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Antigenically drifted influenza A(H3N2) viruses circulated in 2014-2015, resulting in reduced vaccine effectiveness. Levine et al. (p. 831–839) examine neutralizing antibody responses to antigenically drifted viruses following vaccination with 2014-2015 live-attenuated influenza vaccine (LAIV) or inactivated influenza vaccine (IIV) among children and adolescents. IIV induced higher cross-reactive antibodies than LAIV. Antibody responses were influenced by preexisting immunity from prior exposure. IIV recipients who received LAIV in the prior season had the highest cross-reactive antibody responses. This study suggests that in an A(H3N2) vaccine-mismatched season, vaccination still induced cross-reactive antibodies to antigenically drifted viruses, although higher levels may be required for sufficient protection.