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To the Editor,
It is very much appreciated that Dr. Juan-Carlos Argüelles has critiqued our review of the trehalose pathway as an antifungal target.1,2 In his letter, he cogently has emphasized and identified several issues which are important to the creation and completion of trehalose and its enzymes as fungicidal targets. This enthusiasm to exploit this pathway is clearly expressed by the critique. In fact, in his title that includes the statement, “the picture is still incomplete,” he has issued the challenge that our review tried to articulate. It is true that the “picture is not yet a masterpiece.” This result will occur when we have discovered a potent antifungal agent at this mechanistic site. We hope our review suggests that it is both possible and of outstanding worth to complete this picture.
No potential conflicts of interest were disclosed.