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Logo of actae2this articlesearchopen accesssubmitActa Crystallographica Section E: Crystallographic CommunicationsActa Crystallographica Section E: Crystallographic Communications
 
Acta Crystallogr E Crystallogr Commun. 2017 March 1; 73(Pt 3): 378–382.
Published online 2017 February 14. doi:  10.1107/S2056989017002213
PMCID: PMC5347059

Crystal structure and solvent-dependent behaviours of 3-amino-1,6-diethyl-2,5,7-trimethyl-4,4-di­phenyl-3a,4a-di­aza-4-bora-s-indacene

Abstract

In the title compound (3-amino-4,4-diphenyl-BODIPY), C28H32BN3, the central six-membered ring has a flattened sofa conformation, with one of the N atoms deviating by 0.142 (4) Å from the mean plane of the other five atoms, which have an r.m.s. deviation of 0.015 Å. The dihedral angle between the two essentially planar outer five-membered rings is 8.0 (2)°. In the crystal, mol­ecules are linked via weak N—H(...)π inter­actions, forming chains along [010]. The com­pound displays solvent-dependent behaviours in both NMR and fluorescence spectroscopy. In the 1H NMR spectra, the aliphatic resonance signals virtually coalesce in solvents such as chloro­form, di­chloro­methane and di­bromo­ethane; however, they are fully resolved in solvents such as dimethyl sulfoxide (DMSO), methanol and toluene. The excitation and fluorescence intensities in chloro­form decreased significantly over time, while in DMSO the decrease is not so profound. In toluene, the excitation and fluorescent intensities are not time-dependent. This behaviour is presumably attributed to the assembly of 3-amino-4,4-diphenyl-BODIPY in solution that leads to the formation of noncovalent structures, while in polar or aromatic solvents, the formation of these assemblies is disrupted, leading to resolution of signals in the NMR spectra.

Keywords: crystal structure, BODIPY, excitation and emission, fluorescence, NMR spectroscopy, solvent dependence

Chemical context  

4,4-Di­fluoro-3a,4a-di­aza-4-bora-s-indacene (BODIPY, see Scheme 1), as an attractive fluoro­phore, has found many applications in material sciences, as sensors and in labelling biomolecules such as proteins, lipids and nucleic acids (Ulrich et al., 2008  ; Loudet & Burgess, 2007  ; Ziessel et al., 2007  ; Tram et al., 2011  ; Lu et al., 2014  ; Bessette & Hanan, 2014  ). In our efforts to develop new BODIPY labelling chemistry, BODIPY analogues bearing an amino group, such as 3-amino-4,4-di­fluoro- and 3-amino-4,4-diphenyl-BODIPY, are being sought. While 3-amino-4,4-di­fluoro-BODIPY has been synthesized pre­viously (Liras et al., 2007  ), a unique solvent-dependent behaviour of 3-amino-4,4-diphenyl-BODIPY, but not 3-amino-4,4-di­fluoro-BODIPY, was observed by NMR. In this regard, the resonance signals of the aliphatic protons are fully resolved in solvents such as DMSO-d 6, but coalesced in solvents such as CDCl3. We herein report the solvent-dependent behaviour of 3-amino-4,4-diphenyl-BODIPY analogues as observed in the 1H NMR and in excitation and emission spectroscopy. The crystal structure suggests that the title compound could form noncolvalent assemblies in solvents such as CDCl3, leading to its solvent-dependent behaviours in NMR and fluorescence spectroscopy.

Synthesis of BODIPY 2b  

The presence of an amino group in BODIPY allows for functional-group transformation and potential applications in labelling biomolecules. Towards the synthesis of amino BODIPY, an intriguing chemistry was recently described (Liras et al., 2007  ). In this chemistry, a one-pot reaction of a substituted pyrrole in the presence of sodium nitrite, acetic acid and acetic anhydride, followed by treatment with boron trifluoride dietherate, led to the formation of a mixture of amino 2a and acetimido BODIPY 3a (see Scheme 2, R = F). Following this approach, 3-amino-1,6-diethyl-2,5,7-trimethyl-4,4-diphenyl-3a,4a-di­aza-4-bora-s-indacene (BODIPY 2b, see Scheme 2 and Fig. 1  ) was synthesized in very low yield (typically <5%), where boron trifluoride diethyl etherate was replaced with di­phenyl­boron bromide (Scheme 2, R = Ph).

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Object name is e-73-00378-scheme1.jpg

Figure 1
The mol­ecular structure of the title compound, with displacement ellipsoids drawn at the 30% probabilty level. H atoms are not shown.

Solvent-dependent behaviour of BODIPY 2b observed by NMR spectroscopy  

The characterization of 2b by 1H NMR spectroscopy yielded intriguing results. While the proton signals in 1H NMR spectra are fully resolved in DMSO-d 6 (as in Fig. 2  f), the aliphatic protons are completely coalesced in CDCl3. It is also observed that gradual addition of CDCl3 to a solution of 2b in DMSO-d 6 led to a loss of resolution of the aliphatic protons (Figs. 2  be).

Figure 2
1H NMR spectra of BODIPY 2 b in DMSO-d 6 or mixtures of CDCl3 and DMSO-d 6 in varying ratios: (a) DMSO-d 6/CDCl3 (1:2 v/v); (b) DMSO-d 6/CDCl3 (1:1 v/v); (c) DMSO-d 6/CDCl3 (5:2 v/v); (d) DMSO-d 6/CDCl3 (5:1 v/v); (e) DMSO-d 6/CDCl3 (10:1 v/ ...

In deuterated di­chloro­methane and 1,2-di­bromo­ethane, the 1H NMR spectra are similarly coalesced (data not shown). On the other hand, spectra are resolved in deuterated methanol and toluene (data not shown), despite the poor solubility of 2b in methanol. These observations prompted us to further investigate the absorption and fluorescent emission behaviour of BODIPY 2b in solution.

Solvent-dependent behavior of BODIPY 2b observed by fluorescence spectroscopy  

Fig. 3  (a) suggests that the fluorescence spectra of 2b in chloro­form, and to some extend in DMSO as well, shows time-dependent fluorescent intensities. In contrast, most solvatochromic BODIPY fluoro­phores that have been reported in the literature often show different maximal emission wavelengths (Baruah et al., 2006  ; Clemens et al., 2008  ; Filarowski et al., 2010  , 2015  ; de Rezende et al., 2014  ), however, those solvatochromic BODIPY dyes do not display a time-dependent change in fluorescent intensity.

An external file that holds a picture, illustration, etc.
Object name is e-73-00378-scheme2.jpg

Figure 3
Excitation and emission profile of 3-amino-4,4-diphenyl-BODIPY 2 b in (a) chloro­form, DMSO and toluene; (b) chloro­form over 45 min; (c) DMSO over 45 min; (d) toluene over 60 min.

On the other hand, time-dependent spectroscopic changes, in emission intensity, shift of maximal emission wavelength, or absorbance, have been observed for compounds that undergo self-assembly in solution (Gassensmith et al., 2007  ; Miyatake et al., 2005  ). Taken together, these observations suggest that BODIPY 2b shows a tendency to form assembled structures in chloro­form, not as significantly in DMSO, and particularly not in toluene.

It can be seen from the crystal structure of BODIPY 2b that the mol­ecules are linked along the BODIPY plane by inter­actions between one of the amino H atoms and the BODIPY π ring (N—H(...)π ring; Table 1  and Fig. 4  ).

Figure 4
Part of the crystal structure of 2b, with weak C—H(...)π inter­actions shown as dashed lines.
Table 1
Hydrogen-bond geometry (Å, °)

It is conceivable that in solutions such as in di­chloro­methane, chloro­form and di­bromo­ethane, compound 2b could maintain similar inter­molecular assemblies. As a consequence of the reduced mobility of the BODIPY mol­ecules in these assembled structures, the alkyl signals are broadened to the extent that they become invisible in the NMR spectra (Celis et al., 2013  ; Brand et al., 2008  ; Chen et al., 2015  ). Motion of the phenyl rings, however, is not affected in the assembly, and thus the phenyl aromatic protons are visible in these solvents. In polar solvents such as DMSO and methanol, it is possible that solvation of the BODIPY NH2 group abolishes the ability for such assemblies to occur. On the other hand, in toluene, strong inter­actions of the aromatic benzene ring with the BODIPY co-plane could also diminish the assemblies. The emission profiles of BODIPY 2b in DMSO, chloro­form and toluene also corroborate this model.

Structural commentary  

The mol­ecular structure of 2b shown in Fig. 1  displays a typical BODIPY structure (Tram et al., 2009  ). The central six-membered ring has a flattened sofa conformation with atom N1 deviating by 0.142 (4) Å from the mean plane of the other five atoms (N2/C4/C5/C6/N1), which has an r.m.s. deviation of 0.015 Å. The dihedral angle between the two essentailly planar outer five-membered rings (N1/C1–C4 and N2/C6–C9) is 8.0 (2)°. The two B—N bond lengths are the same within experimental error [1.594 (4) and 1.579 (4) Å], confirming the delocalized nature of the BODIPY core. The two phenyl rings form dihedral angles of 78.8 (1) (C17–C22) and 80.8 (1)° (C23–C28) with the approximate plane of the 12 atoms of the BODIPY core (B1/N1/N2/C1–C9), which has an r.m.s. deviation of 0.067 Å. The dihedral angle between the two phenyl rings is 48.6 (2)°. Methyl atoms C12 and C15, belonging to the ethyl substituents, deviate by −1.326 (4) and 1.348 (3) Å, respectively, from the mean plane of the 12 atoms of the BODIPY core. There is a weak intra­molecular N3—H1N(...)π inter­action involving the amino group and the C17–C22 phenyl ring (Table 1  ).

Supra­molecular features  

In the crystal, mol­ecules are linked via weak N—H(...)π inter­actions (Table 1  ), forming chains along [010] (Fig. 4  ).

Spectroscopy and experimental  

Bruker Avance 300 and 600 Digital NMR spectrometers with a 14.1 and 7.05 Tesla Ultrashield magnet, respectively, were used to obtain 1H and 11B NMR spectra. 1H NMR spectra were measured at 300 or 600 MHz, and 11B at 96 MHz. Chemical shifts and coupling constants (J values) are given in ppm (δ) and Hz, respectively. Deuterated solvents were purchased from C/D/N Isotopes Inc. Fluorescence spectroscopy was recorded using a QuantaMaster model QM-2001-4 cuvette-based L-format scanning spectro­fluoro­meter from Photon Technology Inter­national (PTI), inter­faced with FeliX32 software. UV–Vis spectra were obtained using a Thermospectronic/Unicam UV/Vis spectrometer configured to the Vision32 software.

Anhydrous di­chloro­methane, tri­ethyl­amine and toluene were generated by first heating under reflux in the presence of phospho­rus pentoxide, calcium hydride and sodium metal, respectively, followed by distillation under an atmosphere of nitro­gen. All other chemicals and reagents were purchased from Sigma–Aldrich or TCI without further purification prior to use.

Synthesis and crystallization  

For the preparation of 2b, a solution of sodium nitrite (80 mg, 1.2 mmol) in water (1.0 ml) was added dropwise to another solution of 3-ethyl-2,4-di­methyl­pyrrole (0.25 ml, 1.85 mmol) in acetic acid (7.5 ml) and acetic anhydride (7.5 ml). The mixture was then heated at 373 K for 4 h. The solvents were removed under reduced pressure. The resulting products were diluted with di­chloro­methane (20 ml) and washed with a saturated aqueous sodium bicarbonate solution (2 × 15 ml). The organic phase was dried (MgSO4) and evaporated to dryness under reduced pressure. The residue was co-evaporated with dry toluene (10 ml) and then redissolved in dry di­chloro­methane (10 ml), followed by addition of dry tri­ethyl­amine (1.0 ml, 7.1 mmol). After stirring for 30 min, boron–di­phenyl­bromide (Noth & Vahrenkamp, 1968  ) (1.5 ml, 8.2 mmol) was added. Stirring was continued for 20 h and the products were washed with water (3 × 30 ml), dried (MgSO4) and evaporated under reduced pressure. The residue was purified by column chromatography on silica gel. The appropriate fractions, eluted with di­chloro­methane–hexane (1:9 v/v), were pooled and concentrated under reduced pressure to give the title compound as an orange solid (yield 18 mg, 4%). Single crystals were obtained by slow evaporation of the corresponding solution in hexane. δH[DMSO-d 6]: 7.19–7.64 (br, 10H), 6.89 (s, 1H), 5.94 (br, 2H), 2.55 (q, 2H, J = 7.5), 2.27 (q, 2H, J = 7.5 Hz), 2.13 (s, 3H), 1.83 (s, 3H), 1.50 (s, 3H), 1.09 (t, 2H, J = 7.5 Hz), 0.93 (t, 2H, J = 7.5 Hz). δB[DMSO-d 6]: 0.66 (s).

Refinement  

Crystal data, data collection and structure refinement details are summarized in Table 2  . H atoms bonded to C atoms were included in calculated positions, with C—H = 0.95–0.99 Å, and were allowed to refine in a riding-motion approximation, with U iso(H) = 1.2U eq(C) or 1.5U eq(Cmeth­yl). The amino H atoms were refined independently with isotropic displacement parameters.

Table 2
Experimental details

Supplementary Material

Crystal structure: contains datablock(s) I. DOI: 10.1107/S2056989017002213/sj5520sup1.cif

Structure factors: contains datablock(s) I. DOI: 10.1107/S2056989017002213/sj5520Isup2.hkl

CCDC reference: 1531986

Additional supporting information: crystallographic information; 3D view; checkCIF report

Acknowledgments

This work was supported by the Natural Sciences and Engineering Research Council of Canada.

supplementary crystallographic information

Crystal data

C28H32BN3F(000) = 452
Mr = 421.37Dx = 1.193 Mg m3
Monoclinic, P21Mo Kα radiation, λ = 0.71073 Å
a = 9.4938 (7) ÅCell parameters from 4278 reflections
b = 11.5325 (8) Åθ = 2.4–27.5°
c = 11.3739 (9) ŵ = 0.07 mm1
β = 109.557 (2)°T = 147 K
V = 1173.45 (15) Å3Plate, red
Z = 20.35 × 0.27 × 0.07 mm

Data collection

Bruker Kappa APEX DUO CCD diffractometer4054 reflections with I > 2σ(I)
Radiation source: sealed tube with Bruker Triumph monochromatorRint = 0.040
[var phi] and ω scansθmax = 27.5°, θmin = 1.9°
Absorption correction: multi-scan (SADABS; Bruker, 2014)h = −12→12
Tmin = 0.701, Tmax = 0.746k = −14→11
10457 measured reflectionsl = −14→14
5032 independent reflections

Refinement

Refinement on F2Hydrogen site location: mixed
Least-squares matrix: fullH atoms treated by a mixture of independent and constrained refinement
R[F2 > 2σ(F2)] = 0.046w = 1/[σ2(Fo2) + (0.0464P)2 + 0.0459P] where P = (Fo2 + 2Fc2)/3
wR(F2) = 0.104(Δ/σ)max < 0.001
S = 1.03Δρmax = 0.19 e Å3
5032 reflectionsΔρmin = −0.19 e Å3
302 parametersAbsolute structure: Flack x determined using 1500 quotients [(I+)-(I-)]/[(I+)+(I-)] (Parsons et al, 2013)
1 restraintAbsolute structure parameter: −1.3 (10)

Special details

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2)

xyzUiso*/Ueq
N10.6209 (2)0.4011 (2)0.47877 (19)0.0171 (5)
N20.7753 (2)0.51637 (19)0.66391 (19)0.0174 (5)
N30.4280 (3)0.2624 (2)0.4350 (3)0.0291 (6)
C10.5218 (3)0.3302 (3)0.4010 (3)0.0204 (6)
C20.5273 (3)0.3383 (3)0.2759 (3)0.0223 (6)
C30.6299 (3)0.4212 (3)0.2787 (2)0.0191 (6)
C40.6900 (3)0.4631 (2)0.4057 (2)0.0174 (6)
C50.7876 (3)0.5506 (2)0.4559 (2)0.0187 (6)
H5A0.82980.59270.40410.022*
C60.8277 (3)0.5803 (2)0.5833 (2)0.0172 (6)
C70.9196 (3)0.6704 (2)0.6497 (3)0.0192 (6)
C80.9259 (3)0.6587 (2)0.7743 (3)0.0208 (6)
C90.8385 (3)0.5641 (3)0.7804 (2)0.0202 (6)
C100.4334 (4)0.2669 (3)0.1690 (3)0.0348 (8)
H10A0.45450.28850.09330.052*
H10B0.32750.28050.15660.052*
H10C0.45660.18460.18710.052*
C110.6694 (3)0.4692 (3)0.1714 (3)0.0243 (7)
H11A0.65590.40810.10750.029*
H11B0.77600.49240.20090.029*
C120.5734 (4)0.5736 (3)0.1125 (3)0.0434 (9)
H12A0.60300.60280.04330.065*
H12B0.58730.63480.17530.065*
H12C0.46800.55060.08110.065*
C130.9925 (3)0.7628 (3)0.5969 (3)0.0279 (7)
H13A1.09910.76720.64620.042*
H13B0.94510.83770.59980.042*
H13C0.98100.74390.51020.042*
C141.0172 (3)0.7322 (3)0.8821 (3)0.0260 (7)
H14A0.96880.73310.94690.031*
H14B1.01930.81290.85300.031*
C151.1776 (3)0.6883 (3)0.9400 (3)0.0365 (8)
H15A1.23280.73941.00890.055*
H15B1.22650.68800.87650.055*
H15C1.17650.60940.97160.055*
C160.8189 (3)0.5127 (3)0.8948 (3)0.0263 (7)
H16A0.71330.51610.88760.039*
H16B0.87870.55650.96840.039*
H16C0.85210.43170.90320.039*
C170.5151 (3)0.4325 (2)0.6603 (2)0.0182 (6)
C180.4069 (3)0.5069 (3)0.5835 (3)0.0269 (7)
H18A0.42450.54100.51360.032*
C190.2748 (3)0.5331 (3)0.6051 (3)0.0355 (8)
H19A0.20360.58350.55020.043*
C200.2475 (3)0.4855 (3)0.7068 (3)0.0347 (8)
H20A0.15790.50360.72280.042*
C210.3512 (3)0.4115 (3)0.7851 (3)0.0337 (8)
H21A0.33300.37830.85510.040*
C220.4828 (3)0.3855 (3)0.7615 (3)0.0261 (7)
H22A0.55280.33410.81610.031*
C230.7586 (3)0.2907 (2)0.6849 (2)0.0177 (6)
C240.9149 (3)0.2865 (3)0.7172 (3)0.0239 (6)
H24A0.96670.35500.70960.029*
C250.9962 (3)0.1863 (3)0.7597 (3)0.0301 (7)
H25A1.10180.18700.78050.036*
C260.9244 (4)0.0857 (3)0.7719 (3)0.0295 (7)
H26A0.98010.01690.80110.035*
C270.7705 (4)0.0853 (3)0.7414 (3)0.0276 (7)
H27A0.72010.01600.74910.033*
C280.6900 (3)0.1866 (3)0.6996 (3)0.0238 (6)
H28A0.58460.18530.68030.029*
B10.6672 (3)0.4083 (3)0.6269 (3)0.0181 (6)
H2N0.359 (4)0.227 (3)0.376 (3)0.035 (10)*
H1N0.417 (4)0.268 (3)0.508 (4)0.052 (12)*

Atomic displacement parameters (Å2)

U11U22U33U12U13U23
N10.0158 (11)0.0172 (13)0.0187 (11)−0.0024 (9)0.0062 (9)0.0003 (9)
N20.0170 (11)0.0171 (13)0.0173 (11)0.0007 (9)0.0046 (9)0.0019 (9)
N30.0315 (15)0.0320 (17)0.0225 (14)−0.0164 (12)0.0072 (12)−0.0018 (12)
C10.0202 (14)0.0194 (17)0.0202 (14)−0.0043 (11)0.0048 (11)−0.0022 (11)
C20.0221 (14)0.0232 (18)0.0201 (14)−0.0028 (12)0.0053 (11)−0.0008 (12)
C30.0174 (13)0.0207 (17)0.0200 (13)0.0019 (11)0.0071 (11)−0.0007 (11)
C40.0176 (13)0.0166 (17)0.0193 (14)0.0011 (11)0.0079 (11)0.0030 (10)
C50.0168 (13)0.0206 (16)0.0203 (13)0.0014 (11)0.0084 (11)0.0034 (11)
C60.0145 (13)0.0170 (16)0.0203 (13)0.0004 (10)0.0057 (10)0.0016 (11)
C70.0157 (13)0.0168 (17)0.0240 (14)0.0000 (11)0.0052 (11)−0.0002 (11)
C80.0189 (13)0.0185 (18)0.0232 (15)0.0019 (11)0.0046 (11)−0.0023 (12)
C90.0168 (13)0.0221 (17)0.0195 (14)0.0029 (11)0.0031 (11)−0.0008 (11)
C100.042 (2)0.034 (2)0.0282 (16)−0.0144 (15)0.0110 (14)−0.0074 (15)
C110.0289 (15)0.0261 (18)0.0208 (15)−0.0028 (13)0.0120 (12)−0.0013 (11)
C120.055 (2)0.044 (2)0.0372 (19)0.0168 (17)0.0241 (17)0.0187 (17)
C130.0289 (16)0.0236 (18)0.0307 (16)−0.0063 (13)0.0095 (13)−0.0004 (13)
C140.0299 (17)0.0221 (18)0.0247 (15)−0.0037 (12)0.0072 (13)−0.0064 (12)
C150.0292 (17)0.040 (2)0.0307 (18)−0.0052 (15)−0.0023 (14)−0.0083 (14)
C160.0303 (15)0.0278 (18)0.0209 (15)−0.0040 (13)0.0086 (12)−0.0006 (12)
C170.0170 (13)0.0158 (16)0.0217 (14)−0.0020 (10)0.0062 (10)−0.0024 (11)
C180.0237 (15)0.0267 (18)0.0306 (16)0.0032 (12)0.0094 (12)0.0051 (13)
C190.0257 (16)0.035 (2)0.0425 (19)0.0076 (14)0.0074 (14)0.0016 (15)
C200.0220 (15)0.035 (2)0.052 (2)−0.0011 (13)0.0191 (15)−0.0099 (15)
C210.0334 (18)0.040 (2)0.0364 (18)−0.0022 (15)0.0229 (15)0.0010 (15)
C220.0236 (15)0.0269 (19)0.0281 (16)0.0017 (12)0.0090 (12)0.0027 (12)
C230.0215 (14)0.0186 (16)0.0144 (13)−0.0013 (11)0.0079 (11)−0.0025 (10)
C240.0230 (15)0.0221 (17)0.0279 (15)−0.0006 (12)0.0103 (12)−0.0002 (12)
C250.0235 (15)0.0296 (19)0.0366 (18)0.0065 (13)0.0094 (13)−0.0004 (14)
C260.0336 (18)0.0218 (19)0.0304 (17)0.0104 (13)0.0071 (13)0.0037 (13)
C270.0345 (17)0.0174 (18)0.0305 (16)0.0002 (12)0.0103 (13)0.0019 (12)
C280.0206 (14)0.0246 (18)0.0249 (15)−0.0028 (12)0.0057 (12)0.0019 (12)
B10.0190 (15)0.0184 (18)0.0170 (15)−0.0018 (12)0.0060 (12)0.0017 (12)

Geometric parameters (Å, º)

N1—C11.334 (3)C13—H13C0.9800
N1—C41.413 (3)C14—C151.529 (4)
N1—B11.594 (4)C14—H14A0.9900
N2—C91.374 (3)C14—H14B0.9900
N2—C61.392 (3)C15—H15A0.9800
N2—B11.579 (4)C15—H15B0.9800
N3—C11.335 (4)C15—H15C0.9800
N3—H2N0.87 (4)C16—H16A0.9800
N3—H1N0.87 (4)C16—H16B0.9800
C1—C21.445 (4)C16—H16C0.9800
C2—C31.358 (4)C17—C221.396 (4)
C2—C101.492 (4)C17—C181.398 (4)
C3—C41.446 (4)C17—B11.635 (4)
C3—C111.498 (4)C18—C191.389 (4)
C4—C51.360 (4)C18—H18A0.9500
C5—C61.411 (4)C19—C201.382 (5)
C5—H5A0.9500C19—H19A0.9500
C6—C71.404 (4)C20—C211.379 (5)
C7—C81.405 (4)C20—H20A0.9500
C7—C131.501 (4)C21—C221.396 (4)
C8—C91.386 (4)C21—H21A0.9500
C8—C141.505 (4)C22—H22A0.9500
C9—C161.496 (4)C23—C281.403 (4)
C10—H10A0.9800C23—C241.405 (4)
C10—H10B0.9800C23—B11.626 (4)
C10—H10C0.9800C24—C251.383 (4)
C11—C121.523 (4)C24—H24A0.9500
C11—H11A0.9900C25—C261.377 (5)
C11—H11B0.9900C25—H25A0.9500
C12—H12A0.9800C26—C271.384 (4)
C12—H12B0.9800C26—H26A0.9500
C12—H12C0.9800C27—C281.391 (4)
C13—H13A0.9800C27—H27A0.9500
C13—H13B0.9800C28—H28A0.9500
C1—N1—C4106.5 (2)C8—C14—C15112.5 (3)
C1—N1—B1128.0 (2)C8—C14—H14A109.1
C4—N1—B1125.2 (2)C15—C14—H14A109.1
C9—N2—C6106.6 (2)C8—C14—H14B109.1
C9—N2—B1127.5 (2)C15—C14—H14B109.1
C6—N2—B1125.9 (2)H14A—C14—H14B107.8
C1—N3—H2N117 (2)C14—C15—H15A109.5
C1—N3—H1N122 (3)C14—C15—H15B109.5
H2N—N3—H1N118 (3)H15A—C15—H15B109.5
N1—C1—N3123.9 (3)C14—C15—H15C109.5
N1—C1—C2111.3 (2)H15A—C15—H15C109.5
N3—C1—C2124.8 (3)H15B—C15—H15C109.5
C3—C2—C1106.5 (2)C9—C16—H16A109.5
C3—C2—C10129.6 (3)C9—C16—H16B109.5
C1—C2—C10123.9 (3)H16A—C16—H16B109.5
C2—C3—C4107.4 (2)C9—C16—H16C109.5
C2—C3—C11127.9 (3)H16A—C16—H16C109.5
C4—C3—C11124.6 (3)H16B—C16—H16C109.5
C5—C4—N1120.9 (2)C22—C17—C18115.8 (3)
C5—C4—C3130.7 (2)C22—C17—B1125.5 (2)
N1—C4—C3108.3 (2)C18—C17—B1118.7 (2)
C4—C5—C6121.6 (3)C19—C18—C17122.7 (3)
C4—C5—H5A119.2C19—C18—H18A118.6
C6—C5—H5A119.2C17—C18—H18A118.6
N2—C6—C7109.5 (2)C20—C19—C18119.7 (3)
N2—C6—C5120.9 (2)C20—C19—H19A120.2
C7—C6—C5129.6 (3)C18—C19—H19A120.2
C6—C7—C8106.2 (2)C21—C20—C19119.6 (3)
C6—C7—C13126.7 (2)C21—C20—H20A120.2
C8—C7—C13127.1 (2)C19—C20—H20A120.2
C9—C8—C7107.6 (2)C20—C21—C22120.0 (3)
C9—C8—C14126.4 (3)C20—C21—H21A120.0
C7—C8—C14125.9 (3)C22—C21—H21A120.0
N2—C9—C8110.0 (2)C17—C22—C21122.2 (3)
N2—C9—C16122.6 (3)C17—C22—H22A118.9
C8—C9—C16127.3 (2)C21—C22—H22A118.9
C2—C10—H10A109.5C28—C23—C24115.5 (3)
C2—C10—H10B109.5C28—C23—B1123.8 (2)
H10A—C10—H10B109.5C24—C23—B1120.6 (2)
C2—C10—H10C109.5C25—C24—C23122.5 (3)
H10A—C10—H10C109.5C25—C24—H24A118.7
H10B—C10—H10C109.5C23—C24—H24A118.7
C3—C11—C12112.0 (3)C26—C25—C24120.1 (3)
C3—C11—H11A109.2C26—C25—H25A120.0
C12—C11—H11A109.2C24—C25—H25A120.0
C3—C11—H11B109.2C25—C26—C27119.7 (3)
C12—C11—H11B109.2C25—C26—H26A120.2
H11A—C11—H11B107.9C27—C26—H26A120.2
C11—C12—H12A109.5C26—C27—C28119.7 (3)
C11—C12—H12B109.5C26—C27—H27A120.1
H12A—C12—H12B109.5C28—C27—H27A120.1
C11—C12—H12C109.5C27—C28—C23122.4 (3)
H12A—C12—H12C109.5C27—C28—H28A118.8
H12B—C12—H12C109.5C23—C28—H28A118.8
C7—C13—H13A109.5N2—B1—N1104.3 (2)
C7—C13—H13B109.5N2—B1—C23109.8 (2)
H13A—C13—H13B109.5N1—B1—C23107.8 (2)
C7—C13—H13C109.5N2—B1—C17110.4 (2)
H13A—C13—H13C109.5N1—B1—C17107.6 (2)
H13B—C13—H13C109.5C23—B1—C17116.1 (2)
C4—N1—C1—N3−175.8 (3)C2—C3—C11—C1289.8 (4)
B1—N1—C1—N39.8 (5)C4—C3—C11—C12−85.5 (4)
C4—N1—C1—C23.0 (3)C9—C8—C14—C1591.3 (4)
B1—N1—C1—C2−171.4 (2)C7—C8—C14—C15−85.5 (4)
N1—C1—C2—C3−2.6 (3)C22—C17—C18—C19−0.2 (5)
N3—C1—C2—C3176.2 (3)B1—C17—C18—C19−179.6 (3)
N1—C1—C2—C10177.9 (3)C17—C18—C19—C200.6 (5)
N3—C1—C2—C10−3.3 (5)C18—C19—C20—C21−0.6 (5)
C1—C2—C3—C41.0 (3)C19—C20—C21—C220.2 (5)
C10—C2—C3—C4−179.5 (3)C18—C17—C22—C21−0.3 (4)
C1—C2—C3—C11−175.0 (3)B1—C17—C22—C21179.0 (3)
C10—C2—C3—C114.5 (5)C20—C21—C22—C170.3 (5)
C1—N1—C4—C5173.9 (3)C28—C23—C24—C250.6 (4)
B1—N1—C4—C5−11.4 (4)B1—C23—C24—C25−176.0 (3)
C1—N1—C4—C3−2.3 (3)C23—C24—C25—C26−0.1 (5)
B1—N1—C4—C3172.3 (2)C24—C25—C26—C270.0 (5)
C2—C3—C4—C5−175.0 (3)C25—C26—C27—C28−0.4 (5)
C11—C3—C4—C51.1 (5)C26—C27—C28—C231.0 (4)
C2—C3—C4—N10.8 (3)C24—C23—C28—C27−1.0 (4)
C11—C3—C4—N1176.9 (2)B1—C23—C28—C27175.4 (3)
N1—C4—C5—C62.2 (4)C9—N2—B1—N1175.5 (2)
C3—C4—C5—C6177.5 (3)C6—N2—B1—N1−6.1 (3)
C9—N2—C6—C7−2.0 (3)C9—N2—B1—C23−69.2 (3)
B1—N2—C6—C7179.3 (2)C6—N2—B1—C23109.2 (3)
C9—N2—C6—C5177.7 (2)C9—N2—B1—C1760.1 (3)
B1—N2—C6—C5−1.0 (4)C6—N2—B1—C17−121.5 (3)
C4—C5—C6—N23.9 (4)C1—N1—B1—N2−174.3 (3)
C4—C5—C6—C7−176.5 (3)C4—N1—B1—N212.3 (3)
N2—C6—C7—C81.5 (3)C1—N1—B1—C2369.0 (3)
C5—C6—C7—C8−178.1 (3)C4—N1—B1—C23−104.5 (3)
N2—C6—C7—C13−176.8 (3)C1—N1—B1—C17−57.0 (4)
C5—C6—C7—C133.5 (5)C4—N1—B1—C17129.6 (3)
C6—C7—C8—C9−0.4 (3)C28—C23—B1—N2161.5 (2)
C13—C7—C8—C9177.9 (3)C24—C23—B1—N2−22.2 (3)
C6—C7—C8—C14176.9 (3)C28—C23—B1—N1−85.4 (3)
C13—C7—C8—C14−4.8 (4)C24—C23—B1—N190.9 (3)
C6—N2—C9—C81.8 (3)C28—C23—B1—C1735.3 (4)
B1—N2—C9—C8−179.6 (2)C24—C23—B1—C17−148.4 (2)
C6—N2—C9—C16−174.8 (3)C22—C17—B1—N2−104.1 (3)
B1—N2—C9—C163.8 (4)C18—C17—B1—N275.2 (3)
C7—C8—C9—N2−0.9 (3)C22—C17—B1—N1142.6 (3)
C14—C8—C9—N2−178.1 (3)C18—C17—B1—N1−38.1 (3)
C7—C8—C9—C16175.5 (3)C22—C17—B1—C2321.8 (4)
C14—C8—C9—C16−1.7 (5)C18—C17—B1—C23−158.9 (3)

Hydrogen-bond geometry (Å, º)

Cg1 and Cg2 are the centroids of the C17-C22 and N2/C6-C9 rings, respectively.

D—H···AD—HH···AD···AD—H···A
N3—H1N···Cg10.87 (4)3.07 (3)3.772 (2)139 (2)
N3—H2N···Cg2i0.87 (4)2.44 (3)3.223 (2)150 (2)

Symmetry code: (i) −x+1, y−1/2, −z+1.

References

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Articles from Acta Crystallographica Section E: Crystallographic Communications are provided here courtesy of International Union of Crystallography