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Logo of jclinpathJournal of Clinical PathologyCurrent TOCInstructions for authors
J Clin Pathol. Nov 1996; 49(11): 950–951.
PMCID: PMC500840
Malignant melanoma showing smooth muscle differentiation.
S S Banerjee, P W Bishop, C M Nicholson, and B P Eyden
Department of Pathology, Christie Hospital, Manchester.
A unique case of a metastatic non-desmoplastic sarcomatoid malignant melanoma in an axillary lymph node showing smooth muscle differentiation in a 54 year old woman is described. The tumour cells exhibited alpha-smooth muscle actin, HHF-35 and desmin positivity but were negative for S100 protein and HMB-45. Ultrastructural examination revealed smooth muscle phenotype and there was no evidence of myofibroblastic differentiation, a feature described previously in desmoplastic melanomas.
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