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Logo of arthrestherBioMed Centralbiomed central web sitesearchsubmit a manuscriptregisterthis articleArthritis Research & Therapy
Arthritis Res Ther. 2004; 6(5): 225–233.
Published online 2004 August 16. doi:  10.1186/ar1227
PMCID: PMC546292

Biology of recently discovered cytokines: Discerning the pro- and anti-inflammatory properties of interleukin-27


IL-27 is a recently identified heterodimeric cytokine produced in response to microbial and host derived inflammatory cues. Initial studies indicated that IL-27 promotes the generation of Th1 responses required for resistance to intracellular infection and unveiled the molecular mechanisms mediating this effect. However, subsequent work uncovered a role for IL-27 in the suppression of Th1 and Th2 responses. Thus, by discussing its pleotropic functions in the context of infection-induced immunity and by drawing parallels to fellow IL-6/IL-12 family cytokines, this review will attempt to reconcile the pro- and anti-inflammatory effects of IL-27.

Keywords: IL-27, WSX-1, Th1, Th2, infection

Articles from Arthritis Research & Therapy are provided here courtesy of BioMed Central