JAIDS Journal of Acquired Immune Deficiency Syndromes. 2002;31:363–5. [PubMed]
11. Gazzaruso C, Sacchi P, Garzaniti A, Fratino P, Bruno R, Filice G. Prevalence of metabolic syndrome among HIV patients. Diabetes Care. 2002;25:1253–4. [PubMed]
12. Bernal E, Masia M, Padilla S, Martín-Hidalgo A, Gutiérrez F. Prevalence and characteristics of metabolic syndrome among HIV-infected patients from a Mediterranean cohort. Medicina clínica. 2007;128:172–5. –quiz1pfollowing200. [PubMed]
13. Magny Bergersen B, Schumacher A, Sandvik L, Bruun J, Birkeland K. Important differences in components of the metabolic syndrome between HIV-patients with and without highly active antiretroviral therapy and healthy controls. Scand J Infect Dis. 2006;38:682–9. [PubMed]
14. Jacobson DL, Tang AM, Spiegelman D, Thomas AM, Skinner S, Gorbach SL, et al. Incidence of metabolic syndrome in a cohort of HIV-infected adults and prevalence relative to the US population (National Health and Nutrition Examination Survey) JAIDS Journal of Acquired Immune Deficiency Syndromes. 2006;43:458–66. [PubMed]
15. Wand H, Calmy A, Carey DL, Samaras K, Carr A, Law MG, et al. Metabolic syndrome, cardiovascular disease and type 2 diabetes mellitus after initiation of antiretroviral therapy in HIV infection. AIDS. 2007;21:2445–53. [PubMed]
16. Palacios R, Santos J, González M, Ruiz J, M M. Incidence and prevalence of the metabolic syndrome in a cohort of naive HIV-infected patients: prospective analysis at 48 weeks of highly active antiretroviral therapy. 2007:1–4. [PubMed]
17. Martin L de S, Pasquier E, Roudaut N, Vandhuick O, Vallet S, Bellein V. et al. Metabolic syndrome: A major risk factor for atherosclerosis in HIV-infected patients (SHIVA study) La Presse Médicale. 2008;37:579–84. [PubMed]
18. Samaras K, Wand H, Law M, Emery S, Cooper D, Carr A. Prevalence of Metabolic Syndrome in HIV-Infected Patients Receiving Highly Active Antiretroviral Therapy Using International Diabetes Foundation and Adult Treatment Panel III Criteria: Associations with insulin resistance, disturbed body fat compartmentalization, elevated C-reactive protein, and hypoadiponectinemia. Diabetes Care. 2006;30:113–9. [PubMed]
19. Jericó C, Knobel H, Montero M, Ordoñez-Llanos J, Guelar A, Gimeno JL, et al. Metabolic syndrome among HIV-infected patients: prevalence, characteristics, and related factors. Diabetes Care. 2005;28:132–7. [PubMed]
20. Sobieszczyk ME, Hoover DR, Anastos K, Mulligan K, Tan T, Shi Q, et al. Prevalence and predictors of metabolic syndrome among HIV-infected and HIV-uninfected women in the Women’s Interagency HIV Study. JAIDS Journal of Acquired Immune Deficiency Syndromes. 2008;48:272–80. [PubMed]
21. Hansen BR, Petersen J, Haugaard SB, Madsbad S, Obel N, Suzuki Y, et al. The prevalence of metabolic syndrome in Danish patients with HIV infection: the effect of antiretroviral therapy. HIV Med. 2009;10:378–87. [PubMed]
22. Estrada V, Martínez-Larrad MT, González-Sánchez JL, de Villar NGP, Zabena C, Fernández C, et al. Lipodystrophy and metabolic syndrome in HIV-infected patients treated with antiretroviral therapy. Metabolism. 2006;55:940–5. [PubMed]
23•. Worm SW, Sabin CA, Reiss P, El-Sadr W, d’Arminio Monforte A, Pradier C, et al. Presence of the Metabolic Syndrome Is Not a Better Predictor of Cardiovascular Disease Than the Sum of Its Components in HIV-Infected Individuals: Data Collection on Adverse events of Anti-HIV Drugs (D:A:D) study. Diabetes Care. 2009;32:474–80. In the D:A:D study, the effect of the different components of the metabolic syndrome (MS) on the risk of cardiovascular disease (CVD) was examined. A strong correlation between increasing number of components of the MS and CVD risk was found. However, the correlation between CVD and MS disappeared after adjusting for the individual components of MS. [PMC free article] [PubMed]
24•. Worm SW, Friis-Møller N, Bruyand M, Monforte AD, Rickenbach M, Reiss P, et al. High prevalence of the metabolic syndrome in HIV-infected patients: impact of different definitions of the metabolic syndrome. AIDS. 2010;24:427–35. The D:A:D study examined the prevalence of the metabolic syndrome (MS) at the end of six calendar periods from 2000 to 2007 using different definitions of the metabolic syndrome. An increasing prevalence of MS was reported. However, very different results were reported depending of the applied MS definition, highlighting the challenges faced in the observational studies with potential bias, missing data and measurement variability. [PubMed]
25. Mondy K, Overton ET, Grubb J, Tong S, Seyfried W, Powderly W, et al. Metabolic Syndrome in HIV-Infected Patients from an Urban, Midwestern US Outpatient Population. Clin Infect Dis. 2007;44:726–34. [PMC free article] [PubMed]
26. Adeyemi O, Rezai K, Bahk M, Badri S, Thomas-Gossain N. Metabolic Syndrome in Older HIV-Infected Patients: Data from the CORE50 Cohort. AIDS Patient Care STDS. 2008;22:941–5. [PubMed]
27. Bonfanti P, Giannattasio C, Ricci E, Facchetti R, Rosella E, Franzetti M, et al. HIV and metabolic syndrome: a comparison with the general population. JAIDS Journal of Acquired Immune Deficiency Syndromes. 2007;45:426–31. [PubMed]
28. Bonfanti P, De Socio GLV, Marconi P, Franzetti M, Martinelli C, Vichi F, et al. Is metabolic syndrome associated to HIV infection per se? Results from the HERMES study. Curr HIV Res. 2010;8:165–71. [PubMed]
29. Elgalib A, Aboud M, Kulasegaram R, Dimian C, Duncan A, Wierzbicki AS, et al. The assessment of metabolic syndrome in UK patients with HIV using two different definitions: CREATE 2 study. Current Medical Research and Opinion. 2010;27:63–9. [PubMed]
30. Mangili A, Jacobson DL, Gerrior J, Polak JF, Gorbach SL, Wanke CA. Metabolic Syndrome and Subclinical Atherosclerosis in Patients Infected with HIV. Clin Infect Dis. 2007;44:1368–74. [PMC free article] [PubMed]
31. Falasca K, Ucciferri C, Manzoli L, Mancino P, Pizzigallo E, Conti P, et al. Metabolic syndrome and cardiovascular risk in HIV-infected patients with lipodystrophy. Int J Immunopathol Pharmacol. 2007;20:519–27. [PubMed]
32. Baum MK, Rafie C, Lai S, Xue L, Sales S, Page JB, et al. Coronary Heart Disease (CHD) Risk Factors and Metabolic Syndrome in HIV-Positive Drug Users in Miami. Am J Infect Dis. 2006;2:173–9. [PMC free article] [PubMed]
33. Young J, Glass TR, Bernasconi E, Rickenbach M, Furrer H, Hirschel B, et al. Hierarchical modeling gave plausible estimates of associations between metabolic syndrome and components of antiretroviral therapy. Journal of Clinical Epidemiology. Elsevier Inc. 2009;62:632–41. [PubMed]
34. Biron A, Bobin-Dubigeon C, Volteau C, Piroth L, Perré P, Leport C, et al. Metabolic Syndrome in French HIV-Infected Patients: Prevalence and Predictive Factors After 3 Years of Antiretroviral Therapy. AIDS Research and Human Retroviruses. 2012;28:1672–8. [PubMed]
35. Bonfanti P, De Socio GV, Ricci E, Antinori A, Martinelli C, Vichi F, et al. The feature of Metabolic Syndrome in HIV naive patients is not the same of those treated: results from a prospective study. Biomedicine et Pharmacotherapy [Internet]. Elsevier Masson SAS. 2012;66:348–53. Available from: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=22705335&retmode=ref&cmd=prlinks. [PubMed]
36. Alvarez C, Salazar R, Galindez J, Rangel F, Castañeda ML, Lopardo G, et al. Metabolic syndrome in HIV-infected patients receiving antiretroviral therapy in Latin America. Brazilian Journal of Infectious Diseases Elsevier. 2010;14:256–63. [PubMed]
37. Signorini DJHP, Monteiro MCM, de Fátima Castro de Andrade M, Signorini DH, de Araújo Eyer-Silva W. What should we know about metabolic syndrome and lipodystrophy in AIDS? Rev Assoc Med Bras Elsevier. 2012;58:70–5.
38•. Krishnan S, Schouten JT, Atkinson B, Brown T, Wohl D, McComsey GA, et al. Metabolic syndrome before and after initiation of antiretroviral therapy in treatment-naive HIV-infected individuals. J Acquir Immune Defic Syndr. 2012;61:381–9. This study examined the prevalence, incidence and risk factors for metabolic syndrome (MS) in the ART-naïve HIV-infected individuals from the Clinical Trial Group Longitudinal Linket Randomized Trials (ALLRT) cohort with 2554 individuals. At baseline the prevalence of MS was 20%. The median follow-up time was 2.8 years and the incidence rate of MS during the study was 8.5 per 100 person-years. Low CD4+ T-cell counts, lack of virologic suppression and use of PI-based regimen were associated with risk of MS. [PMC free article] [PubMed]
39. Alencastro PR, Fuchs SC, Wolff FH, Ikeda ML, Brandão ABM, Barcellos NT. Independent Predictors of Metabolic Syndrome in HIV-Infected Patients. AIDS Patient Care STDS. 2011;25:627–34. [PubMed]
40. Alencastro PR, Wolff FH, Oliveira RR, Ikeda M. Metabolic syndrome and population attributable risk among HIV/AIDS patients: comparison between NCEP-ATPIII, IDF and AHA/NHLBI definitions. AIDS Research and Therapy. 2012:1–7. [PMC free article] [PubMed]
41. Calza L, Masetti G, Piergentili B, Trapani F, Cascavilla A, Manfredi R, et al. Prevalence of diabetes mellitus, hyperinsulinaemia and metabolic syndrome among 755 adult patients with HIV-1 infection. International journal of STD & AIDS. 2011;22:43–5. [PubMed]
42. Wu PY, Hung CC, Liu WC, Hsieh CY, Sun HY, Lu CL, et al. Metabolic syndrome among HIV-infected Taiwanese patients in the era of highly active antiretroviral therapy: prevalence and associated factors. Journal of Antimicrobial Chemotherapy. 2012;67:1001–9. [PubMed]
43. Freitas P, Carvalho D, Souto S, Santos AC, Xerinda S, Marques R, et al. Impact of Lipodystrophy on the prevalence andcomponents of metabolic syndrome in HIV-infected patients. BMC Infect Dis BioMed Central Ltd. 2011;11:246. [PMC free article] [PubMed]
44. Maloberti A, Giannattasio C, Dozio D, Betelli M, Villa P, Nava S, et al. Metabolic Syndrome in Human Immunodeficiency Virus–Positive Subjects: Prevalence, Phenotype, and Related Alterations in Arterial Structure and Function. Metabolic Syndrome and Related Disorders. 2013;11:403–11. [PubMed]
45. Cubero JM, Domingo P, Sambeat M, Ordoñez-Llanos J, Rodriguez-Espinosa J, Sánchez-Quesada JL, et al. Prevalence of Metabolic Syndrome Among Human Immunodeficiency Virus–Infected Subjects Is Widely Influenced by the Diagnostic Criteria. Metabolic Syndrome and Related Disorders. 2011;9:345–51. [PubMed]
46. Sawadogo A, Sanou S, Hema A, Kamboule BE, Kabore NF, Sore I, et al. Metabolic syndrome and cardiovascular risk patients under antiretrovirals in a hospital day at Bobo-Dioulasso (Burkina Faso) Bull Soc Pathol Exot. 2014;107:151–8. [PubMed]
47. Jantarapakde J, Phanuphak N, Chaturawit C, Pengnonyang S, Mathajittiphan P, Takamtha P, et al. Prevalence of Metabolic Syndrome Among Antiretroviral-Naive and Antiretroviral-Experienced HIV-1 Infected Thai Adults. AIDS Patient Care STDS. 2014;28:331–40. [PubMed]
48. Guira O, Tieno H, Diendere AE, Sagna Y, Diallo I, Yameogo B, et al. Features of Metabolic Syndrome and Its Associated Factors during Highly Active Antiretroviral Therapy in Ouagadougou (Burkina Faso) Journal of the International Association of Providers of AIDS Care (JIAPAC) 2015 [PubMed]
49. Oguoma VM, Nwose EU, Richards RS. Prevalence of cardio-metabolic syndrome in Nigeria: a systematic review. Public Health Elsevier Ltd. 2015;129:413–23. [PubMed]
50. Tesfaye DY, Kinde S, Medhin G, Megerssa YC, Tadewos A, Tadesse E, et al. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. Diabetes & Metabolic Syndrome: Clinical Research & Reviews Diabetes India. 2014;8:102–7.
51. Tiozzo E. A cross-sectional assessment of metabolic syndrome in HIV-infected people of low socio- economic status receiving antiretroviral therapy. 2015:1–8. [PMC free article] [PubMed]
52. Lombo B, Alkhalil I, Golden MP, Fotjadhi I, Ravi S, Virata M, et al. Prevalence of Metabolic Syndrome in Patients with HIV in the Era of Highly Active Antiretroviral Therapy. Conn Med. 2015;79:277–81. [PubMed]
53. Worm SW, De Wit S, Weber R, Sabin CA, Reiss P, El-Sadr W, et al. Diabetes Mellitus, Preexisting Coronary Heart Disease, and the Risk of Subsequent Coronary Heart Disease Events in Patients Infected With Human Immunodeficiency Virus: The Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D Study) Circulation. 2009;119:805–11. [PMC free article] [PubMed]
54. Jerico C, Knobel H, Montero M, Sorli M, Guelar A, Gimeno J, et al. Hypertension in HIV-Infected Patients: Prevalence and Related Factors. American Journal of Hypertension. 2005;18:1396–401. [PubMed]
55. FORD ES, LI C, ZHAO G. Prevalence and correlates of metabolic syndrome based on a harmonious definition among adults in the US*. Journal of Diabetes. 2010;2:180–93. [PubMed]
56. FORD ES, Kohl HW, Mokdad AH, Ajani UA. Sedentary behavior, physical activity, and the metabolic syndrome among U.S. adults. Obes Res. 2005;13:608–14. [PubMed]
57. Jaggers JR, Prasad VK, Dudgeon WD, Blair SN, Sui X, Burgess S, et al. Associations between physical activity and sedentary time on components of metabolic syndrome among adults with HIV. AIDS Care. 2014;26:1387–92. [PMC free article] [PubMed]
58•. Krishnan S, Schouten JT, Atkinson B, Brown TT, Wohl DA, McComsey GA, et al. Changes in metabolic syndrome status after initiation of antiretroviral therapy. J Acquir Immune Defic Syndr. 2015;68:73–80. This study assessed the metabolic syndrome (MS) in the ART-naïve HIV-infected individuals from the Clinical Trial Group Longitudinal Linket Randomized Trials (ALLRT) cohort with 2554 individuals at ARV initiation and every 48 weeks. At baseline 20% of ALLRT individuals had MS. At 96 weeks 37% of individuals with MS at baseline did no longer met the MS cristeria. [PMC free article] [PubMed]
59. de Waal R, Cohen K, Maartens G. Systematic Review of Antiretroviral-Associated Lipodystrophy: Lipoatrophy, but Not Central Fat Gain, Is an Antiretroviral Adverse Drug Reaction. In: Darlix J-LEPH, editor. PLoS ONE. Vol. 8. 2013. p. e63623. [PMC free article] [PubMed]
60. Capeau J. From lipodystrophy and insulin resistance to metabolic syndrome: HIV infection, treatment and aging. Current Opinion in HIV and AIDS. 2007;2:247–52. ed 2. [PubMed]
61. Palios J, Kadoglou NPE, Lampropoulos S. The Pathophysiology of HIV-/HAART-Related Metabolic Syndrome Leading to Cardiovascular Disorders: The Emerging Role of Adipokines. Experimental Diabetes Research. 2012;2012:101–13. [PMC free article] [PubMed]
62. Villarroya F, Domingo P, Giralt M. Biochimica et Biophysica Acta BBA – Molecular and Cell Biology of Lipids. Elsevier B.V. 2010;1801:392–9. [PubMed]
63. Tsiodras S, Perelas A, Wanke C, Mantzoros CS. The HIV-1/HAART associated metabolic syndrome e Novel adipokines, molecular associations and therapeutic implications. J Infect Elsevier Ltd. 2010;61:101–13. [PubMed]
64. Seaberg EC, Muñoz A, Lu M, Detels R, Margolick JB, Riddler SA, et al. Association between highly active antiretroviral therapy and hypertension in a large cohort of men followed from 1984 to 2003. AIDS. 2005;19:953–60. [PubMed]
65•. Nüesch R, Wang Q, Elzi L, Bernasconi E, Weber R, Cavassini M, et al. Risk of cardiovascular events and blood pressure control in hypertensive HIV-infected patients: Swiss HIV Cohort Study (SHCS) J Acquir Immune Defic Syndr. 2013;62:396–404. Risk for cardiovascular disease was assessed in patients from the Swiss HIV Cohort Study with hypertension followed between April 1, 2000 and March 31, 2011. Hypertension was diagnosed in 2595 of 10,361 eligible patients and, of those, 869 initiated antihypertensive treatment. Lack of hypertension control was associated with an increased risk of CVD. [PubMed]
66. Baekken M, Os I, Sandvik L, Oektedalen O. Hypertension in an urban HIV-positive population compared with the general population: influence of combination antiretroviral therapy. Journal of Hypertension. 2008;26:2126–33. [PubMed]
67. Thiébaut R, El-Sadr WM, Friis-Møller N, Rickenbach M, Reiss P, Monforte AD, et al. Predictors of hypertension and changes of blood pressure in HIV-infected patients. Antivir Ther. 2005;10:811–23. [PubMed]
68. Schouten J, Wit FW, Stolte IG, Kootstra NA, van der Valk M, Geerlings SE, et al. Cross-sectional Comparison of the Prevalence of Age-Associated Comorbidities and Their Risk Factors Between HIV-Infected and Uninfected Individuals: The AGEhIV Cohort Study. Clin Infect Dis. 2014;59:1787–97. [PubMed]
69. Gazzaruso C, Bruno R, Garzaniti A, Giordanetti S, Fratino P, Sacchi P, et al. Hypertension among HIV patients: prevalence and relationships to insulin resistance and metabolic syndrome. Journal of Hypertension. 2003;21:1377–82. [PubMed]
70. Peck RN, Shedafa R, Kalluvya S, Downs JA, Todd J, Suthanthiran M, et al. Hypertension, kidney disease, HIV andantiretroviral therapy among Tanzanian adults:a cross-sectional study. 2014:1–11. [PMC free article] [PubMed]
71. Bergersen BM, Sandvik L, Dunlop O, Birkeland K, Bruun JN. Prevalence of Hypertension in HIV-Positive Patients on Highly Active Retroviral Therapy (HAART) Compared with HAART-Naïve and HIV-Negative Controls: Results from a Norwegian Study of 721 Patients. Eur J Clin Microbiol Infect Dis. 2003;22:731–6. [PubMed]
72. Khalsa A, Karim R, Mack WJ, Minkoff H, Cohen M, Young M, et al. Correlates of prevalent hypertension in a large cohort of HIV-infected women: Women’s Interagency HIV Study. AIDS. 2007;21:2539–41. [PubMed]
73. Chu C, Umanski G, Blank A, Meissner P, Grossberg R, Selwyn PA. Comorbidity-Related Treatment Outcomes among HIV-Infected Adults in the Bronx, NY. J Urban Health. 2011;88:507–16. [PMC free article] [PubMed]
74. De Socio GV, Ricci E, Maggi P, Parruti G, Pucci G, Di Biagio A, et al. Prevalence, Awareness, Treatment, and Control Rate of Hypertension in HIV-Infected Patients: The HIV-HY Study. American Journal of Hypertension. 2013;27:222–8. [PubMed]
75. Bernardino JI, Mora M, Zamora FX, Arribas B, Montes ML, Pascual-Pareja F, et al. Hypertension and isolated office hypertension in HIV-infected patients determined by ambulatory blood pressure monitoring: prevalence and risk factors. J Acquir Immune Defic Syndr. 2011;58:54–9. [PubMed]
76. Krauskopf K, Natta MLV, Danis RP, Gangaputra S, Ackatz L, Addessi A, et al. Correlates of Hypertension in Patients with AIDS in the Era of Highly Active Antiretroviral Therapy. Journal of the International Association of Providers of AIDS Care (JIAPAC) 2013;12:325–33. [PMC free article] [PubMed]
77. Friis-Møller N, Weber R, Reiss P, Thiébaut R, Kirk O, d’Arminio Monforte A, et al. Cardiovascular disease risk factors in HIV patients–association with antiretroviral therapy. Results from the DAD study. AIDS. 2003;17:1179–93. [PubMed]
78. Freitas P, Carvalho D, Santos AC, Madureira AJ, Xerinda S, Martinez E, et al. Central/Peripheral Fat Mass Ratio Is Associated With Increased Risk of Hypertension in HIV-Infected Patients. The Journal of Clinical Hypertension. 2012;14:593–600. [PubMed]
79. Sattler FR, Qian D, Louie S, Johnson D, Briggs W, DeQuattro V, et al. Elevated blood pressure in subjects with lipodystrophy. AIDS. 2001;15:2001–10. [PubMed]
80. Okello S, Kanyesigye M, Muyindike WR, Annex BH, Hunt PW, Haneuse S, et al. Incidence and predictors of hypertension in adults with HIV-initiating antiretroviral therapy in south-western Uganda. Journal of Hypertension. 2015;33:2039–45. [PMC free article] [PubMed]
81. Nduka CU, Stranges S, Sarki AM, Kimani PK, Uthman OA. Evidence of increased blood pressure and hypertension riskamong people living with HIV on antiretroviral therapy:a systematic review with meta-analysis. Nature Publishing Group; 2015. pp. 1–8. [PubMed]
82. Savès M, Chene G, Ducimetière P, Leport C, Le Moal G, Amouyel P, et al. Risk factors for coronary heart disease in patients treated for human immunodeficiency virus infection compared with the general population. Clin Infect Dis. 2003;37:292–8. [PubMed]
83. D’Ascenzo F, Quadri G, Cerrato E, Calcagno A, Omedè P, Grosso Marra W, et al. A meta-analysis investigating incidence and features of stroke in HIV-infected patients in the highly active antiretroviral therapy era. Journal of Cardiovascular Medicine. 2015;16:839–43. [PubMed]
84•. Armah KA, Chang CCH, Baker JV, Ramachandran VS, Budoff MJ, Crane HM, et al. Prehypertension, Hypertension, and the Risk of Acute Myocardial Infarction in HIV-Infected and -Uninfected Veterans. Clin Infect Dis. 2013;58:121–9. In the Veterans Aging Cohort Study Virtual Cohort (VACS VC) study they examine whether HIV-infected people with hypertension had higher risk of AMI compared to uninfected individuals. The median follow-up was 5.9 years and 860 incident AMIs were registered. Low and high prehypertension and hypertension regardless of antihypertensive treatment in HIV-infected individuals was associated with an increased risk of AMI compared to uninfected, untreated normotensive individuals. [PMC free article] [PubMed]
85. Galli L, Salpietro S, Pellicciotta G, Galliani A, Piatti P, Hasson H, et al. Risk of type 2 diabetes among HIV-infected and healthy subjects in Italy. Eur J Epidemiol. 2012;27:657–65. [PubMed]
86. Brown TT, Cole SR, Li X, Kingsley LA, Palella FJ, Riddler SA, et al. Antiretroviral therapy and the prevalence and incidence of diabetes mellitus in the multicenter AIDS cohort study. Arch Intern Med. 2005;165:1179–84. [PubMed]
87. Maganga E, Smart LR, Kalluvya S, Kataraihya JB, Saleh AM, Obeid L, et al. Glucose Metabolism Disorders, HIV and Antiretroviral Therapy among Tanzanian Adults. In: Pacheco AG, editor. PLoS ONE. Vol. 10. 2015. p. e0134410. [PMC free article] [PubMed]
88. Tripathi A, Liese AD, Jerrell JM, Zhang J, Rizvi AA, Albrecht H, et al. Incidence of diabetes mellitus in a population-based cohort of HIV-infected and non-HIV-infected persons: the impact of clinical and therapeutic factors over time. Diabet Med. 2014;31:1185–93. [PubMed]
89. Rasmussen LD, Mathiesen ER, Kronborg G, Pedersen C, Gerstoft J, Obel N. Risk of Diabetes Mellitus in Persons with and without HIV: A Danish Nationwide Population-Based Cohort Study. In: Atashili J, editor. PLoS ONE. Vol. 7. 2012. p. e44575. [PMC free article] [PubMed]
90. Butt AA, McGinnis K, Rodriguez-Barradas MC, Crystal S, Simberkoff M, Goetz MB, et al. HIV infection and the risk of diabetes mellitus. AIDS. 2009;23:1227–34. [PMC free article] [PubMed]
91. Ledergerber B, Furrer H, Rickenbach M, Lehmann R, Elzi L, Hirschel B, et al. Factors Associated with the Incidence of Type 2 Diabetes Mellitus in HIV-Infected Participants in the Swiss HIV Cohort Study. Clin Infect Dis. 2007;45:111–9. [PubMed]
92. De Wit S, Sabin CA, Weber R, Worm SW, Reiss P, Cazanave C, et al. Incidence and risk factors for new-onset diabetes in HIV-infected patients: the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study. Diabetes Care. 2008;31:1224–9. [PMC free article] [PubMed]
93. Grundy SM. Metabolic syndrome update Trends in Cardiovascular Medicine. Elsevier; 2015. pp. 1–10.
94. Fitch KV, Lo J, Abbara S, Ghoshhajra B, Shturman L, Soni A, et al. Increased coronary artery calcium score and noncalcified plaque among HIV-infected men: relationship to metabolic syndrome and cardiac risk parameters. J Acquir Immune Defic Syndr. 2010;55:495–9. [PMC free article] [PubMed]
95•. Fitch K, Abbara S, Lee H, Stavrou E, Sacks R, Michel T, et al. Effects of lifestyle modification and metformin on atherosclerotic indices among HIV-infected patients with the metabolic syndrome. AIDS. 2012;26:587–97. In this randomized, placebo-controlled trial the effect of lifestyle modification and metformin was examined over 1 year, among 50 HIV-infected patients with metabolic syndrome (MS). Metformin was found to reduce CAC and calcified plaque volume in HIV-infected patients with MS. Lifestyle modification had an effect to improve HDL-cholesterol and hsCRP, but had a lesser effect to prevent plaque progression. [PMC free article] [PubMed]
96•. Jarrett OD, Wanke CA, Ruthazer R, Bica I, Isaac R, Knox TA. Metabolic Syndrome Predicts All-Cause Mortality in Persons with Human Immunodeficiency Virus. AIDS Patient Care STDS. 2013;27:266–71. In this study data from 567 HIV-infected individuals from the Nutrition for Healthy Living study from 2000 to 2005 were examined. Metabolic syndrome and high triglycerides were independently associated with and increased risk of all-cause mortality after 36 months of follow-up. [PMC free article] [PubMed]
97. Strategies for Management of Antiretroviral Therapy (SMART) Study Group. El-Sadr WM, Lundgren JD, Neaton JD, Gordin F, Abrams D, et al. CD4+ count-guided interruption of antiretroviral treatment. N Engl J Med. 2006;355:2283–96. [PubMed]
98. SMART Study Group. El-Sadr WM, Grund B, Neuhaus J, Babiker A, Cohen CJ, et al. Risk for opportunistic disease and death after reinitiating continuous antiretroviral therapy in patients with HIV previously receiving episodic therapy: a randomized trial. Ann Intern Med. 2008;149:289–99. [PubMed]
99. JevtoviC D, DragoviC G, SalemoviC D, Ranin J, DjurkoviC-DjakoviC O. The metabolic syndrome, an epidemic among HIV-infected patients on HAART. Biomedicine et Pharmacotherapy. Elsevier Masson SAS. 2009;63:337–42. [PubMed]
100. Noor MA, Lo JC, Mulligan K, Schwarz JM, Halvorsen RA, Schambelan M, et al. Metabolic effects of indinavir in healthy HIV-seronegative men. AIDS. 2001;15:F11–8. [PMC free article] [PubMed]
101. Lee GA, Seneviratne T, Noor MA, Lo JC, Schwarz J-M, Aweeka FT, et al. The metabolic effects of lopinavir/ritonavir in HIV-negative men. AIDS. 2004;18:641–9. [PMC free article] [PubMed]
102. Monforte AD, Reiss P, Ryom L, El-Sadr W, Dabis F, De Wit S, et al. Atazanavir is not associated with an increased risk of cardio or cerebrovascular disease events. AIDS. 2013;27:407–15. [PubMed]
103. Martin-Iguacel R, Llibre JM, Friis-Møller N. Risk of Cardiovascular Disease in an Aging HIV Population: Where Are We Now? Curr HIV/AIDS Rep. 2015 [PubMed]
104. Phillips AN, Carr A, Neuhaus J, Visnegarwala F, Prineas R, Burman WJ, et al. Interruption of antiretroviral therapy and risk of cardiovascular disease in persons with HIV-1 infection: exploratory analyses from the SMART trial. Antivir Ther. 2008;13:177–87. [PubMed]
105. Franssen R, Sankatsing RR, Hassink E, Hutten B, Ackermans MT, Brinkman K, et al. Nevirapine Increases High-Density Lipoprotein Cholesterol Concentration by Stimulation of Apolipoprotein A-I Production. Arteriosclerosis, Thrombosis, and Vascular Biology. 2009;29:1336–41. [PubMed]
106. Deeks SG, Tracy R, Douek DC. Perspective. Immunity. Elsevier Inc. 2013;39:633–45. [PMC free article] [PubMed]
107. Stankov MV, Behrens GMN. Contribution of inflammation to fat redistribution and metabolic disturbances in HIV-1 infected patients. Curr Pharm Des. 2010;16:3361–71. [PubMed]
108. Duprez DA, Neuhaus J, Kuller LH, Tracy R, Belloso W, De Wit S, et al. Inflammation, Coagulation and Cardiovascular Disease in HIV-Infected Individuals. In: Thorne C, editor. PLoS ONE. Vol. 7. 2012. p. e44454. [PMC free article] [PubMed]
109. El-Sadr WM, Mullin CM, Carr A, Gibert C, Rappoport C, Visnegarwala F, et al. Effects of HIV disease on lipid, glucose and insulin levels: results from a large antiretroviral-naive cohort. HIV Med. 2005;6:114–21. [PubMed]
110. Riddler SA, Smit E, Cole SR, Li R, Chmiel JS, Dobs A, et al. Impact of HIV infection and HAART on serum lipids in men. JAMA. 2003;289:2978–82. [PubMed]
111. Das S, Shahmanesh M, Stolinski M, Shojaee-Moradie F, Jefferson W, Jackson NC, et al. In treatment-naïve and antiretroviral-treated subjects with HIV, reduced plasma adiponectin is associated with a reduced fractional clearance rate of VLDL, IDL and LDL apolipoprotein B-100. Diabetologia. 2006;49:538–42. [PubMed]
112. Rose H, Low H, Dewar E, Bukrinsky M, Hoy J, Dart A, et al. Atherosclerosis. Atherosclerosis. Elsevier Ltd. 2013;229:206–11. [PMC free article] [PubMed]
113. Brown TT, Tassiopoulos K, Bosch RJ, Shikuma C, McComsey GA. Association Between Systemic Inflammation and Incident Diabetes in HIV-Infected Patients After Initiation of Antiretroviral Therapy. Diabetes Care. 2010;33:2244–9. [PMC free article] [PubMed]
114. Friis-Møller N, Ryom L, Smith C, Weber R, Reiss P, Dabis F, et al. An updated prediction model of the global risk of cardiovascular disease in HIV-positive persons: The Data-collection on Adverse Effects of Anti-HIV Drugs (D:A:D) study. European Journal of Preventive Cardiology. 2015 [PubMed]
115. The INSIGHT START Study Group. Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection. N Engl J Med. 2015 150720091517005. [PMC free article] [PubMed]
116. Stone NJ, Robinson JG, Lichtenstein AH, Merz CNB, Blum CB, Eckel RH, et al. 2013 ACC/AHA Guideline on theTreatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults. J Am Coll Cardiol Elsevier. 2014;63:2889–934. [PubMed]
117. Ray KK, Kastelein JJP, Matthijs Boekholdt S, Nicholls SJ, Khaw KT, Ballantyne CM, et al. The ACC/AHA 2013 guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular disease risk in adults: the good the bad and the uncertain: a comparison with ESC/EAS guidelines for the management of dyslipidaemias 2011. Eur Heart J. 2014;35:960–8. [PubMed]
118. Monroe AK, Glesby MJ, Brown TT. Diagnosing and Managing Diabetes in HIV-Infected Patients: Current Concepts. Clin Infect Dis. 2015;60:453–62. [PubMed]
119. Ryom L, Boesecke C, Gisler V, Manzardo C, Rockstroh JK, Puoti M, et al. Essentials from the 2015 European AIDS Clinical Society (EACS) guidelines for the treatment of adult HIV-positive persons. HIV Med. 2015;17:83–8. [PubMed]
120. Hsu DC, Sereti I, Ananworanich J. Serious Non-AIDS events: Immunopathogenesis and interventional strategies. AIDS Res Ther. 2013;10:29. [PMC free article] [PubMed]