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Front Psychiatry. 2017; 8: 51.
Published online 2017 April 6. doi:  10.3389/fpsyt.2017.00051
PMCID: PMC5382199

Effect of Case Management Interventions for Patients with Substance Use Disorders: A Systematic Review

Abstract

Background

Substance use disorder (SUD) is an important health problem that requires a complex range of care because of the chronic nature of the disorder and the multiple psychosocial problems involved. Current outpatient programs often have difficulties in delivering and coordinating ongoing care and access to different health-care providers. Various case management (CM) models have been developed, first for patients in other psychiatric domains and then for patients with SUD, in order to improve treatment outcomes.

Aim

This paper aims to assess the effectiveness of CM for patients with SUD.

Methods

We performed a systematic review of CM interventions for patients with SUD by analyzing randomized controlled studies published on the subject between 1996 and 2016 found on the electronic database PubMed.

Results and conclusion

Fourteen studies were included in the analysis. Differences between studies in outcome measures, populations included, and intervention characteristics made it difficult to compare results. Most of these studies reported improvement in some of the chosen outcomes. Treatment adherence mostly improved, but substance use was reported to decrease in only a third of the studies. Overall functioning improved in about half of the studies. The heterogeneity of the results might be linked to these differences between studies. Further research is needed in the field.

Keywords: case management, assertive community treatment, substance use disorder, substance abuse, alcohol use disorder

Introduction

Substance use disorders (SUDs), which include drug abuse, problematic drug use, drug misuse, and substance misuse, are an important health problem (1). Persons with SUDs are characterized by multiple social and medical needs and are often known for their difficulty in engaging in treatment, partly because access to treatment facilities is limited (2). The chronicity and relapsing nature of SUD, as in other psychiatric disorders, entails frequent hospitalizations (3) and readmissions.

Patients presenting both severe mental illnesses and SUD are typically hospitalized more often than are non-substance users (4, 5). Patients presenting this double diagnosis also have more difficulties entering alcohol and drug outpatient clinics than patients with only SUD (6). This group of patients seems to have less access to aftercare services (7) and higher use of acute services, such as emergency room treatment and hospital services (8).

The period after discharge is characterized by a high risk of relapse, with most cases occurring within the first week of inpatient treatment (9). There is also an important risk of drug-related death (either accidental or intended) following a longer period of abstinence because of lower drug tolerance (10, 11). These patients have multiple psychosocial problems for which they need support. Patient needs often remain unmet in current outpatient treatment programs (2), although the provision of help with legal advice, basic needs, and family services may improve patients’ psychosocial functioning. Treatment continuity has been related to higher overall abstinence rates (12, 13) and less frequent readmissions to hospital units (14). Between hospital and community care, treatment continuity is supposed to improve comprehensive support for patients.

Different strategies have been developed to improve treatment adherence and drug-related outcomes (15); among them, case management (CM) has been identified as potentially beneficial as suggested in early clinical studies (16). The definition of CM and its practice varies from place to place. In general, CM can be defined as a “coordinated integrated approach to service delivery, ongoing supportive care and help to access resources for living and functioning in the community” (17). This approach has been widely implemented in many different areas, such as insurance programs, education, and health care.

Given the complex, chronic, and relapsing nature of mental health disorders and SUDs, they require a broad and continuous approach such as can be offered by CM (17). Since the 1980s, this practice has been adapted for persons with SUD (18), but to date, only a few studies have described CM models for persons with SUD in Europe.

The aim of this study was thus to assess the effectiveness of CM for patients with SUD. We searched for published articles in which clinical CM was described for patients with SUD to help maintain treatment continuity and coordinate care after a patient was discharged from hospital or prison (transitional CM) or when a patient entered a treatment program.

Method

The electronic database PubMed was searched for empirical studies published between January 1996 and May 2016. The following keywords were used: “case management” AND “addiction”; “case management” AND “substance use disorder”; “case management” AND “substance abuse.” The inclusion criteria were as follows: randomized controlled trial, adult participants over the age of 18 years with SUD, and a CM intervention compared to treatment as usual (TAU).

Results

After checking for the inclusion criteria and for duplicates, we analyzed 14 studies (Figure (Figure1).1). Details about the included studies are described in Table Table1.1. One paper (19) was reviewed but excluded. It compared assertive community treatment to another form of CM intervention. In absence of a TAU comparison group, the study was not included.

Figure 1
Study flow diagram.
Table 1
Characteristics of the included studies.

The names of CM interventions varied in different studies. They were labeled “intensive,” “community,” or “assertive CM” (2022); “strengths-based” (2326), “clinical” (27), and “transitional CM” (28); or “coordinated care management” (29) and “probation CM” (30). Although the names and interventions varied, certain common characteristics could be found. CM services were conducted by case managers with a professional background in nursing, social work, or mental health care (22). CM services were delivered mainly in the patients’ communities and not at the treatment center or hospital (2022). The length of interventions varied from 1 month (25) to 3 years (20), although 6 months to 1 year was the most common. The intensity of the CM intervention was rarely noted.

Study Populations

In some studies, the population had SUD and no further differentiation was made, whereas other studies considered specific subgroups such as patients in methadone programs (27), women with SUD (22, 31, 32), and participants with court judgments who were either incarcerated or in court-ordered treatments (23, 28, 30). Most studies were done in the United States, except for the one by Prendergast et al. (28) in Canada and Lindhal et al. (23) in Sweden.

Outcome Measures

The most frequently used outcome measures were change in drug or alcohol use, as well as adherence to SUD treatment (frequently measured in attendance rates) and linkage to other health-care providers. The other important outcome measures were health-care use in terms of days of hospitalization, emergency ward visits, or health costs. On a more general level, some studies measured global functioning; employment rates; reduction of social, legal, and family problems; and client satisfaction. Two studies concerning incarcerated or court-ordered individuals also used the number of post-enrollment arrests as an outcome measure (28, 30).

Most studies considered only SUD as an inclusion criterion. Surprisingly, the importance of comorbid mental health disorders or high service use was not defined as an inclusion criterion in most studies. Slesnick and Erdam’s study (32) included only homeless mothers, and Morgenstern et al.’s studies (22, 29, 31) analyzed patients receiving welfare [in one study (22), only women were included]. Only Essock et al.’s study (20) used high service use, severe comorbid mental health disorder, unstable housing, and poor living skills as inclusion criteria. Some studies even excluded psychotic disorders (22, 24), and Morgenstern et al.’s study (29) excluded patients who had been hospitalized more than once for mental health reasons in the past year.

Effect of the Intervention

Only two studies (28, 30) did not find any additional value in CM when treating addicted patients. The other 12 papers found significant improvement of some or all the outcome measures. These improvements were not the same for each survey.

Five studies showed that substance use decreased (20, 22, 23, 27, 32), two papers (22, 26) showed that the likelihood of initiating SUD treatment increased, and four publications (22, 23, 27, 33) showed greater treatment retention when a case manager was involved in treatment. Four studies (23, 24, 33, 34) showed improved access to health care and/or linkage between health-care providers. One research showed fewer days spent in hospital (20) but others reported an increased number of days in hospital, which is explained by the higher treatment retention (34). Seven publications showed better global functioning, which was described as more employment days (25, 31, 35). This was further differentiated in Morgenstern et al.’s study of 2008 (29), which showed that women were more likely than men to find employment when assisted by CM, to have fewer legal (21, 35) and family problems (21), and to have better housing stability (32). Lindahl et al. measured very high patient satisfaction with the treatment and 100% treatment retention compared to TAU (23).

Discussion

In most studies, significant improvements were reported in the outcome measures. Substance use decreased in only five papers (20, 22, 23, 27, 32), but treatment adherence and linkage between health-care providers seemed to improve in most surveys, which is an important issue for this population and one of the main aims of CM. Overall functioning improved in more than half of the studies, which is in general linked to higher life satisfaction.

The two publications (28, 30) that did not find significant improvements in one of the outcome measures were both performed with incarcerated or paroled patients. In Guydish et al.’s paper (30), the important factor was the limited face-to-face time. Only 53.6% of participants had seen their CM once or more during the first 6 months. For those participants who had seen their CM two or more times in the first 6 months, there was an improvement in substance use and social problems. This finding shows how important treatment intensity of CM is for the outcome. The other study with a negative outcome, by Prendergast et al. (28), showed no improvement in treatment participation for parolees with SUD who were receiving CM. However, this finding cannot be generalized, as the case manager’s adherence to the protocol and the intervention was not standardized. Moreover, the case manager seemed to have limited contact with the parolee and the parolees did not enroll voluntarily in the project.

The studies are heterogeneous in their clinical approach, which limits our ability to generalize specific implications for practice. Different types of populations with different risk levels seem to account for the variation in readmission rates (36). For example, the study populations varied in illness severity (comorbidities and service use), which would most likely have an effect on the study outcome. Some comorbid populations were also excluded from surveys. The CM model is a specific intervention that seems more useful to specific subgroups who are unable to use existing health-care services. A large number of patients find adequate health care in the usual care programs, as shown in research on CM interventions that involve psychiatric patients with psychosis. Patients who benefit from CM have been shown to be those with greater social and psychosocial needs, more psychiatric symptoms, and higher service use (37), with others not needing this specific intensive care (38). If CM is applied to a large group, the effect on a smaller subgroup would likely be diluted and not as visible in the outcome measures. It will be important to further specify these subgroups in future in order to refer patients to the appropriate programs.

The intensity of application of CM differs in these studies, which also limits our ability to generalize the effects (39). These examples show the importance of face-to-face time with patients, which can be managed only with small caseloads. This seems to have been a limiting factor in the two studies (28, 30) mentioned above. In addition, the adherence to the model by the case manager and the voluntary participation of the patients seem to affect the outcome.

The majority of the studies were performed in the United States, which is a limiting factor in generalizing these findings to other countries such as those in Europe, where health systems differ in organization and funding. A further limitation of this research was that the data search was performed only on the PubMed database and possibly that unpublished negative studies were not taken into account. Furthermore, we did not differentiate between alcohol use disorder and other SUDs.

Conclusion

Most of the analyzed studies showed improvement in the chosen outcome measures, although these varied in different studies. Treatment adherence mostly improved, but substance use decreased in only a third of the studies. Overall functioning improved in about half of the studies. The differences in chosen outcome measures make it difficult to compare the results. The type of intervention and intensity of treatment also varied.

The heterogeneity of these results might be linked to the different types of populations studied. The specific CM intervention seems to be helpful only for specific subpopulations with SUDs. Further studies are necessary to determine inclusion criteria for CM treatment for patients with SUD in order to orientate those most likely to benefit from this approach to the specific CM programs.

Only a few studies on this intervention and SUD have been published. Further research is needed to examine the effect of treatment intensity of the CM intervention. Longitudinal studies are also needed in Europe to ensure the effectiveness of these treatments.

Author Contributions

LP, AM, and YK designed the strategy for the present review and drafted the manuscript. AM and LP searched for the references and read the manuscripts. LP, AM, and YK discussed the results. All authors reviewed the manuscript and helped with the final writing.

Conflict of Interest Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

1. Degenhardt L, Hall W.. Extent of illicit drug use and dependence, and their contribution to the global burden of disease. Lancet (2012) 379:55–70.10.1016/S0140-6736(11)61138-0 [PubMed] [Cross Ref]
2. Pringle JL, Emptage NP, Hubbard RL.. Unmet needs for comprehensive services in outpatient addiction treatment. J Subst Abuse Treat (2006) 30:183–9.10.1016/j.jsat.2005.11.006 [PubMed] [Cross Ref]
3. Bonsack C, Gibellini S, Ferrari P, Dorogi Y, Morgan C, Morandi S, et al. Le case management de transition: Une intervention à court terme dans la communauté après une hospitalisation psychiatrique. Schweiz Arch Neurol Psychiatr (1985) (2009) 160:246–52.
4. Bartels SJ, Teague GB, Drake RE, Clark RE, Bush PW, Noordsy DL.. Substance abuse in schizophrenia: service utilization and costs. J Nerv Ment Dis (1993) 181:227–32.10.1097/00005053-199304000-00003 [PubMed] [Cross Ref]
5. Cuffel BJ, Chase P.. Remission and relapse of substance use disorders in schizophrenia. Results from a one-year prospective study. J Nerv Ment Dis (1994) 182:342–8.10.1097/00005053-199406000-00006 [PubMed] [Cross Ref]
6. Narrow WE, Regier DA, Rae DS, Manderscheid RW, Locke BZ.. Use of services by persons with mental and addictive disorders: findings from the National Institute of Mental Health Epidemiologic Catchment Area Program. Arch Gen Psychiatry (1993) 50:95–107.10.1001/archpsyc.1993.01820140017002 [PubMed] [Cross Ref]
7. Haugland G, Siegel C, Alexander MJ, Galanter M.. A survey of hospitals in New York State treating psychiatric patients with chemical abuse disorders. Psychiatr Serv (1991) 42:1215–20.10.1176/ps.42.12.1215 [PubMed] [Cross Ref]
8. Havassy BE, Shopshire MS, Quigley LA.. Effects of substance dependence on outcomes of patients in a randomized trial of two case management models. Psychiatr Serv (2000) 51:639–44.10.1176/appi.ps.51.5.639 [PubMed] [Cross Ref]
9. Smyth BP, Barry J, Keenan E, Ducray K.. Lapse and relapse following inpatient treatment of opiate dependence. Ir Med J (2010) 103:176–9. [PubMed]
10. Ravndal E, Amundsen EJ.. Mortality among drug users after discharge from inpatient treatment: an 8-year prospective study. Drug Alcohol Depend (2010) 108:65–9.10.1016/j.drugalcdep.2009.11.008 [PubMed] [Cross Ref]
11. Merrall EL, Bird SM, Hutchinson SJ. A record-linkage study of drug-related death and suicide after hospital discharge among drug-treatment clients in Scotland, 1996–2006. Addiction (2013) 108:377–84.10.1111/j.1360-0443.2012.04066.x [PubMed] [Cross Ref]
12. Schaefer JA, Harris AH, Cronkite RC, Turrubiartes P.. Treatment staff’s continuity of care practices, patients’ engagement in continuing care, and abstinence following outpatient substance-use disorder treatment. J Stud Alcohol Drugs (2008) 69:747–56.10.15288/jsad.2008.69.747 [PubMed] [Cross Ref]
13. Parmenter J, Mitchell C, Keen J, Oliver P, Rowse G, Neligan I, et al. Predicting biopsychosocial outcomes for heroin users in primary care treatment: a prospective longitudinal cohort study. Br J Gen Pract (2013) 63:e499–505.10.3399/bjgp13X669220 [PMC free article] [PubMed] [Cross Ref]
14. Raven MC, Carrier ER, Lee J, Billings JC, Marr M, Gourevitch MN.. Substance use treatment barriers for patients with frequent hospital admissions. J Subst Abuse Treat (2010) 38:22–30.10.1016/j.jsat.2009.05.009 [PubMed] [Cross Ref]
15. Broekaert E, Vanderplasschen W.. Towards the integration of treatment systems for substance abusers: report on the second International Symposium on Substance Abuse Treatment and Special Target Groups. J Psychoactive Drugs (2003) 35:237–45.10.1080/02791072.2003.10400005 [PubMed] [Cross Ref]
16. McLellan AT, Hagan TA, Levine M, Meyers K, Gould F, Bencivengo M, et al. Does clinical case management improve outpatient addiction treatment. Drug Alcohol Depend (1999) 55:91–103.10.1016/S0376-8716(98)00183-5 [PubMed] [Cross Ref]
17. Vanderplasschen W, Rapp RC, Wolf JR, Broekaert E.. The development and implementation of case management for substance use disorders in North America and Europe. Psychiatr Serv (2004) 55:913–22.10.1176/appi.ps.55.8.913 [PMC free article] [PubMed] [Cross Ref]
18. Graham K, Timney CB.. Case management in addictions treatment. J Subst Abuse Treat (1990) 7:181–8.10.1016/0740-5472(90)90020-Q [PubMed] [Cross Ref]
19. Clark RE, Teague GB, Ricketts SK, Bush PW, Xie H, McGuire TG, et al. Cost-effectiveness of assertive community treatment versus standard case management for persons with co-occurring severe mental illness and substance use disorders. Health Serv Res (1998) 33:1285–308. [PMC free article] [PubMed]
20. Essock SM, Mueser KT, Drake RE, Covell NH, McHugo GJ, Frisman LK, et al. Comparison of ACT and standard case management for delivering integrated treatment for co-occurring disorders. Psychiatr Serv (2006) 57:185–96.10.1176/appi.ps.57.2.185 [PubMed] [Cross Ref]
21. Huber DL, Sarrazin MV, Vaughn T, Hall JA.. Evaluating the impact of case management dosage. Nurs Res (2003) 52:276–88.10.1097/00006199-200309000-00002 [PubMed] [Cross Ref]
22. Morgenstern J, Blanchard KA, McCrady BS, McVeigh KH, Morgan TJ, Pandina RJ.. Effectiveness of intensive case management for substance-dependent women receiving temporary assistance for needy families. Am J Public Health (2006) 96:2016–23.10.2105/AJPH.2005.076380 [PubMed] [Cross Ref]
23. Lindahl ML, Berglund M, Tonnesen H.. Case management in aftercare of involuntarily committed patients with substance abuse. A randomized trial. Nord J Psychiatry (2013) 67:197–203.10.3109/08039488.2012.704068 [PubMed] [Cross Ref]
24. Rapp RC, Otto AL, Lane DT, Redko C, McGatha S, Carlson RG.. Improving linkage with substance abuse treatment using brief case management and motivational interviewing. Drug Alcohol Depend (2008) 94:172–82.10.1016/j.drugalcdep.2007.11.012 [PMC free article] [PubMed] [Cross Ref]
25. Siegal HA, Fisher JH, Rapp RC, Kelliher CW, Wagner JH, O’Brien WF, et al. Enhancing substance abuse treatment with case management. Its impact on employment. J Subst Abuse Treat (1996) 13:93–8.10.1016/0740-5472(96)00029-3 [PubMed] [Cross Ref]
26. Strathdee SA, Ricketts EP, Huettner S, Cornelius L, Bishai D, Havens JR, et al. Facilitating entry into drug treatment among injection drug users referred from a needle exchange program: results from a community-based behavioral intervention trial. Drug Alcohol Depend (2006) 83:225–32.10.1016/j.drugalcdep.2005.11.015 [PMC free article] [PubMed] [Cross Ref]
27. Plater-Zyberk CJ, Varenbut M, Daiter J, Worster A.. The value of clinical case management in a methadone maintenance treatment program. Am J Drug Alcohol Abuse (2012) 38:70–2.10.3109/00952990.2011.600391 [PubMed] [Cross Ref]
28. Prendergast M, Frisman L, Sacks JY, Staton-Tindall M, Greenwell L, Lin HJ, et al. A multi-site, randomized study of strengths-based case management with substance-abusing parolees. J Exp Criminol (2011) 7:225–53.10.1007/s11292-011-9123-y [PMC free article] [PubMed] [Cross Ref]
29. Morgenstern J, Hogue A, Dauber S, Dasaro C, McKay JR. Does coordinated care management improve employement for substance-using welfare recipients? J Stud Alcohol Drugs (2009) 70:955–63. [PubMed]
30. Guydish J, Chan M, Bostrom A, Jessup M, Davis T, Marsh C.. A randomized trial of probation case management for drug-involved women offenders. Crime Delinq (2011) 57:167–98.10.1177/0011128708318944 [PMC free article] [PubMed] [Cross Ref]
31. Morgenstern J, Neighbors CJ, Kuerbis A, Riordan A, Blanchard KA, McVeigh KH, et al. Improving 24-month abstinence and employment outcomes for substance-dependent women receiving temporary assistance for needy families with intensive case management. Am J Public Health (2009) 99:328–33.10.2105/AJPH.2007.133553 [PubMed] [Cross Ref]
32. Slesnick N, Erdem G.. Efficacy of ecologically-based treatment with substance-abusing homeless mothers: substance use and housing outcomes. J Subst Abuse Treat (2013) 45:416–25.10.1016/j.jsat.2013.05.008 [PMC free article] [PubMed] [Cross Ref]
33. Scott CK, Sherman RE, Foss MA, Godley M, Hristova L.. Impact of centralized intake on case management services. J Psychoactive Drugs (2002) 34:51–7.10.1080/02791072.2002.10399936 [PubMed] [Cross Ref]
34. Saleh SS, Vaughn T, Hall J, Levey S, Fuortes L, Uden-Holmen T.. The effect of case management in substance abuse on health services use. Care Manag J (2003) 4:82–7. [PubMed]
35. Saleh SS, Vaughn T, Hall J, Levey S, Fuortes L, Uden-Holmen T.. Effectiveness of case management in substance abuse treatment. Care Manag J (2002) 3:172–7.10.1891/cmaj.3.4.172.57448 [PubMed] [Cross Ref]
36. Vigod SN, Taylor VH, Fung K, Kurdyak PA. Within-hospital readmission: an indicator of readmission after discharge from psychiatric hospitalization. Can J Psychiatry (2013) 58:476–81.10.1177/070674371305800806 [PubMed] [Cross Ref]
37. Mas-Expósito L, Amador-Campos JA, Gómez-Benito J, Lalucat-Jo L.. Considering variables for the assignment of patients with schizophrenia to a case management programme. Community Ment Health J (2013) 49:831–40.10.1007/s10597-013-9621-7 [PubMed] [Cross Ref]
38. Alameda L, Golay P, Baumann P, Morandi S, Ferrari C, Conus P, et al. Assertive outreach for “difficult to engage” patients: a useful tool for a subgroup of patients in specialized early psychosis intervention programs. Psychiatry Res (2016) 239:212–9.10.1016/j.psychres.2016.03.010 [PubMed] [Cross Ref]
39. Joo JY, Huber DL.. Community-based case management effectiveness in populations that abuse substances. Int Nurs Rev (2015) 62:536–46.10.1111/inr.12201 [PubMed] [Cross Ref]

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