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Yale J Biol Med. 2017 March; 90(1): 158–159.
Published online 2017 March 29.
PMCID: PMC5369037
Focus: Drug Development

Applying Pharmacogenomics in Therapeutics

Xiaodong Feng, Hong-Guang Xie, editors.
Applying Pharmacogenomics in Therapeutics.
2016. CRC Press (Taylor & Francis Group): Boca Raton, Florida. ISBN: (Hardcover) 978-1466582675. US $129.95. 294 p.

Applying Pharmacogenomics in Therapeutics introduces the principles of pharmacogenomics and personalized medicine in our new century of omics biotechnology. This book covers the fundaments, clinical practices, and applications of precise drug therapy. In their preface, Xiaodong and Hong-Guang state that the birth of pharmacogenomics promotes the development of precision medicine, “the major purpose of which is to improve health and treat diseases.” They use many examples of clinical applications of pharmacogenomics in drug therapy of cancer, cardiovascular and pulmonary diseases, and neurologic and psychiatric disorders.

The book introduces up-to-date principles and concepts of pharmacology, genomics, and the combination in pharmacogenomics as an excellent reference book. It covers the basic methods of biotechnology and biomarkers of genetic and genomic testing in a precise and simple manner to understand the concepts of pharmacogenomics in clinical practice. The authors enumerate relevant clinical applications and recent therapeutic interventions of how to improve in diagnosis and drug targeting by understanding the sequence of the DNA of patients. Therefore, the knowledge and interpretation of tests in pharmacogenomics are critical for drug safety and efficacy as well as future advancement in health care. The book exemplifies clinical cases of genetic variants in several diseases, defining genetic determinants for drug response and thoroughly describes the applications and therapy in clinical practice. Finally, the authors connect pharmacogenomics with the generation of cost-effectiveness treatments.

Applying Pharmacogenomics in Therapeutics is intended for graduate, medical school courses. or healthcare professionals with a deep focus on genomics, pharmacy, pharmacology, and clinical care practice. Healthcare providers and research scientists would benefit from this text as a reference tool of the recent advances in this field. This text is well written and provides useful examples, tables and clinical cases to better understand and practice the concepts being described. Each chapter begins with a short list of key concepts, an introduction to the topic of the chapter, and concludes with a summary and study questions to practice. The book facilitates an extensive number of references per chapter to educate in depth and to provide tools to increase research and knowledge to the readers. Overall, this text is a comprehensive presentation of the recent approaches in personalized therapy based on genome sequencing and pharmacology combination.


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