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J Clin Pathol. 1994 January; 47(1): 80–82.
PMCID: PMC501763

Oncogenic hypophosphataemia and ectopic corticotrophin secretion due to oat cell carcinoma of the trachea.


A case of oat cell carcinoma causing Cushing's syndrome and oncogenic hypophosphataemic osteomalacia is reported. The association of the two disorders in one patient is believed to be unique and this is the second reported case of oncogenic osteomalacia caused by oat cell carcinoma.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Paterson CR, Naismith KI, Young JA. Severe unexplained hypophosphatemia. Clin Chem. 1992 Jan;38(1):104–107. [PubMed]
  • Drezner MK, Feinglos MN. Osteomalacia due to 1alpha,25-dihydroxycholecalciferol deficiency. Association with a giant cell tumor of bone. J Clin Invest. 1977 Nov;60(5):1046–1053. [PMC free article] [PubMed]
  • Taylor HC, Fallon MD, Velasco ME. Oncogenic osteomalacia and inappropriate antidiuretic hormone secretion due to oat-cell carcinoma. Ann Intern Med. 1984 Dec;101(6):786–788. [PubMed]
  • Ryan EA, Reiss E. Oncogenous osteomalacia. Review of the world literature of 42 cases and report of two new cases. Am J Med. 1984 Sep;77(3):501–512. [PubMed]
  • Aschinberg LC, Solomon LM, Zeis PM, Justice P, Rosenthal IM. Vitamin D-resistant rickets associated with epidermal nevus syndrome: demonstration of a phosphaturic substance in the dermal lesions. J Pediatr. 1977 Jul;91(1):56–60. [PubMed]
  • Seshadri MS, Cornish CJ, Mason RS, Posen S. Parathyroid hormone-like bioactivity in tumours from patients with oncogenic osteomalacia. Clin Endocrinol (Oxf) 1985 Dec;23(6):689–697. [PubMed]
  • Hewison M, Karmali R, O'Riordan JL. Tumour induced osteomalacia. Clin Endocrinol (Oxf) 1992 Oct;37(4):382–384. [PubMed]

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