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Curr Neuropharmacol. 2017 February; 15(2): 195.
Published online 2017 February. doi:  10.2174/1570159X1502170104204144
PMCID: PMC5412703

Meet Our Editorial Board Member

Professor Guy Caldwell is a University Distinguished Research Professor at The University of Alabama. He also holds joint appointments at the University of Alabama School of Medicine in Birmingham (UAB) as an Adjunct Research Professor of Neurology and Neurobiology. Prof. Caldwell received his undergraduate degree in Biology from Washington & Lee University in 1986 and his Ph.D. in Cell, Molecular & Developmental Biology from the University of Tennessee in 1993. Following receipt of his doctorate, he moved to Columbia University in 1995 where he trained in the lab of 2008 Nobel Laureate, Dr. Martin Chalfie, and was twice named the recipient of fellowships from the National Institute of Neurological Disorders and Stroke. In 2003, Prof. Caldwell was chosen as the recipient of a CAREER Award from the National Science Foundation. Prof. Caldwell was a Basil O'Connor Scholar of The March of Dimes Birth Defects Foundation and has been a recipient of multiple grants from the NIH, Michael J. Fox Foundation, Dystonia Medical Research Foundation, Parkinson's Disease Foundation, American Parkinson Disease Association, National Parkinson Foundation, The Parkinson’s Institute, and the Bachmann-Strauss Dystonia & Parkinson Foundation. Jointly with his wife and research partner, Dr. Kim Caldwell, Guy Caldwell shared the inaugural HudsonAlpha Prize for Outstanding Innovation in the Life Sciences. For his teaching and mentoring efforts, Prof. Caldwell was honored in U.S. Congress with the 2005 Carnegie Foundation and Council for the Advancement and Support of Education (CASE) U.S. Professor of the Year award, one of only 40 professors across all universities in the United States.

Prof. Caldwell serves on the Editorial Boards of Human Molecular Genetics, Disease Models and Mechanisms, ACS Chemical Neuroscience, and Current Neuropharmacology and was a member of the Scientific Advisory and Grant Review Boards of the Bachmann-Strauss Dystonia & Parkinson Foundation and the Parkinson’s Disease Foundation. He has regularly served as a manuscript reviewer for over 30 journals, as well as an ad hoc grant reviewer for the NIH, NSF, and various medical foundations. He is also the author of three textbooks in the fields of biotechnology and genomics, marketed worldwide in four languages.

His research program focuses on the application of the nematode model system, C. elegans, as a model for neurological diseases. Recent studies are aimed at taking advantage of this animal for accelerating the translational path for functional characterization of disease-modifying targets and molecules to attenuate neuronal dysfunction in dystonia, as well as neurodegeneration in Parkinson’s and Alzheimer’s disease.

SELECTED PUBLICATIONS

1. Cooper A.A., Gitler A.D., Cashikar A., Haynes C.M., Hill K.J., Bhullar B., Liu K., Xu K., Strathearn K.E., Liu F., Cao S., Caldwell K.A., Caldwell G.A., Marsischky G., Kolodner R.D., Labaer J., Rochet J.C., Bonini N.M., Lindquist S. Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science. 2006;313(5785):324–328. [PMC free article] [PubMed]
2. Hamamichi S., Rivas R.N., Knight A.L., Cao S., Caldwell K.A., Caldwell G.A. Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model. Proc. Natl. Acad. Sci. USA. 2008;105(2):728–733. [PubMed]
3. Chen P., Burdette A.J., Porter J.C., Ricketts J.C., Fox S.A., Nery F.C., Hewett J.W., Berkowitz L.A., Breakefield X.O., Caldwell K.A., Caldwell G.A. The early-onset torsion dystonia-associated protein, torsin A, is a homeostatic regulator of endoplasmic reticulum stress response. Hum. Mol. Genet. 2010;19(18):3502–3515. [PMC free article] [PubMed]
4. Treusch S., Hamamichi S., Goodman J.L., Matlack K.E., Chung C.Y., Baru V., Shulman J.M., Parrado A., Bevis B.J., Valastyan J.S., Han H., Lindhagen-Persson M., Reiman E.M., Evans D.A., Bennett D.A., Olofsson A., DeJager P.L., Tanzi R.E., Caldwell K.A., Caldwell G.A., Lindquist S. Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast. Science. 2011;334(6060):1241–1245. [PMC free article] [PubMed]
5. Mazzulli J.R., Xu Y.H., Sun Y., Knight A.L., McLean P.J., Caldwell G.A., Sidransky E., Grabowski G.A., Krainc D. Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies. Cell. 2011;146(1):37–52. [PMC free article] [PubMed]
6. Tardiff D.F., Jui N.T., Khurana V., Tambe M.A., Thompson M.L., Chung C.Y., Kamadurai H.B., Kim H.T., Lancaster A.K., Caldwell K.A., Caldwell G.A., Rochet J.C., Buchwald S.L., Lindquist S. Yeast reveal a “druggable” Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. Science. 2013;342(6161):979–983. [PMC free article] [PubMed]
7. Harrington A.J., Yacoubian T.A., Slone S.R., Caldwell K.A., Caldwell G.A. Functional analysis of VPS41-mediated neuroprotection in Caenorhabditis elegans and mammalian models of Parkinson's disease. J. Neurosci. 2012;32(6):2142–2153. [PubMed]
8. Knight A.L., Yan X., Hamamichi S., Ajjuri R.R., Mazzulli J.R., Zhang M.W., Daigle J.G., Zhang S., Borom A.R., Roberts L.R., Lee S.K., DeLeon S.M., Viollet-Djelassi C., Krainc D., O'Donnell J.M., Caldwell K.A., Caldwell G.A. The glycolytic enzyme, GPI, is a functionally conserved modifier of dopaminergic neurodegeneration in Parkinson's models. Cell Metab. 2014;20(1):145–157. [PMC free article] [PubMed]
9. Jackrel M.E., DeSantis M.E., Martinez B.A., Castellano L.M., Stewart R.M., Caldwell K.A., Caldwell G.A., Shorter J. Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events. Cell. 2014;156:170–182. [PMC free article] [PubMed]

Articles from Current Neuropharmacology are provided here courtesy of Bentham Science Publishers