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J Clin Pathol. 1999 September; 52(9): 705–707.
PMCID: PMC501551

Granulocytic sarcoma preceding AML M0 and the diagnostic value of CD34.


Granulocytic sarcoma with no demonstrable abnormalities in the peripheral blood or bone marrow is a rare but recognised initial manifestation of acute myeloid leukaemia and has led to diagnostic difficulties in some cases. A lymph node excisional biopsy from a patient presenting with cervical lymphadenopathy, a mediastinal mass, and a normal peripheral blood picture was reported to have features suggesting a T cell non-Hodgkin lymphoma, for which she was subsequently treated. However, 10 months later the patient developed acute myeloid leukaemia, FAB classification M0. The initial lymph node biopsy was reviewed and further immunohistochemical studies using antibodies against CD34 led to a revised diagnosis of primary granulocytic sarcoma.

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Selected References

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  • Grange MJ, Cywiner-Golenzer C, Caen JP. Granulocytic sarcoma of the small intestine: a case report. Nouv Rev Fr Hematol. 1988;30(4):251–253. [PubMed]
  • Mansi JL, Selby PJ, Carter RL, Powles RL, McElwain TJ. Granulocytic sarcoma: a diagnosis to be considered in unusual lymphoma syndromes. Postgrad Med J. 1987 Jun;63(740):447–449. [PMC free article] [PubMed]
  • van Veen S, Kluin PM, de Keizer RJ, Kluin-Nelemans HC. Granulocytic sarcoma (chloroma). Presentation of an unusual case. Am J Clin Pathol. 1991 Apr;95(4):567–571. [PubMed]
  • Traweek ST, Arber DA, Rappaport H, Brynes RK. Extramedullary myeloid cell tumors. An immunohistochemical and morphologic study of 28 cases. Am J Surg Pathol. 1993 Oct;17(10):1011–1019. [PubMed]
  • Traweek ST. Immunophenotypic analysis of acute leukemia. Am J Clin Pathol. 1993 Apr;99(4):504–512. [PubMed]
  • Byrd JC, Edenfield WJ, Shields DJ, Dawson NA. Extramedullary myeloid cell tumors in acute nonlymphocytic leukemia: a clinical review. J Clin Oncol. 1995 Jul;13(7):1800–1816. [PubMed]

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