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J Clin Pathol. 1994 March; 47(3): 227–231.
PMCID: PMC501900

Relation between IgG and IgA antibody titres against Helicobacter pylori in serum and severity of gastritis in asymptomatic subjects.


AIMS--To investigate whether the absorbance index of IgG and IgA antibodies against Helicobacter pylori is related to a semiquantitative assessment of the density of H pylori colonisation in gastric biopsy specimens and to the severity of gastritis. METHODS--The grade of gastritis was scored separately for antral and fundic mucosa using three different classifications. Serum IgA and IgG antibodies against H pylori were measured by ELISA. The density of gastric H pylori colonisation was graded semiquantitatively from 0 to 3. RESULTS--Among 48 healthy volunteers studied, 17 were found to have gastritis according to Whitehead's criteria. H pylori was present in the biopsy specimens of 14 of 17 subjects with gastritis. The IgG H pylori antibody absorbance index was significantly (p < 0.05) correlated not only with the density of antral H pylori colonisation, but also with the degree of gastritis of the antrum, as assessed by the Whitehead score, activity, and the Sydney system (p < 0.05). The IgA H pylori antibody absorbance index was significantly correlated with the Whitehead score and Sydney system, but not with the activity score of the antrum or with the density of antral gastric H pylori infection. There were no significant correlations between the IgG H pylori antibody absorbance index and the gastritis scores of the fundus mucosa and the density of H pylori infection of the gastric body. The IgA H pylori antibody absorbance index was only significantly (p < 0.05) correlated with the density of H pylori colonisation and the Sydney system gastritis score of the corpus. CONCLUSIONS--The serological absorbance index of IgG antibodies against H pylori is related to the severity of antral gastritis and the density of antral H pylori colonisation. Thus a high absorbance index of IgG antibodies against H pylori points to severe antral gastritis and dense H pylori colonisation of the antrum.

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Selected References

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  • Perez-Perez GI, Dworkin BM, Chodos JE, Blaser MJ. Campylobacter pylori antibodies in humans. Ann Intern Med. 1988 Jul 1;109(1):11–17. [PubMed]
  • Jones DM, Eldridge J, Fox AJ, Sethi P, Whorwell PJ. Antibody to the gastric campylobacter-like organism ("Campylobacter pyloridis")--clinical correlations and distribution in the normal population. J Med Microbiol. 1986 Aug;22(1):57–62. [PubMed]
  • Goodwin CS, Blincow E, Peterson G, Sanderson C, Cheng W, Marshall B, Warren JR, McCulloch R. Enzyme-linked immunosorbent assay for Campylobacter pyloridis: correlation with presence of C. pyloridis in the gastric mucosa. J Infect Dis. 1987 Mar;155(3):488–494. [PubMed]
  • Rauws EA, Langenberg W, Houthoff HJ, Zanen HC, Tytgat GN. Campylobacter pyloridis-associated chronic active antral gastritis. A prospective study of its prevalence and the effects of antibacterial and antiulcer treatment. Gastroenterology. 1988 Jan;94(1):33–40. [PubMed]
  • Peña AS, Endtz HP, Offerhaus GJ, Hoogenboom-Verdegaal A, van Duijn W, de Vargas N, den Hartog G, Kreuning J, van der Reyden J, Mouton RP, et al. Value of serology (ELISA and immunoblotting) for the diagnosis of Campylobacter pylori infection. Digestion. 1989;44(3):131–141. [PubMed]
  • Booth L, Holdstock G, MacBride H, Hawtin P, Gibson JR, Ireland A, Bamforth J, DuBoulay CE, Lloyd RS, Pearson AD. Clinical importance of Campylobacter pyloridis and associated serum IgG and IgA antibody responses in patients undergoing upper gastrointestinal endoscopy. J Clin Pathol. 1986 Feb;39(2):215–219. [PMC free article] [PubMed]
  • Newell DG, Johnston BJ, Ali MH, Reed PI. An enzyme-linked immunosorbent assay for the serodiagnosis of Campylobacter pylori-associated gastritis. Scand J Gastroenterol Suppl. 1988;142:53–57. [PubMed]
  • Veenendaal RA, Biemond I, Peña AS, van Duijn W, Kreuning J, Lamers CB. Influence of age and Helicobacter pylori infection on serum pepsinogens in healthy blood transfusion donors. Gut. 1992 Apr;33(4):452–455. [PMC free article] [PubMed]
  • Harries AD, Stewart M, Deegan KM, Mughogho GK, Wirima JJ, Hommel M, Hart CA. Helicobacter pyrlori in Malawi, central Africa. J Infect. 1992 May;24(3):269–276. [PubMed]

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