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Br J Ophthalmol. 1994 June; 78(6): 449–453.
PMCID: PMC504821

Optic nerve head blood flow using a laser Doppler velocimeter and haemorheology in primary open angle glaucoma and normal pressure glaucoma.


Optic disc blood flow velocity was measured in healthy patients, those with primary open angle glaucoma (POAG), and patients with normal pressure glaucoma (NPG). The velocity of the red blood cells (RBCs) in the capillaries of the optic nerve head (ONH) has been measured with a laser Doppler velocimeter (LDV), and blood viscosity has been evaluated notably by determining the aggregability of the RBCs with an erythroaggregameter. Our results in POAG patients and NPG patients showed that their optic nerve blood flow velocity was reduced and that the aggregability of the RBCs was increased. The hyperaggregability of the erythrocytes is responsible for the increase of the local viscosity in the papillary capillary network. These haemodynamic modifications observed in patients with glaucoma support the hypothesis of a vasogenic mechanism that could impair the optic nerve in glaucoma patients.

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Selected References

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  • Quigley HA, Anderson DR. Distribution of axonal transport blockade by acute intraocular pressure elevation in the primate optic nerve head. Invest Ophthalmol Vis Sci. 1977 Jul;16(7):640–644. [PubMed]
  • Anderson DR, Hendrickson AE. Failure of increased intracranial pressure to affect rapid axonal transport at the optic nerve head. Invest Ophthalmol Vis Sci. 1977 May;16(5):423–426. [PubMed]
  • Hayreh SS. The pathogenesis of optic nerve lesions in glaucoma. Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol. 1976 Mar-Apr;81(2):197–213. [PubMed]
  • Drance SM, Sweeney VP, Morgan RW, Feldman F. Studies of factors involved in the production of low tension glaucoma. Arch Ophthalmol. 1973 Jun;89(6):457–465. [PubMed]
  • Riva CE, Grunwald JE, Sinclair SH. Laser Doppler measurement of relative blood velocity in the human optic nerve head. Invest Ophthalmol Vis Sci. 1982 Feb;22(2):241–248. [PubMed]
  • Chien S. Shear dependence of effective cell volume as a determinant of blood viscosity. Science. 1970 May 22;168(3934):977–979. [PubMed]
  • Zannad F, Medeiros C, Voisin P, Bruntz JF, Stoltz F, Gilgenkrantz JM. Le syndrome d'hyperviscosité sanguine dans l'hypertension artérielle essentielle. Caractérisation et incidences cliniques. Arch Mal Coeur Vaiss. 1985 Oct;78(11):1706–1709. [PubMed]
  • Glacet-Bernard A, Chabanel A, Coscas G, Lelong F, Samama M. Elévation de l'agrégation érythrocytaire au cours des occlusions veineuses rétiniennes. J Fr Ophtalmol. 1990;13(10):500–505. [PubMed]
  • Snabre P, Bitbol M, Mills P. Cell disaggregation behavior in shear flow. Biophys J. 1987 May;51(5):795–807. [PubMed]
  • Klaver JH, Greve EL, Goslinga H, Geijssen HC, Heuvelmans JH. Blood and plasma viscosity measurements in patients with glaucoma. Br J Ophthalmol. 1985 Oct;69(10):765–770. [PMC free article] [PubMed]
  • Trope GE, Salinas RG, Glynn M. Blood viscosity in primary open-angle glaucoma. Can J Ophthalmol. 1987 Jun;22(4):202–204. [PubMed]
  • Foulds WS. 50th Bowman lecture. 'Blood is thicker than water'. Some haemorheological aspects of ocular disease. Eye (Lond) 1987;1(Pt 3):343–363. [PubMed]
  • Carter CJ, Brooks DE, Doyle DL, Drance SM. Investigations into a vascular etiology for low-tension glaucoma. Ophthalmology. 1990 Jan;97(1):49–55. [PubMed]
  • Forsdyke DR, Palfree RG, Takeda A. Formation of erythrocyte rouleaux in preheated normal serum: roles of albumin polymers and lysophosphatidylcholine. Can J Biochem. 1982 Jul;60(7):705–711. [PubMed]
  • Garcia-Salinas P, Trope GE, Glynn M. Blood viscosity in ocular hypertension. Can J Ophthalmol. 1988 Dec;23(7):305–307. [PubMed]
  • Pillunat LE, Stodtmeister R, Wilmanns I, Christ T. Autoregulation of ocular blood flow during changes in intraocular pressure. Preliminary results. Graefes Arch Clin Exp Ophthalmol. 1985;223(4):219–223. [PubMed]
  • Ulrich WD, Ulrich C, Bohne BD. Deficient autoregulation and lengthening of the diffusion distance in the anterior optic nerve circulation in glaucoma: an electro-encephalo-dynamographic investigation. Ophthalmic Res. 1986;18(5):253–259. [PubMed]
  • Weinstein JM, Duckrow RB, Beard D, Brennan RW. Regional optic nerve blood flow and its autoregulation. Invest Ophthalmol Vis Sci. 1983 Dec;24(12):1559–1565. [PubMed]
  • Othmane A, Bitbol M, Snabre P, Mills P. Influence of altered phospholipid composition of the membrane outer layer on red blood cell aggregation: relation to shape changes and glycocalyx structure. Eur Biophys J. 1990;18(2):93–99. [PubMed]

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