PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of ijnlThis JournalSearchAuthor GuidelinesAim and ScopeSubmit a ManuscriptIranian Journal of Neurology
 
Iran J Neurol. 2017 April 4; 16(2): 103–104.
PMCID: PMC5526776

A huge and invasive skull metastasis caused by renal cell carcinoma

A 65-year-old man presented by a progressive scalp mass from 9 months before. Physical examination showed a huge mass on his skull (Figure 1) associated with two small swellings in his axilla and flank.

Figure 1
The image of the patient's scalp

Neurological examination was normal. The laboratory data and preoperative evaluation was normal, too. The brain computed tomography (CT-scan) and magnetic resonance imaging (MRI) demonstrated a huge extra-axial mass in right parietal bone resulted to bone destruction and scalp invasion (Figures 2 and and3).3).

Figure 2
The bone window brain computed tomography (CT-scan)
Figure 3
The coronal T1, sagittal FLAIR, and coronal Gd-enhancement T1 image sequences of brain magnetic resonance imaging (MRI)

In surgery, there was a huge oval-shape hemorrhagic and firm mass associated with scalp invasion and bone destruction (Figure 4).

Figure 4
Intraoperative photograghy of the lesion

After skin incision, the mass was dissected from scalp and debulked; parietal craniectomy around the lesion was done; dura was opened and tumor was dissected from neural tissue and was resected totally. Helping synthetic patch and titanium mesh, the dura and skull were repaired. Histopathology revealed renal cell carcinoma (RCC).

Sepulveda, et al. reported a 62-year-old man presented with a large expansive and destructive mass within cranial base associated with bilateral internal carotid artery involvement. Incisional biopsy revealed clear cell adenocarcinoma in favor of renal tumor metastasis.1

Rekhi, et al. reported a 15-year-old girl presented with a painless swelling in the occipital region. She had a history of excisional biopsy with a diagnosis of an alveolar soft part sarcoma. The lesion recurred within one month. CT-scan revealed a vascular destructive skull mass compressed the cerebellum. Metastatic RCC was ascertained after excisional biopsy and systemic work up.2

Yeh, et al. presented an 80-year-old man admitted for an incidental mass on the left parietal. The CT-scan revealed a destructive soft tissue lesion in the left parietal with intracranial and scalp invasion. Needle biopsy demonstrated metastatic RCC.3

Koutnouyan, et al. reported a 33-year-old woman who was referred for a mass in forehead region as a benign lesion. Because of intraoperative severe bleeding and presence of bone erosion, only biopsy rather than resection was done. Histopathology and metastatic work-up demonstrated metastatic RCC.4

A metastatic lesion should be in differential diagnosis of a destructive skull lesion with brain and scalp invasion, although it occurs rarely.

Acknowledgments

None.

Conflict of Interests

The authors declare no conflict of interest in this study.

Notes:

How to cite this article: Babashahi A, Taheri M. A huge and invasive skull metastasis caused by renal cell carcinoma. Iran J Neurol 2017; 16(2): 103-4.

References

1. Sepulveda I, Platin E, Klaassen R, Spencer ML, Garcia C, Alarcon R, et al. Skull base clear cell carcinoma, metastasis of renal primary tumor: A case report and literature review. Case Rep Oncol. 2013;6(2):416–23. [PMC free article] [PubMed]
2. Rekhi B, Kumar R, Menon S, Medhi S, Desai SB. Calvarial metastasis of a renal cell carcinoma, mimicking a primary alveolar soft part sarcoma, in a young girl-a rare case report. Pathol Oncol Res. 2009;15(1):137–41. [PubMed]
3. Yeh HC, Yang SF, Ke HL, Lee KS, Huang CH, Wu WJ. Renal cell carcinoma presenting with skull metastasis: a case report and literature review. Kaohsiung J Med Sci. 2007;23(9):475–9. [PubMed]
4. Koutnouyan HA, Rumore GJ, Kahn JM. Skull metastasis from renal cell carcinoma. Case report and literature review. Ann Otol Rhinol Laryngol. 1998;107(7):598–602. [PubMed]

Articles from Iranian Journal of Neurology are provided here courtesy of Tehran University of Medical Sciences