Treatment with anti-T1/ST2 or anti-CCL11 has similar beneficial effects upon eosinophilic RSV disease. (a) Weight changes were monitored during RSV challenge of rVV-β gal (open symbols)- or rVV-G (filled symbols)-primed mice that were either mock treated (100 mg of normal rabbit Ig; circles) or given daily doses of 50 mg of anti-CCL11 (squares) or 100 mg of anti-T1/ST2 (triangles). Pulmonary infiltrates were sampled by BAL on day 6, and total cells (b), eosinophils (c), and CD4+ and CD8+ T cells (d; open and filled bars, respectively) were enumerated as described previously. Means ± SEM of four mice per group are shown. P values are represented as follows: *, P < 0.05; ns, not significant.
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