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Patient Prefer Adherence. 2017; 11: 423–429.
Published online 2017 March 2. doi:  10.2147/PPA.S119180
PMCID: PMC5338969

Quality of life in overweight (obese) and normal-weight women with polycystic ovary syndrome



Polycystic ovary syndrome (PCOS) is characterized by phenotypic heterogeneity and has a wide variety of consequences. Approximately half of women with PCOS are overweight or obese, and their obesity may be a contributing factor to PCOS pathogenesis through different mechanisms. The aim of this study was to evaluate if PCOS alone affects the patients’ quality of life and to what extent obesity contributes to worsen this disease.


To evaluate the impact of PCOS on health-related quality-of-life (HRQoL), 100 Mediterranean women with PCOS (group A), 50 with a body mass index (BMI) >25 kg/m2 (group A1) and 50 with BMI <25 kg/m2 (group A2), were recruited. They were evaluated with a specific combination of standardized psychometric questionnaires: the Symptom Checklist-90 Revised, the 36-Item Short-Form Health Survey, and the Polycystic Ovary Syndrome Questionnaire. The patients were compared with a normal-weight healthy control group of 40 subjects (group B). Another control group of 40 obese healthy women (group C) was used to make a comparison with PCOS obese patients (A1).


Our results showed a considerable worsening of HRQoL in PCOS patients (A) compared with controls (B). In addition, patients with PCOS and BMI >25 (A1) showed a significant and more marked reduction in scores, suggesting a lower quality of life, compared with controls (B) and with normal-weight PCOS patients (A2).


PCOS is a complex disease that alone determines a deterioration of HRQoL. The innovative use of these psychometric questionnaires in this study, in particular the PCOS questionnaire, has highlighted that obesity has a negative effect on HRQoL. It follows that a weight decrease is associated to phenotypic spectrum improvement and relative decrement in psychological distress.

Keywords: polycystic ovary syndrome, obesity, normal-weight, health-related quality-of-life, psychological disturbances


Polycystic ovary syndrome (PCOS) is a common, endocrine-metabolic disorder affecting premenopausal women and has a prevalence ranging from 5% to 10% among Mediterranean women,1 but its pathophysiology has not yet been fully understood.2 PCOS is characterized by oligo-anovulatory menstrual cycles, larger and micropoly-cystic ovaries, and a variable degree of hyperandrogenism,3 and it is usually associated with metabolic disorders (insulin resistance, hyperinsulinemia, obesity, dyslipidemia, diabetes mellitus type 2, etc) and higher cardiovascular risk.4,5

Approximately half of women with PCOS are overweight or obese.615 The pathogenetic role of obesity can affect different mechanisms, of which the most important is the hyperinsulinemic state given that insulin can stimulate ovary androgen secretion and play an important role in the metabolism of androgens and their transport to peripheral tissues.16,17 Abdominal fat distribution in obese PCOS women can increase the degree of hyperandrogenism and its related clinical symptoms and signs.18,19 Though the role of obesity is generally acknowledged, relatively little attention has been focused on its real impact on the patients’ quality of life.20 This condition can weigh heavily against the carrying out of daily work and social activities, thus causing a significant reduction in health-related quality-of-life (HRQoL) in young patients.2123 HRQoL represents a multidimensional index of physical, psychological, and social aspects associated with a specific pathology. The aim of this study was to evaluate how PCOS alone affects the quality of life and to assess to what extent obesity negatively influences it. In other words, this study evaluated the impact that the specific association between PCOS and obesity has on HRQoL.

Materials and methods

All recruited patients met the Rotterdam criteria of European Society of Human Reproduction and Embryology, Ameri-can Society for Reproductive Medicine-sponsored PCOS Consensus Workshop Group (2003).24 Participants were provided with both written and oral information regarding the study protocol and were informed that they were free to withdraw from the study at any time. All subjects gave their written informed consent before participation. All procedures conformed to the directives of the Declaration of Helsinki. This study has been approved by the Azienda Universitaria Policlinico of the Second University of Naples. We recruited 100 Mediterranean women with PCOS aged 17.2–29 years divided into the following groups: (mean age: 23.1±5.9 years) (group A) 50 with a body mass index (BMI) >25 kg/m2 (group A1; aged 22.8±5.6 years; BMI: 31.6±5.8 kg/m2) and 50 with a BMI <25 kg/m2 (group A2; aged 23.3±6.1 years; BMI: 22.3±1.6 kg/m2). The patients were compared with a healthy normal-weight control group of 40 patients ranging from 16.4 to 31.8 years, who were age-matched and had a similar socioeconomic background (group B; aged 24.1±7.7 years; BMI: 22.0±2.1 kg/m2). Another control group of 40 obese healthy women aged from 17.1 to 29.5 years (group C; aged 23.3±6.2 years; BMI: 28.4±2.2 kg/m2) was used to make a comparison with PCOS obese patients (A1) to establish to what extent the worsening of quality of life can be ascribed to PCOS alone and to what, instead, it can be ascribed to an elevated BMI. These patients were administered the following questionnaires with the aim of evaluating the impact of the clinical spectrum of PCOS on HRQoL:25

Symptom Checklist 90-Revised (SCL-90-R)

It includes 90 items grouped into 10 main domains: Somatization (SOM), Obsessive–Compulsive (O–C), Interpersonal Sensitivity (INT), Depression (DEP), Anxiety (ANX), Aggression (HOS), Phobia (PHOB), Paranoid Ideation (PAR), Psychoticism (PSY), and Sleep Disorders (SLEEP). To each question of a single domain can be attributed a score from 0 (not at all) to 4 (very much). Higher scores are indicative of worse conditions.

36-Item Short-Form Health Survey (SF 36)

It is a generic questionnaire used to evaluate HRQoL, the activity level, and the feeling of individual well-being. It consists of 36 items organized into eight domains: Physical Function (AF), Physical Role Function (RF), Bodily Pain (BP), General Health (GH), Vitality (VT), Social Function (SF), Emotional Role Function (RE), and Mental Health (SM) as well as an item on the change of General Health. The scores of each domain have been converted into a scale from 0 to 100. Lower scores are indicative of worse conditions.

Polycystic Ovary Syndrome Questionnaire (PCOSQ)

A specific questionnaire used to outline the impact of the symptoms and signs of PCOS on HRQoL and whose proprieties were previously validated.26 PCOSQ contains 26 items organized into five domains: Emotions (EMOT), Hirsutism (HIRS), Body Weight (BW), Infertility (INF), and Menstrual Disorders (MD). In addition, for the present study, an “acne” domain with four different items useful to reinforce the usefulness of PCOSQ was also included.27 A score from 1 (always) to 7 (never) has been attributed to each question. Lower scores are indicative of more serious conditions. An arbitrary threshold of three was fixed, and the patient was considered “seriously” affected in the domains in which they scored above 3.

Pearson’s coefficient was used to interpret the correlation between BMI and each of the test domains. The Student’s t-test was used to verify the significance of the differences in the main score for each domain between PCOS and healthy group (A vs B), PCOS obese and PCOS lean patients (A1 vs A2), and, finally, PCOS obese patients and healthy obese controls (A1 vs C). The level of significance was fixed, in all the cases, at 0.05.


SCL-90-R revealed significantly elevated scores in PCOS patients (A) compared with controls (B) in three symptomatic dimensions: O–C (A: 0.7±0.5; B: 0.3±0.3; P<0.001), DEP (A: 0.9±0.4; B: 0.7±0.5; P=0.03), and ANX (A: 0.7±0.4; B: 0.4±0.3; P=0.003) (Figure 1). In addition, there was a positive correlation between BMI and 1) SOM (P<0.001), confirmed also by Student’s t-test (A1: 0.8±0.5; A2: 0.6±0.3; P=0.03); 2) INT (P<0.001), confirmed also by Student’s t-test (A1: 0.7±0.3; A2: 0.6±0.3; P=0.02); and 3) PAR (P<0.001), confirmed also by Student’s t-test (A1: 0.8±0.4; A2: 0.5±0.1; P<0.001) (Figure 2). Finally, the comparison between healthy obese women (C) and PCOS obese patients (A1) revealed higher scores in the latter in the following domains: SOM (A1: 0.8±0.5; C: 0.6±0.3; P<0.05), O–C (A1: 0.8±0.5; C: 0.4±0,1; P<0.001), ANX (A1: 0.7±0.5; C: 0.5±0.1; P=0.005), HOS (A1: 0.6±0.1; C: 0.5±0.1; P<0.001), PHOB (A1: 0.3±0.1; C: 0.2±0.2; P=0.05), and INT (A1: 0.6±0.1; C: 0.5±0.2; P<0.001).

Figure 1
SCL-90-R in PCOS patients (A) and healthy normal-weight controls (B).
Figure 2
SCL-90-R in PCOS obese patients (A1), PCOS normal-weight patients (A2), normal-weight healthy controls (B), and healthy obese controls (C).

With regard to SF36, it was shown that PCOS patients (A), compared with healthy controls (B), had decreased scores, indicating lower quality of life, in the domains of VT (A: 53.4±12.1; B: 65.2±2.5; P<0.001), RE (A: 52.3±27.6; B: 75.6±6.1; P<0.001), SM (A: 47.5±13.7; B: 68.0±3.9; P<0.001), SF (A: 57.1±23.8; B: 77.8±8.0; P<0.001), and AF (A: 90.1±6.2; B: 97.3±1.2; P<0.001). No significant difference was found in the domains of RF (A: 80.1±16.3; B: 86.9±5.5; P=0.07), GH (A: 72.6±6.5; B: 74.9±1.6; P=0.11), and BP (A: 94.1±6.2; B: 95.0±7.4; P=0.802) (Figure 3). In addition, there was a positive correlation between BMI and 1) AP (P<0.001), confirmed also by Student’s t-test (A1: 85.9±5.5; A2: 94.2±3.4; P<0.001) and 2) SF (P<0.001), confirmed also by Student’s t-test (A1: 48.5±22.4; A2: 65.8±21.9; P<0.001) (Figure 4). Finally, the comparison between healthy obese women (C) and PCOS obese patients (A1) revealed higher scores in the latter group in the following domains: AF (A1: 85.9±5.5; C: 88.8±3.3; P<0.001), VT (A1: 54.3±10.6; C: 60.0±5.0; P=0.001), RE (A1: 49.3±22.4; C: 63.2±13.1; P<0.0001), and SM (A1: 45.7±12.9; C: 51.7±3.6; P=0.005).

Figure 3
SF-36 in PCOS patients (A) and healthy normal-weight controls (B).
Figure 4
SF-36 in PCOS obese patients (A1), PCOS normal-weight patients (A2), lean normal-weight healthy controls (B), and healthy obese controls (C).

PCOS patients (A), compared with controls (B), had significantly lower scores in PCOSQ in the domains of: EMOT (A: 4.7±1.1; B: 6.7±0.1; P<0.001), HIRS (A: 3.6±1.0; B: 6.2±0.1; P<0.001), BW (A: 3.6±1.2; B: 7.0±0.1; P<0.001), INF (A: 3.7±1.1; B: 6.9±0.2; P<0.001), ACNE (A: 3.7±1.0; B: 5.6±0.3; P<0.001), and MD (A: 3.7±1.0; B: 6.5±0.1; P<0.001) (Figure 5). In addition, there was a positive correlation between BMI and 1) EMOT (P<0.001), confirmed also by Student’s t-test (A1: 4.5±1.1; A2: 4.9±0.9; P<0.001); 2) BW (P<0.001), confirmed also by Student’s t-test (A1: 3.2±1.1; A2: 3.9±1.1; P<0.001); and 3) ACNE (P<0.01), confirmed also by Student’s t-test (A1: 3.4±1.0; A2: 3.9±1.0; P=0.03) (Figure 6). Having set the pathological threshold of the mean score at 3, the most frequently affected domains were BW (22%), Hirs (19%), Emot (18%), Acne (18%), Inf (17%), and MD (17%). Finally, the comparison between healthy obese women (C) and PCOS obese patients (A1) revealed higher scores in the latter group in all the domains of the test: EMOT (A1: 4.5±1.1; C: 4.9±0.9; P<0.05), HIRS (A1: 3.5±1.2; C: 4.2±0.9; P<0.002), BW (A1: 3.2±1.1; C: 4.1±0.9; P<0.0001), INF (A1: 3.7±1.1; C: 4.3±0.8; P=0.003), MD (A1: 3.7±1.0; C: 4.3±1; P=0.001), and ACNE (A1: 3.4±1.0; C: 4.2±0.7; P<0.0001). A positive correlation (P<0.05) was found between BMI and all the domains of SF-36, SCL-90-R, and PCOSQ in the PCOS group (A) and in the control healthy group (B), whereas in the healthy obese group (C) a positive correlation of BMI was revealed only with BP and SM of SF-36, SOM, and PSY of SCL-90-R and none of the PCOSQ domains.

Figure 5
PCOSQ in PCOS patients (A) and healthy normal-weight controls (B).
Figure 6
PCOSQ in PCOS obese patients (A1), PCOS normal-weight patients (A2), normal-weight healthy controls (B), and healthy obese controls (C).


PCOS, characterized by phenotypic heterogeneity and a wide variety of long-term metabolic and cardiovascular complicances,28 is an important cause of severe distress. In fact, hirsutism causes considerable psychological distress confirmed by psychometric evaluation, which reveals marked anxiety and social discomfort;29 infertility causes family tensions and problems at work, while obesity in PCOS women is responsible for a general state of depression and dissatisfaction.30,31 An important study made by Cronin reported that the main problems for the women affected by PCOS were hirsutism (90%), being overweight (84%), menstrual disorders (82%), and difficulties maintaining their body weight (80%).32,33

This study focuses on a Mediterranean population assessed using SCL-90-R, SF-36, and PCOSQ, correlating, for every group, the test scores with BMI. Psychological disturbances, measured by SCL-90-R, strongly influence global well-being. In particular, in PCOS patients (A), the O–C, DEP, and ANX dimensions were considerably affected independently of BMI, as reported in other studies.34,35 Among the main causes of depression and anxiety is probably the dissatisfaction with the body image or womanly identity. Obese patients (A1), moreover, showed significant changes in the dimensions of SOM, INT, and PAR, probably because they showed a more serious phenotypic expression of PCOS and so had difficulty in establishing relations and showed a severe antisocial attitude that could lead to a much greater tendency to somatization. The analysis of SCL-90-R showed that being overweight or obese was not the only determining factor, as demonstrated by the distortion of many domains even in women with normal BMI. HRQoL result worsened also when was evaluated with SF-36. In particular, the domains more significantly affected in the PCOS sample were VT, RE, MH, SF, and AP. This finding suggests that PCOS, regardless of BMI, determines a relevant impairment of psychosocial functions. The domains of SF and AP, however, were significantly more affected in patients with BMI >25 (A1) compared with controls (B). This is in-line with other studies, which also have shown that BMI in the SF-36 is a physical score predictor.36,37 In our study, however, no significant difference was found for the scales of RF, BP, and GH. However, PCOSQ appeared the most sensitive test for the evaluation of HRQoL, and it can provide a lot of information on the causes of psychological distress. PCOSQ identifies weight gain as one of the most important causes of distress in PCOS patients. In particular, PCOS obese patients (A1), compared with nonobese ones (A2), showed a further increase in scores in the domain of BW, ACNE, and EMOT, which emphasizes how the association between PCOS and overweight/obesity can cause a severe worsening of the emotional and the physical domains. The main domains involved were BW (22%) and HIRS (19%), as reported in other studies,38,39 followed by EMOT and ACNE (both 18%), and INF and MD (both 17%). It is important to note that infertility, one of the main malfunctions related to PCOS,4042 proved to be a minor determinant in this study. The reason for this contrasting finding may be the younger age of our sample – a time when maternity is not considered a priority yet. However, the BMI is not the only determinant of worsening of quality of life in PCOS patients, given that from the comparison between PCOS obese women (A1) and obese controls (C), emerged a significant alteration in a lot of the domains: AF, VT, RE, SM (SF-36), SOM, O-C, ANX, HOS, PHOB, SLEEP (SCL-90-R), and in all of the PCOSQ domains. This evidence suggests that PCOS by itself makes worse the quality of life, whereas obesity, when it is present, configures itself as a pejorative element.

Therefore, given that PCOS is an important cause of psychic distress,43 it would be necessary to carry out a psychological screening by making use of HRQoL measurements,4446 besides the routine physical, laboratory, and instrumental examinations, in order to evaluate the fragile psychological balance of these women. We believe that PCOSQ is the most sensitive test to evaluate HRQoL in PCOS patients, as highlighted by the evidence that the differences between the groups studied with PCOSQ were more markedly significant than the ones that emerged from the analysis of the scores obtained from other tests.

The general aim of any treatment is to reach a state of “good health”, which, according to World Health Organization, coincides with the concept of psychophysical well-being and implies a healthy perception of our body and a good relation with ourselves.4750 The restoration of psychophysical well-being is, therefore, the main objective of a proper treatment of PCOS; so this endocrinopathy requires an approach aimed at improving the quality of life and self-perception as well as the symptoms of the disease. Particularly, special care is needed by obese PCOS patients, because their more severe phenotype exposes them to a greater risk of developing serious psychic distress.


In conclusion, the results from our study confirmed the negative impact of PCOS on the patients’ quality of life and particularly highlighted how obesity contributes to its phenotypic spectrum, thus becoming an important pejorative element.


This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.


Author contributions

Annalisa Panico and Giovanni Messina contribute equally to the article. Giovanni Messina and Antonietta Messina are second-degree relatives. Gelsy Arianna Lupoli, Roberta Lupoli, and Giovanni Lupoli are first-degree relatives. Vincenzo Monda and Marcellino Monda are first-degree relatives. All authors contributed toward data analysis, drafting and critically revising the paper and agree to be accountable for all aspects of the work.


The authors reports no conflicts of interests in this work.


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