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J Clin Pathol. 1990 February; 43(2): 106–113.
PMCID: PMC502289

Rheumatoid lymphadenopathy: a morphological and immunohistochemical study.


Sixteen lymph nodes from 14 patients with rheumatoid arthritis were examined immunohistochemically and morphometrically and compared with 10 control nodes showing follicular hyperplasia from patients without rheumatoid disease. Frozen material was available from nine patients and all controls. The nodes from patients with rheumatoid arthritis seemed to share characteristic features. The most striking of these was follicular hyperplasia in which the germinal centres, in spite of being quite large, showed relatively sparse proliferative activity. The nodes often showed infiltration of germinal centres by CD8 positive T lymphocytes and contained fewer IL2R positive cells in the paracortex than controls. These and other features may have some correlation with disease activity. Lymphadenopathy in rheumatoid arthritis may not just be a manifestation of joint inflammation but an active component of this multisystem disease and may reflect a widespread immunological abnormality.

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Selected References

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  • CRUICKSHANK B. Lesions of lymph nodes in rheumatoid disease and in disseminated lupus erythematosus. Scott Med J. 1958 Mar;3(3):110–119. [PubMed]
  • LEA AJ. AN ASSOCIATION BETWEEN THE RHEUMATIC DISEASES AND THE RETICULOSES. Ann Rheum Dis. 1964 Nov;23:480–484. [PMC free article] [PubMed]
  • Symmons DP, Ahern M, Bacon PA, Hawkins CF, Amlot PL, Jones EL, Prior P, Scott DL. Lymphoproliferative malignancy in rheumatoid arthritis: a study of 20 cases. Ann Rheum Dis. 1984 Apr;43(2):132–135. [PMC free article] [PubMed]
  • MOTULSKY AG, WEINBERG S, SAPHIR O, ROSENBERG E. Lymph nodes in rheumatoid arthritis. AMA Arch Intern Med. 1952 Nov;90(5):660–676. [PubMed]
  • Kelly CA, Malcolm AJ, Griffiths I. Lymphadenopathy in rheumatic patients. Ann Rheum Dis. 1987 Mar;46(3):224–227. [PMC free article] [PubMed]
  • Muirden KD. Lymph node iron in rheumatoid arthritis. Histology, ultrastructure, and chemical concentration. Ann Rheum Dis. 1970 Jan;29(1):81–88. [PMC free article] [PubMed]
  • Mageed RA, Walker MR, Jefferis R. Restricted light chain subgroup expression on human rheumatoid factor paraproteins determined by monoclonal antibodies. Immunology. 1986 Nov;59(3):473–478. [PubMed]
  • Kennedy TD, Plater-Zyberk C, Partridge TA, Woodrow DF, Maini RN. Morphometric comparison of synovium from patients with osteoarthritis and rheumatoid arthritis. J Clin Pathol. 1988 Aug;41(8):847–852. [PMC free article] [PubMed]
  • Janossy G, Tidman N, Selby WS, Thomas JA, Granger S, Kung PC, Goldstein G. Human T lymphocytes of inducer and suppressor type occupy different microenvironments. Nature. 1980 Nov 6;288(5786):81–84. [PubMed]
  • Dvoretsky P, Wood GS, Levy R, Warnke RA. T-lymphocyte subsets in follicular lymphomas compared with those in non-neoplastic lymph nodes and tonsils. Hum Pathol. 1982 Jul;13(7):618–625. [PubMed]
  • Modlin RL, Meyer PR, Hofman FM, Mehlmauer M, Levy NB, Lukes RJ, Parker JW, Ammann AJ, Conant MA, Rea TH, et al. T-lymphocyte subsets in lymph nodes from homosexual men. JAMA. 1983 Sep 9;250(10):1302–1305. [PubMed]
  • Wood GS, Burns BF, Dorfman RF, Warnke RA. In situ quantitation of lymph node helper, suppressor, and cytotoxic T cell subsets in AIDS. Blood. 1986 Mar;67(3):596–603. [PubMed]
  • Said JW, Shintaku IP, Teitelbaum A, Chien K, Sassoon AF. Distribution of T-cell phenotypic subsets and surface immunoglobulin-bearing lymphocytes in lymph nodes from male homosexuals with persistent generalized adenopathy: an immunohistochemical and ultrastructural study. Hum Pathol. 1984 Aug;15(8):785–790. [PubMed]
  • Kitas GD, Salmon M, Farr M, Gaston JS, Bacon PA. Deficient interleukin 2 production in rheumatoid arthritis: association with active disease and systemic complications. Clin Exp Immunol. 1988 Aug;73(2):242–249. [PubMed]
  • Salmon M, Bacon PA. A cellular deficiency in the rheumatoid one-way mixed lymphocyte reaction. Clin Exp Immunol. 1988 Jan;71(1):79–84. [PubMed]
  • Buchan G, Barrett K, Fujita T, Taniguchi T, Maini R, Feldmann M. Detection of activated T cell products in the rheumatoid joint using cDNA probes to Interleukin-2 (IL-2) IL-2 receptor and IFN-gamma. Clin Exp Immunol. 1988 Feb;71(2):295–301. [PubMed]
  • Papadimitriou GM, Bacon PA, Hall ND. Circulating activated lymphocytes in rheumatoid arthritis: a marker of synovial inflammation. J Rheumatol. 1982 Mar-Apr;9(2):217–223. [PubMed]
  • McCusker CT, Singal DP. Molecular relationships between the class II HLA antigens and susceptibility to rheumatoid arthritis. J Rheumatol. 1988 Jul;15(7):1050–1053. [PubMed]

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