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ACG Case Rep J. 2017; 4: e22.
Published online 2017 February 15. doi:  10.14309/crj.2017.22
PMCID: PMC5340654

Primary Hepatic Amyloidosis Presenting as Acute-on-Chronic Liver Failure


Systemic amyloidosis of amyloid light chain associated protein (AL), also called primary amyloidosis, frequently involves the liver, but rarely causes clinically apparent liver disease. The more common presentation is with acute renal failure. Hepatomegaly and mild elevation of alkaline phosphatase are the most common clinical and biochemical findings, respectively. We report a case of systemic amyloidosis of AL that clinically presented as acute-on-chronic liver failure and resulted in a fatal clinical course in a 56-year-old man.

Articles from ACG Case Reports Journal are provided here courtesy of American College of Gastroenterology