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Published online 2017 February 19. doi: 10.3390/s17020405

Scheme 2

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The synthesis of probe 1; Reagents and Conditions: (a) NBS, DMF, r.t., 99% yield; (b) (5-formylthiophen-2-yl) boronic acid, Pd(PPh3)4, dioxane, reflux, 3.5 h, 67% yield; (c) malononitrile, piperidine, reflux, 3 h, 70% yield.

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