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J Clin Pathol. 1996 May; 49(5): 420–422.
PMCID: PMC500486

Alpha-fetoprotein production by a hepatoid adenocarcinoma of the uterus.

Abstract

A case of a 62 year old Japanese woman with an endometrial adenocarcinoma producing alpha-fetoprotein (AFP) is described. Microscopically, the tumour was composed of a major medullary portion and a minor tubular adenocarcinoma which had invaded the myometrium, the myometrial lymphatics and blood vessels. Neoplastic cells in the medullary portion were polygonal with glycogen-rich cytoplasm. Vascular permeation by neoplastic cells was prominent. Extensive hepatoma-like features were observed. The tumour cells lacked features suggestive of a diagnosis of embryonal carcinoma or endodermal sinus tumour. The production of AFP by the tumour cells was demonstrated immunohistochemically using the PAP technique. Only two cases of AFP producing endometrial adenocarcinomas have been reported previously.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Pileri S, Martinelli G, Serra L, Bazzocchi F. Endodermal sinus tumor arising in the endometrium. Obstet Gynecol. 1980 Sep;56(3):391–396. [PubMed]
  • Ohta M, Sakakibara K, Mizuno K, Kano T, Matsuzawa K, Tomoda Y, Nakashima N, Ogawa T. Successful treatment of primary endodermal sinus tumor of the endometrium. Gynecol Oncol. 1988 Oct;31(2):357–364. [PubMed]
  • Clement PB, Young RH, Scully RE. Extraovarian pelvic yolk sac tumors. Cancer. 1988 Aug 1;62(3):620–626. [PubMed]
  • Joseph MG, Fellows FG, Hearn SA. Primary endodermal sinus tumor of the endometrium. A clinicopathologic, immunocytochemical, and ultrastructural study. Cancer. 1990 Jan 15;65(2):297–302. [PubMed]
  • Kawagoe K. A case of mixed mesodermal tumor of the uterus with alpha-fetoprotein production. Jpn J Clin Oncol. 1985 Sep;15(3):577–583. [PubMed]
  • Matsukuma K, Tsukamoto N. Alpha-fetoprotein producing endometrial adenocarcinoma: report of a case. Gynecol Oncol. 1988 Mar;29(3):370–377. [PubMed]
  • Kubo K, Lee GH, Yamauchi K, Kitagawa T. Alpha-fetoprotein-producing papillary adenocarcinoma originating from a uterine body. A case report. Acta Pathol Jpn. 1991 May;41(5):399–403. [PubMed]
  • Ma CK, Zarbo RJ, Frierson HF, Jr, Lee MW. Comparative immunohistochemical study of primary and metastatic carcinomas of the liver. Am J Clin Pathol. 1993 May;99(5):551–557. [PubMed]
  • Sinard J, Macleay L, Jr, Melamed J. Hepatoid adenocarcinoma in the urinary bladder. Unusual localization of a newly recognized tumor type. Cancer. 1994 Apr 1;73(7):1919–1925. [PubMed]
  • Yamashita K, Taketa K, Nishi S, Fukushima K, Ohkura T. Sugar chains of human cord serum alpha-fetoprotein: characteristics of N-linked sugar chains of glycoproteins produced in human liver and hepatocellular carcinomas. Cancer Res. 1993 Jul 1;53(13):2970–2975. [PubMed]

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