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J Clin Pathol. 1993 September; 46(9): 874–875.
PMCID: PMC501531

Multinucleated stromal giant cells of the colonic lamina propria in ulcerative colitis.


Multinucleated stromal giant cells were seen in the colonic mucosa in biopsy specimens from two patients with long-standing quiescent ulcerative colitis. Similar cells have been described at other sites associated with chronic inflammation, including the lower female genital tract, bladder and anus. The immunophenotype of the cells in the colonic mucosa suggested that they had originated from fibroblasts rather than histiocytes, in common with cells seen at other sites of inflammation. These examples lend support to the concept of there being a reactive morphological change possibly related to interaction with mast cells. These multinucleated giant cells are distinct from histiocytic giant cells and should not be confused with them.

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Selected References

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  • Pitt MA, Roberts IS, Agbamu DA, Eyden BP. The nature of atypical multinucleated stromal cells: a study of 37 cases from different sites. Histopathology. 1993 Aug;23(2):137–145. [PubMed]
  • Abdul-Karim FW, Cohen RE. Atypical stromal cells of lower female genital tract. Histopathology. 1990 Sep;17(3):249–253. [PubMed]
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  • Campbell AP. Multinucleated stromal giant cells in adolescent gynaecomastia. J Clin Pathol. 1992 May;45(5):443–444. [PMC free article] [PubMed]
  • Lloyd G, Green FH, Fox H, Mani V, Turnberg LA. Mast cells and immunoglobulin E in inflammatory bowel disease. Gut. 1975 Nov;16(11):861–865. [PMC free article] [PubMed]

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