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J Clin Pathol. 1985 September; 38(9): 985–988.
PMCID: PMC499346

Splenic pathology in immune thrombocytopenia.

Abstract

Splenic pathology was analysed in 73 patients with immune thrombocytopenic purpura who underwent splenectomy for bleeding that had been resistant to adrenocorticosteroids. The mean splenic weight was 100 g. The only notable macroscopic feature was the prominence of Malpighian corpuscles in 15 cases. Microscopic examination showed formation of germinal centres in the lymphoid tissue of the white pulp in 40 cases, prominence of the histiocytes in the red pulp in 18 cases, and infiltration with neutrophils in the same area in 49 cases. Myeloid metaplasia throughout the splenic tissue was minimal in 58 cases, moderate in 15, and extreme in two. No distinguishing features were found in the spleen from patients who had not received previous immunosuppressive treatment (n = 3), those treated with prednisone (1 mg/kg/day) for a median of 14 days (n = 62), or those who had received the same dose of prednisone and additional azathioprine or cyclophosphamide (2 mg/kg/day) for a median of four weeks (n = 8). No correlation could be shown between histological features and the age of the patient or titre of antiplatelet antibodies. Similarly, no distinguishing features were found in patients with associated systemic lupus erythematosus (n = 8), hyperthyroidism (n = 6), immune haemolysis (n = 3), or recent viral illness (n = 3).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Burke JS. Surgical pathology of the spleen: an approach to the differential diagnosis of splenic lymphomas and leukemias. Part II. Diseases of the red pulp. Am J Surg Pathol. 1981 Oct;5(7):681–694. [PubMed]
  • Tavassoli M, McMillan R. Structure of the spleen in idiopathic thrombocytopenic purpura. Am J Clin Pathol. 1975 Aug;64(2):180–191. [PubMed]
  • Nickerson DA, Sunderland DA. The Histopathology of Idiopathic Thrombocytopenic Purpura Hemorrhagica. Am J Pathol. 1937 May;13(3):463–490.3. [PubMed]
  • Yam LT, McMillian R, Tavassoli M, Crosby WH. Splenic hemopoiesis in idiopathic thrombocytopenic purpura. Am J Clin Pathol. 1974 Dec;62(6):830–837. [PubMed]
  • BOWMAN HE, PETTIT VD, CALDWELL FT, SMITH EB. Morphology of the spleen in idiopathic thrombocytopenic purpura. Lab Invest. 1955 May-Jun;4(3):206–216. [PubMed]
  • McMillan R. Chronic idiopathic thrombocytopenic purpura. N Engl J Med. 1981 May 7;304(19):1135–1147. [PubMed]
  • Jacobs P, Majoos F, Perrotta A. Hyperthyroidism and immune thrombocytopenia. Postgrad Med J. 1984 Oct;60(708):657–661. [PMC free article] [PubMed]
  • McMillan R, Smith RS, Longmire RL, Yelenosky R, Reid RT, Craddock CG. Immunoglobulins associated with human platelets. Blood. 1971 Mar;37(3):316–322. [PubMed]
  • PITCOCK JA, REINHARD EH, JUSTUS BW, MENDELSOHN RS. A clinical and pathological study of seventy cases of myelofibrosis. Ann Intern Med. 1962 Jul;57:73–84. [PubMed]
  • SALTZSTEIN SL. Phospholipid accumulation in histiocytes of splenic pulp associated with thrombocytopenic purpura. Blood. 1961 Jul;18:73–88. [PubMed]
  • Söderström N, Bandmann U, Lundh B. Patho-anatomical features of the spleen and liver. Clin Haematol. 1975 Jun;4(2):309–329. [PubMed]

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