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J Clin Pathol. 1995 June; 48(6): 582–584.
PMCID: PMC502696

Histological features of the thyroid gland in a patient with lithium induced thyrotoxicosis.

Abstract

A 26 year old woman with lithium induced thyrotoxicosis is reported. The thyrotoxicosis was associated with a non-tender diffuse goitre and a low radioiodine uptake by the gland. The thyrotoxicosis was reversible and remitted on withdrawal of the drug. The histopathological alterations of the thyroid glad were characterised by extensive follicular cell disruption with no lymphocytic infiltration. It is postulated that lithium might directly damage thyroid follicular cells and that subsequent release of thyroglobulin into the circulation might be a cause of transient thyrotoxicosis.

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Selected References

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  • Schou M, Amdisen A, Eskjaer Jensen S, Olsen T. Occurrence of goitre during lithium treatment. Br Med J. 1968 Sep 21;3(5620):710–713. [PMC free article] [PubMed]
  • Brownlie BE, Chambers ST, Sadler WA, Donald RA. Lithium associated thyroid disease--a report of 14 cases of hypothyroidism and 4 cases of thyrotoxicosis. Aust N Z J Med. 1976 Jun;6(3):223–229. [PubMed]
  • Lindstedt G, Nilsson LA, Wålinder J, Skott A, Ohman R. On the prevalence, diagnosis and management of lithium-induced hypothyroidism in psychiatric patients. Br J Psychiatry. 1977 May;130:452–458. [PubMed]
  • Rosser R. Thyrotoxicosis and lithium. Br J Psychiatry. 1976 Jan;128:61–66. [PubMed]
  • Franklin LM. Thyrotoxicosis developing during lithium treatment: case report. N Z Med J. 1974 Mar 27;79(511):782–782. [PubMed]
  • Reus VI, Gold P, Post R. Lithium-induced thyrotoxicosis. Am J Psychiatry. 1979 May;136(5):724–725. [PubMed]
  • Kontozoglou T, Mambo N. The histopathologic features of lithium-associated thyroiditis. Hum Pathol. 1983 Aug;14(8):737–739. [PubMed]
  • Fauerholdt L, Vendsborg P. Thyroid gland morphology after lithium treatment. Acta Pathol Microbiol Scand A. 1981 Jul;89(4):339–341. [PubMed]
  • Berens SC, Bernstein RS, Robbins J, Wolff J. Antithyroid effects of lithium. J Clin Invest. 1970 Jul;49(7):1357–1367. [PMC free article] [PubMed]
  • Mizukami Y, Michigishi T, Nonomura A, Hashimoto T, Nakamura S, Tonami N, Takazakura E. Postpartum thyroiditis. A clinical, histologic, and immunopathologic study of 15 cases. Am J Clin Pathol. 1993 Sep;100(3):200–205. [PubMed]
  • Smyrk TC, Goellner JR, Brennan MD, Carney JA. Pathology of the thyroid in amiodarone-associated thyrotoxicosis. Am J Surg Pathol. 1987 Mar;11(3):197–204. [PubMed]
  • Carney JA, Moore SB, Northcutt RC, Woolner LB, Stillwell GK. Palpation thyroiditis (multifocal granulomatour folliculitis). Am J Clin Pathol. 1975 Nov;64(5):639–647. [PubMed]
  • Mizukami Y, Michigishi T, Nonomura A, Nakamura S, Ishizaki T. Pathology of chronic thyroiditis: a new clinically relevant classification. Pathol Annu. 1994;29(Pt 1):135–158. [PubMed]

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