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J Clin Pathol. 1999 November; 52(11): 849–850.
PMCID: PMC501601

CD10 positive thyroid marginal zone non-Hodgkin lymphoma.


A 72 year old woman presented with swelling of the right lobe of her thyroid gland. Fine needle aspiration and flow cytometry showed a clonal population of B cells expressing CD10 and a diagnosis of follicle centre cell lymphoma was made. Subsequent excision of the thyroid showed the typical histological features of a marginal zone non-Hodgkin lymphoma. Polymerase chain reaction showed no evidence of t (14;18). Immunohistochemistry confirmed CD10 positivity and LN1 (CDw75) expression. This is only the second report of aberrant expression of CD 10 by a marginal zone lymphoma.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Isaacson PG. Malignant lymphomas with a follicular growth pattern. Histopathology. 1996 Jun;28(6):487–495. [PubMed]
  • Ballesteros E, Osborne BM, Matsushima AY. CD5+ low-grade marginal zone B-cell lymphomas with localized presentation. Am J Surg Pathol. 1998 Feb;22(2):201–207. [PubMed]
  • Phillips AJ, Tomasec P, Wang EC, Wilkinson GW, Borysiewicz LK. Human cytomegalovirus infection downregulates expression of the cellular aminopeptidases CD10 and CD13. Virology. 1998 Oct 25;250(2):350–358. [PubMed]

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