|Home | About | Journals | Submit | Contact Us | Français|
Crude mortality rate in intensive care unit varies according to the primary diagnosis of the patients, demographic characteristics of the patients and geographical location of the intensive care units (ICUs) (1-3). Though a decline in the mortality in ICU is evident over the last few decades (4,5), there is still significant gap between the knowledge and practice of the intensive care physicians even in the developed world (6). ICU checklists are expected to increase adherence to the guidelines, reduces medical errors and consequently improves patients’ outcome. A number of studies have evaluated utility of checklist in a particular area such as weaning from mechanical ventilation, catheter related blood stream infection etc. and most of the such studies are of before-after design. Results of the studies on checklist and prompting by the physicians are contradictory. Use of a surgical safety checklist was associated with a reduction in morbidity and mortality in patients with older than 16 years’ age and undergoing non-cardiac surgery (7). Implementation of checklist during ICU round has been associated with improved patients care and implementation of best evidence based practice (8,9). Weiss et al. (10) in 2011 reported a significant reduction in ICU mortality and in-hospital mortality even after baseline risk adjustment from checklist based prompting by a resident physician. In that study, during ICU round, following six areas were considered for prompting if it is missed: weaning from mechanical ventilation, empirical antibiotic therapy, central venous catheters, Foley urinary catheters, and deep vein thrombosis and stress ulcer prophylaxis and prompting continued from first round after ICU admission to ICU discharge.
The strength of this study is that it is a large, well designed trial and baseline characteristics of the patients were comparable after randomization. However, though the authors included practice parameters in the checklist according to guidelines, effects of these practices on mortality is controversial. Such as a recent Cochrane review also failed to find in mortality benefit from head elevated position in mechanically ventilated patients (13). Similarly, benefit of a protocol driven ICU sedation is also not evident in another Cochrane review (14). Another important issue is that, this study aimed to delineate effects of checklist in short term period, a larger effect size may be found when these practices are implemented for longer term.
Encouraging input from this trial is that checklist and prompting improves adherence to practice standards particularly where baseline adherence is low but disappointing part is that at this time point there is no evidence that it improves clinical outcome.
Provenance: This is an invited Editorial commissioned by the Section Editor Zhongheng Zhang (Department of Emergency Medicine, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China).
Conflicts of Interest: The author has no conflicts of interest to declare.