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J Clin Pathol. 1994 March; 47(3): 269–271.
PMCID: PMC501910

Atypical progression of multiple myeloma with extensive extramedullary disease.


Multiple myeloma is a neoplastic disorder caused by the proliferation of a transformed B lymphoid progenitor cell that gives rise to a clone of immunoglobulin-secreting cells. Other plasma cell tumours include solitary plasmacytoma of bone (SPB) and extramedullary plasmacytomas (EMP). Despite an apparent common origin there exist pathological and clinical differences between these neoplasms and the association between them is not completely understood. A case of IgG multiple myeloma that presented with typical clinical and laboratory features, including a bone marrow infiltrated by well differentiated plasma cells, is reported. The tumour had an unusual evolution, with the development of extensive extramedullary disease while maintaining mature histological features.

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Selected References

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  • Jancelewicz Z, Takatsuki K, Sugai S, Pruzanski W. IgD multiple myeloma. Review of 133 cases. Arch Intern Med. 1975 Jan;135(1):87–93. [PubMed]
  • HAYES DW, BENNETT WA, HECK FJ. Extramedullary lesions in multiple myeloma; review of literature and pathologic studies. AMA Arch Pathol. 1952 Mar;53(3):262–272. [PubMed]
  • Foucar K, Raber M, Foucar E, Barlogie B, Sandler CM, Alexanian R. Anaplastic myeloma with massive extramedullary involvement. Report of two cases. Cancer. 1983 Jan 1;51(1):166–174. [PubMed]
  • Knowling MA, Harwood AR, Bergsagel DE. Comparison of extramedullary plasmacytomas with solitary and multiple plasma cell tumors of bone. J Clin Oncol. 1983 Apr;1(4):255–262. [PubMed]
  • Wiltshaw E. The natural history of extramedullary plasmacytoma and its relation to solitary myeloma of bone and myelomatosis. Medicine (Baltimore) 1976 May;55(3):217–238. [PubMed]
  • Corwin J, Lindberg RD. Solitary plasmacytoma of bone vs. extramedullary plasmacytoma and their relationship to multiple myeloma. Cancer. 1979 Mar;43(3):1007–1013. [PubMed]

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