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An overview of Personal Profiles can be found at http://www.moloncol.org.
Carlo M. Croce
The John W. Wolfe Chair in Human Cancer Genetics; Chairman, Department of Molecular Virology, Immunology and Medical Genetics; Director, Human Cancer Genetics Program; Director, Genetics Institute, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
An excellent researcher whose work has revealed the variety of mutated genes involved in leukemias, lymphomas and other cancers, Carlo M. Croce, M.D., Director of Human Cancer Genetics, Chairman of Molecular Virology, Immunology and Medical Genetics, and Director of the Institute of Genetics at The Ohio State University Comprehensive Cancer Center, has been awarded the 30th Annual Jeffrey A. Gottlieb Memorial Award. Dr. Croce is world‐renowned for his contributions involving the genes and genetic mechanisms implicated in the pathogenesis of human cancer. During the course of his career, he discovered the juxtaposition of the human immunoglobulin genes to the MYC oncogene, the deregulation of MYC in Burkitt lymphoma, the ALL1 gene involved in acute leukemias, the TCL1 gene associated with T‐cell leukemias, and cloned and characterized the BCL2 gene involved in follicular lymphoma. Dr. Croce has also uncovered the early events involved in the pathogenesis of lung, nasopharyngeal, head and neck, esophageal, gastrointestinal and breast cancers. His discoveries have led to revolutionary innovations in the development of novel and successful approaches to cancer prevention, diagnosis, monitoring and treatment, based on gene‐target discovery, verification and rational drug development. A native of Milan, Italy, Dr. Croce earned his medical degree, summa cum laude, in 1969 from the School of Medicine, University of Rome. He began his career in the United States the following year as an associate scientist at the Wistar Institute of Biology and Anatomy in Philadelphia. In 1980, he was named Wistar Professor of Genetics at the University of Pennsylvania and associate director of the Wistar Institute, titles he held until 1988. From 1988 to 1991, he was director of the Fels Institute for Cancer Research and Molecular Biology at Temple University School of Medicine in Philadelphia. In 1991, Dr. Croce was named Director of the Kimmel Cancer Center at Jefferson Medical College at the Thomas Jefferson University, in Philadelphia. Under his direction at Ohio State faculty within the Human Cancer Genetics Program conduct both clinical and basic research. Basic research projects focus on how genes are activated and inactivated, how cell‐growth signals are transmitted and regulated within cells, and how cells interact with the immune system. Clinical research focuses on discovering genes linked to cancer and mutations that predispose people to cancer. Dr. Croce, a member of the National Academy of Sciences in the US and the Accademia Nazionale delle Scienze detta deiXL in Italy, has received almost every significant award for cancer research that one can earn. He was awarded two Outstanding Investigator awards from the National Cancer Institute, the Richard and Hinda Rosenthal Foundation Award and the G.H.A. Clowes Memorial Award from the American Association for Cancer Research, the John Scott Award, the Robert J. and Claire Pasarow Foundation Cancer Award, the GM Cancer Research Foundation – Charles S. Mott Prize, the Scanno Prize for Medicine, the AACR‐Pezcoller Award, the Raymond Bourgine Award and Gold Medal of Paris and President of the Republic Prize, the iwCLL Binet‐Rai‐Medal for Outstanding Contribution to CLL Research, the Henry M. Stratton Medal from the American Society of Hematology, the Albert Szent‐Györgyi Prize for Progress in Cancer Research, the 2008 Leopold Griffuel Prize awarded by the French Association for Cancer Research, The Ernst W. Bertner Memorial Award, The University of Texas M.D. Anderson Cancer Center and most recently, an Elected Member of The American Academy of Arts and Sciences. He is principal investigator on seven federal research grants and has more than 875 peer‐reviewed, published research papers.