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Logo of mjafiGuide for AuthorsAbout this journalExplore this journalMedical Journal, Armed Forces India
 
Med J Armed Forces India. 1998 October; 54(4): 374.
Published online 2017 June 26. doi:  10.1016/S0377-1237(17)30618-4
PMCID: PMC5531744

ROLE OF AYURVEDIC DRUGS IN TREATMENT OF HIV INFECTION

Dear Editor,

It is estimated that over 23 million people world wide are having HIV infection and of which over 8.1 million people have developed AIDS [1]. The situation is going to be worse in coming years. India is having largest number of HIV infected cases in South Asia. Treatment of HIV infection/AIDS has been by and large symptomatic especially that of different opportunistic infections. More recently some antiretroviral agents consisting of combination of reverse transcriptase inhibitors and protease inhibitors have been found to be effective [2]. However the cost of this therapy is exorbitant and duration of treatment is uncertain. Hence search for cure of HIV infection in alternate medicine is being tried. There are few newspaper reports on effectiveness of some plants in China and India. Recently some clinical trials of ayurvedic drugs on animal models have been found to augment immunity [3]. An attempt has been made to see the effectiveness of some of Ayurvedic medicine in cases of HIV infection.

A total of 50 western blot confirmed asymptomatic HIV infection cases were taken for study at HIV surveillance centre Command Hospital (SC) Pune from Sep 95 to Dec 96. All patients were male and were divided in two equal groups of 25 cases each randomly. All patients underwent thorough general and systemic examination including weight record. All relevant routine investigation were also done to rule out associated disorders. One group of patients were given Ayurvedic drugs in consultation with physicians at Lokmanya Tilak Ayurvedic Medical College and Hospital, Pune. The ayurvedic drugs, Guduchi, Amalaki and Shatavari, considered to build general immunity, were given to all patients in this group. In addition blood letting of 60 to 100 ml on two occasions at interval of 15 days was done in these patients. Blood letting is supposed to eliminate offending wastage material in the vitiated blood. Other group of patients (Control) were given placebo. All patients were given one month supervised institutional treatment followed by two months self administered out patients treatment. At the end of three months all patients were reassessed clinically and by repeating relevant haematological parameters.

The result of this preliminary study showed statistically significant weight gain of around 5% in 9 (36%) cases of study group. Rest of the cases in both group had static weight at the end of three months. No significant difference was found in laboratory parameters (haemoglobin estimation, absolute lymphocyte count and platelet count) among both groups. More specific parameters/markers like P24 antigen, CD4 count and HIV RNA load would have been better prognostic markers but these could not be done due to non availability during period of study.

Although our study shows weight gain in statistically significant percent of cases of study group but this alone cannot be taken as parameter of augmented immunity. We are still continuing the study with large number of cases along with parameters like CD4 count and P24 antigen test. The result of which will be published subsequently and may be more conclusive.

REFERENCES

1. Narayan JP. HIV/AIDS and sexually transmitted diseases. An update. WHO Southeast Asia New Delhi. 1997;1
2. Chaudhary MN, Shepp DH. Antiretroviral agents current uses. Dermatologic clinic. 1997;15:319–329. [PubMed]
3. Thatte UM, Chabbria S, Karandikar SM, Dahnukar SA. Immunotherapeutic modification of E Coli induced abdominal sepsis and mortality in mice. Indian Medicinal Plants. 1993:128–130.

Articles from Medical Journal, Armed Forces India are provided here courtesy of Elsevier