Treatment with anti-CCL11 during RSV challenge of rVV-G-primed mice reduces severity of illness and pulmonary eosinophilia. rVV-β gal (♦)- or rVV-G-primed mice were challenged with RSV on day 0. rVV-G-primed animals were given anti-CCL11 (○) or control Ig (•) daily. Mean weight loss (a) and mean illness scores (b) are presented for four to five mice per group. These data are representative of three separate experiments. Differential counts were performed with hematoxylin-and-eosin-stained cytospin preparations of BAL cells from individual mice and were used to determine proportions (c) and total numbers (d) of eosinophils. Combined data from four independent experiments are shown, together with means ± SEM for each group. **, P < 0.01.
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