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Chromatin profiling of genes which are primed during blast cell transformation for subsequent binding of differentiation-inducing transcription factors. Shown here are the previously defined profiles for the mouse type 2 helper (Th2) cytokine gene cluster (A), the Ccl1 locus (B), and the Il12rb2/Il23r locus (C), showing epigenetic profiles defined by Bevington et al. (10), plus other profiles for type 1 helper (Th1) DNase-Seq (89) and TBX21 ChIP-Seq (85), Th2 ATAC-Seq (90) and GATA3 ChIP-Seq (84), and Th17 RORγ ChIP-Seq (86). Note that ATAC-Seq is an alternative method for genome-wide profiling of DNase I hypersensitive sites (DHSs).