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Br J Radiol. May 2016; 89(1061): 20150866.
Published online 2016 March 4. doi:  10.1259/bjr.20150866
PMCID: PMC4985465

The role of interventional radiology in abdominopelvic trauma

Abstract

The management of trauma patients has evolved in recent decades owing to increasing availability of advanced imaging modalities such as CT. Nowadays, CT has replaced the diagnostic function of angiography. The latter is considered when a therapeutic option is hypothesized. Arterial embolization is a life-saving procedure in abdominopelvic haemorrhagic patients, reducing relevant mortality rates and ensuring haemodynamic stabilization of the patient. Percutaneous transarterial embolization has been shown to be effective for controlling ongoing bleeding for patients with high-grade abdominopelvic injuries, thereby reducing the failure rate of non-operative management, preserving maximal organ function. Surgery is not always the optimal solution for stabilization of a patient with polytrauma. Mini-invasivity and repeatability may be considered as relevant advantages. We review technical considerations, efficacy and complication rates of hepatic, splenic, renal and pelvic embolization to extrapolate current evidence about transarterial embolization in traumatic patients.

INTRODUCTION

Injuries are the third leading cause of death across all ages.1 Active bleeding is the most common cause of death among trauma patients. While surgery is often considered the definitive treatment for bleeding control, it may not always be the optimal solution for stabilization of a patient with polytrauma. Specifically, arterial haemorrhage arising from pelvic fractures13 and solid organ injuries46 is amenable to management with angiography and embolization.

Abdominopelvic injuries present a challenge for the emergency department. A multidisciplinary team, comprising an orthopaedic trauma surgeon, a general surgeon, an anaesthesiologist, a radiologist and an interventional radiologist, evaluates each case.

All the protocols5 reported in literature are based on the “damage control orthopaedics (DCO)”;3,6 therefore any intervention, as rapid as possible, should be focused on haemorrhage control and on other life-saving measures. The arterial inflow arrest, pelvic sling and external fixation devices for pelvic fractures, direct surgical haemostasis, angiography and embolization represent treatment options that should be considered for the emergency haemostasis of abdominopelvic traumas.4,5 External devices, easily applied, can be used effectively.36

Owing to the lack of randomized trials evaluating the efficacy of arterial embolization in the trauma setting, the Eastern Association for the Surgery of Trauma guidelines offered Level 2 recommendations for angiography and embolization as a first-line treatment of liver injuries “for a patient who is a transient responder to resuscitation as an adjunct to potential operative intervention”.7

Several studies8,9 have demonstrated a valuable role for angiography and embolization in these settings.

The purpose of this study was to evaluate and review indications, techniques, results, complications and future developments in utilization of angiography and embolization for abdominopelvic traumatic patients.

MATERIALS AND METHODS

A review of international literature on abdominopelvic traumatic lesions, pelvic ring fractures and angioembolization was carried out through PubMed with the following medical subject heading: “blunt abdominal/liver/spleen/renal trauma”, “retroperitoneal bleeding/trauma”, “pelvic fractures/injury/trauma/bleeding” and “transarterial embolization/interventional radiology”.

All titles and abstracts of studies identified in the initial search were screened to identify those reporting on patients with traumatic lesions of solid organs or pelvic bleeding undergoing transarterial embolization (TAE) as one of the initial life-saving interventions. We identified additional studies through hand searches of bibliographies from primary studies, review articles and key journals. Case reports, small series revisions and articles that contained data reported previously were excluded and only articles in the English language or published after 2002 were included. Articles were considered eligible for inclusion in the present review if at least one outcome of interest was described; if articles dealing with traumatic and non-traumatic causes of bleeding, traumatic patients were extracted.

The following variables were extracted, where available, from the included articles: number of patients; trauma and its grading on the basis of American Association for the Surgery of Trauma Organ Injury (AAST),10,11 associated lesions, injury severity score (ISS),12 number of sessions of treatment, embolic agent used, technical success, clinical success, rebleeding rate, complication and mortality rate. Data are reported as described in the studies: authors sometimes reported a range and/or a median value and sometimes reported a rate and/or a value.

Before extracting data from the eligible studies, clear definitions of all outcomes of interest were established. Efficacy rate of TAE was defined as the frequency of successful embolizations in each study. Successful embolization was defined as cessation of contrast medium extravasation in post-TAE imaging without any need for further intervention (repeat TAE or surgical approach), as clearly mentioned in each manuscript. Mortality was defined as early patients’ death before discharge, with the following causes: persistent haemorrhage, concomitant trauma and complications (adult respiratory distress syndrome, multiple organ failure, sepsis). Mortality due to all above causes was defined as overall mortality. Angio-related complications were those associated with the angiography and embolization procedures, such as major puncture site complications (haematoma, infection, femoral artery dissection, aneurysm or pseudoaneurysm formation, a–v fistula, leg ischaemia); gluteal muscle, bladder or intestinal necrosis; liver or renal failure, ischaemia of the gallbladder, abscesses of large necrotic areas (hepatic, splenic or retroperitoneal), major allergic reactions.

RESULTS

Liver injuries

We selected a total of 10 studies,1322 involving a total of 360 patients (Table 1).

Table 1.
Authors, patients and their traumatic characteristics, embolic agent used, number of sessions, technical and clinical successes, cases of rebleedings, complications and mortality rates

Mechanism of injury was not specified in all studies,1322 even if motor vehicle accident was the most frequent cause1322 (Figure 1a–c).

Figure 1.
Arterial phase of contrast-enhanced CT revealed an extensive active bleed (a); selective angiogram confirmed bleed (b); final angiogram performed after embolization with sponge and coils (c).

The AAST grade of liver injury was reported in almost all the studies,13,15,17,2022 in particular in a total of 172 patients, as reported below, 18 Grade II, 53 Grade III, 77 Grade IV, 23 Grade V injuries.

Mean ISS was reported in only two studies15,18 having an overall mean value of 20.47. Associated lesions were not specified;1322 authors often reported multiple associated injuries.

In almost all the studies,1416,18,2022 materials used to embolize were coils, gelfoam and polyvinyl alcohol particles (PVA). The choice of the materials used to embolize was based on the operator's preference and expertise (Figure 2a–c).

Figure 2.
Initial arteriography revealed a little pseudoaneurysm (PSA) (arrow) (a); PSA was embolized with a microcoil (arrow) deployed proximally on the basis of the tortuosity of the vessel (b); final angiogram confirmed complete embolization (c).

Technical success was reported in nine studies,1319,21,22 with a mean value of 94.9%; distributed as follows: 100% (n = 7); 81.2% (n = 1); and 73% (n = 1).

Clinical success was reported in nine studies,1321 with a mean value of 79.8% in particular: 100% (n = 3); 98.3% (n = 1); 95.5% (n = 1); 93% (n = 1); 88.8% (n = 1); 85.7% (n = 1); and 50% (n = 1).

Rebleeding rate was another data mostly not reported.13,16,19,21,22 In some cases, when reported,14,15,17,18,20 a second transarterial embolization was performed.

Complications were reported in nine studies.1422 Complications have been described differently; on the basis of the definitions of the present review, complications related to embolization were gallbladder infarction, hepatic necrosis, liver abscess described by Kong et al.21 Monnin et al15 registered two cases of gallbladder infarction but they did not attribute it to embolization.

Most of the complications described were managed conservatively; cholecystectomy was performed when necessary.15 Misselbeck et al16 described nine complications after TAE (three managed operatively) and in total they described only one death related to liver failure.

The overall mortality rate was usually related to concomitant trauma or to uncontrolled haemorrhage (Table 1).1519,22 Embolization was never described as a direct cause of death, it may be considered as a co-factor (for example, the death described by Misselbeck et al16 for liver failure or the two deaths for liver infections reported by Lee et al22).

Spleen injuries

We identified 20 studies,2342 involving a total of 939 patients who underwent splenic angioembolization (SAE) for traumatic lesions (Table 2). All 20 studies that were included were retrospective cohort studies.

Table 2.
Authors, patients and their traumatic characteristics, embolic agent used, number of sessions, technical and clinical successes, cases of rebleedings, complications and mortality rates

All included patients sustained blunt mechanism of injury, and the overall mean America Association for the Surgery of Trauma Organ Injury (AAST)–Organ Injury Scale (OIS),6,8 AAST-OIS grade of splenic injuries was 3.65. In the table, mean value is indicated because most of the studies reported it.

SAE could be distal (selective), proximal (splenic artery) or combined.43 Proximal embolization was performed significantly more often than distal embolization (601 patients vs 144 patients; 64% vs 15.33%).2325,2740 A combination of both techniques was applied in only 30 patients (3.19%).2325,2740 In 164 patients (17.35%), SAE procedure was not described in detail (three studies)26,41,42 (Figure 3a–e).

Figure 3.
Contrast-enhanced CT revealed splenic haematoma with active bleeding (a); selective angiogram confirmed active bleeding (b); angiogram performed after embolization with coils (c); ultrasound performed during follow-up showed a subcapsular ipoanechoic ...

Embolic agents used were coils or gelatine particles in 417 patients (11 studies), vascular plugs in 13 patients (1 study35), coils or PVA particles in 1 study (13 patients25) (Figure 4a–d).

Figure 4.
CT revealed voluminous splenic haematoma with arterial bleeding in the context (a); selective angiography of the intrasplenic bleeder (b); complete embolization with ethylene vinyl alcohol copolymer (c); final angiogram showed complete embolization of ...

Technical success was described in seven studies, with a mean value of 93.3%, with complete exclusion of the lesion.2730,33,40 Clinical success was reported in 19 studies.2341

In some studies,26,27 the effectiveness of SAE could be masked when the outcomes of patients treated with observational management and SAE are combined in terms of non-operative management. Average rate is 84.6%.

In 60 cases (6.38%), bleeding recurrence was observed;24,25,2732,34,3640 Haan et al32 observed 27 persistent splenic pseudoaneurysm (PSA) and 5 new splenic PSA after first coil embolization. In a total of 25 patients,32 splenectomy was required (splenectomy was required for infectious complications in 4 patients), and in 4 patients, splenic angiography was performed again,32 with a mean SAE failure rate of 14.67% and clinical success ranged from 67.6% to 100% (mean 84.33%). Other complications described were splenic abscess, delayed splenic infarction, splenic artery dissection, femoral artery dissection and femoral arteriovenous fistula, coils migration (Table 2).27,30,33,42

Smith et al30 failed non-operative/SAE management in 27% of patients. None of the patients (n = 9) with low-grade injury (I, II) and mild or absent haemoperitoneum failed transarterial embolization, whereas 10 of the 23 patients (43%) with high-grade injury (III, IV, V) and moderate or large haemoperitoneum failed.

Renal injuries

We selected a total of 20 studies,4463 involving a total of 306 patients (Table 3) (Figure 5a–c).

Table 3.
Authors, patients and their traumatic characteristics, embolic agent used, number of sessions, technical and clinical successes, cases of rebleedings, complications and mortality rates
Figure 5.
Contrast-enhanced CT showed renal haematoma with active arterial bleeding in the context (a); selective angiogram confirmed active bleeding (b); angiogram performed at the end of embolization with ethylene vinyl alcohol copolymer (c).

Mechanism of injury was not specified in three studies.54,55,59 When reported,4453,5658,6063 the cause was blunt renal trauma (majority caused by motor vehicle accidents) in 87.4% of the cases and penetrating injuries (gunshot or stab wounds) in 12.6% of the cases.

The AAST grade of renal injury was reported in almost all the studies as reported below: 9.1% Grade II injuries, 18.2% Grade III, 50.48% Grade IV, 22.59% Grade V injuries.

Mean ISS was reported in only eight studies,5052,55,5861 having an overall mean value of 23.37. The most frequently associated lesions were pelvic bleeding in 23.4% of the reported cases, thorax injuries in 23.4% of the cases, spleen injuries in 21.2%, liver injuries in 17% and central nervous system injuries in 14.8%.

In half of the studies,48,50,54,55,5760 there were no reported data on the materials used to embolize. However, in the studies4447,49,5153,56,6163 that reported embolic materials they were distributed as follows: 47.8% coils, 21.7% coils and gelfoam combined, 18.4% only gelfoam, 6.5% glue, 3% Onyx, 2% PVA. The choice of the materials used to embolize was based on the operator's preference and expertise (Figure 6a–e).

Figure 6.
CT showed renal haematoma with two little arterial bleeds in the context: axial view (a) and coronal MIP view (b); selective angiogram of the left kidney confirmed the two little bleeds (white arrows) (c); the upper bleed was embolized with ethylene vinyl ...

Technical success was 96.2%. Clinical success was 90.92%. Rebleeding rate was mostly reported,4448,5058,6063 having an overall rate of 25.6%. The overall mortality rate was 8.5%.4448,5056,58,6163

Pelvic injuries

We selected a total of 13 studies,3,6475 involving a total of 627 patients (Table 4) (Figure 7a–e).

Table 4.
Authors, patients and their traumatic characteristics, embolic agent used, number of sessions, technical and clinical successes, cases of rebleedings, complications and mortality rates
Figure 7.
Arterial (a) and venous (b) phases of contrast-enhanced CT in multiple pelvic fractures revealed active bleed; selective (c) and superselective (d) angiogram confirmed multiple active bleeds, embolized with ethylene vinyl alcohol copolymer (e).

Mechanism of injury was not always reported.65,6769,7275 When reported,3,64,66,68,70,71,73,74 the major cause was motor vehicle accidents; pedestrian accidents, crushs, falls, train accidents and stabbings were the less frequently reported causes.3,64,66,68,70,71,73,74 The AAST grade was not specified;3,6475 in some studies,66,6870 patients were haemodynamically unstable. Haemodynamic instability was defined as systolic arterial pressure <90 mmHg after an additional infusion of normal saline (generally 500–1000 ml) and a continuous infusion of dopamine was started.1,10,12 In most cases, thoracic and abdominal bleeding, cardiac tamponade and pneumothorax tension were investigated simultaneously to pelvic haemorrhages.64,6775 Laparotomy was indicated by concomitant haemodynamic instability and progressive abdominal effusion or by the existence of a pneumoperitoneum. The most frequently associated lesions were multiple lesions, in particular involving abdominal organs.64,6775

In the case of combined intraperitoneal and retroperitoneal bleeding, the attending physician could choose pelvic angiography or exploratory laparotomy as the first-line treatment.76

Mean ISS was reported in 11 studies;6569,7175 in most of them, a mean value or a range is reported.6567,69,7175

In most studies,65,66,68,69,7175 there were no reported data on the materials used to embolize. However, in the studies3,64,67,70 that reported embolic materials they were coils, gelfoam, coils and gelfoam combined, particles and plug3,64,67,70 (Figure 8a–e). The choice of the materials used to embolize was based on the operator's preference and expertise. Technical success was reported in 11 studies;3,6875 the overall rate is 98.9%.

Figure 8.
CT showed a voluminous pseudoaneurysm (a); coronal MIP reconstruction revealed the afferent vessel (b); selective angiogram confirmed the pseudoaneurysm (c); final angiography confirmed complete embolization (d); embolization was performed with 2 amplatzer ...

Clinical success was reported in 10 studies;3,64,6773,75 the overall rate is 91.75%. Rebleeding rate was reported in 10 studies,3,64,6773,75 having an overall rate of 9.7%. Among the cases of rebleedings, some were from new sites or from controlateral sites.72,75

The overall mortality rate was 15.3%;3,6475 however, none described deaths related to the procedure of embolization (Table 4); Sarin et al65 did not indicate the cause of deaths registered.

DISCUSSION

The main purpose of the present review was to evaluate and analyse indications, techniques, results, complications and future developments of arterial embolization in abdominopelvic haemorrhages.

In the last years,77 a significant decreasing utilization for angiography was registered. Improved patient selection for angiography may have been a factor contributing to decreased use.

Contrast-enhanced CT has revolutionized the diagnosis, management and treatment of trauma patients, demonstrating most of the lesions in a single examination.

Whole body contrast-enhanced CT should be the first-line imaging modality in severely injured patients who respond at least partially to resuscitation.

Early whole body CT improves outcome, shortening the decision time. Its aim is to indicate whether haemostatic control is best achieved by non-operative management, interventional radiology or damage control surgery.

The Eastern Association for the Surgery of Trauma first published guidelines for the management of haemorrhage in patients with pelvic fractures in 2001.78

The same group published the first set of guidelines for the management of hepatic injuries in 2003; an update in 2012 gave similar recommendations for the role of angiography.7 In the same year, the same group published guidelines for non-operative management of blunt splenic injury.79 Four years before, Raikhlin et al80 had already reviewed literature about splenic embolization focusing to its technique (proximal, distal, combined), its efficacy and safety and residual splenic immunological function and risk of infection.

In 2004, Santucci et al9 published a consensus document on renal injury. One year later, Lynch et al81 published the European Association of Urology guidelines on urological trauma (update 2009).

In 2012, Cardiovascular and Interventional Radiology Society of Europe published guidelines for endovascular treatment of traumatic haemorrhage76 on the basis of those proposed by Oxford Centre for Evidence-based Medicine. Interventional radiology and imaging play an important role in severely traumatic patients, as this document shows.

All included studies were case series: a clearly defined protocol for angiographic intervention was missing, and incomplete description of all outcomes of interest was available. Studies were clinically and methodologically heterogeneous, on the basis of different design, conduct, demographic factors, therapeutic interventions, resuscitation data and outcomes, as consequence bias in the results are inevitable. Moreover, some studies include haemorrhages with different causes, and we extrapolated traumatic patients and data about procedures, results, outcomes and complications; possible errors of interpolation and/or interpretation should be considered.

The lack of randomized control trials does not allow one treatment method to be stabily superior over the other. However, the review of case series about abdominopelvic traumatic lesions of the last 13 years confirmed TAE as a highly effective technique in controlling life-threatening haemorrhages.

Efficacy rate was based on three substantive criteria: cessation of contrast extravasation on post-TAE angiography; improvement of patients’ haemodynamics; and avoidance of further interventions to control exsanguination from the districts examined (no further TAE or urgent laparatomy/pelvic packing). Technical success, clinical success and rebleeding rates resulted high in all the districts considered, in particular ranged from 93.3% to 98.9% (splenic and pelvic embolization, respectively), from 79.8% to 91.75% (liver and pelvic embolization, respectively) and from 6.38% to 25.6% (splenic and renal embolization, respectively). Most of the studies16,18,48,62,72,73 recorded high percentages of other arterial bleeding sites than the ones initially embolized, probably for the profuse vasoconstriction during the initial shock state that had obscured arterial bleeding sites during the primary angiographic procedure. It is unclear whether an open approach (instead of TAE) could have resulted in a more efficacious haemorrhage control with less complications in recurrent bleeding, either from the primarily embolized site or from new arterial bleeding sites.

Overall mortality can be attributed to massive uncontrolled haemorrhage; concomitant trauma; lethal complications (adult respiratory distress syndrome, multiple organ failure, sepsis). Our data about overall mortality are heterogeneous therefore an overall value cannot be given. Deaths related to the procedure of embolization are not reported; furthermore, some authors65 did not indicate the cause of deaths registered. Other authors attributed mortality to concomitant trauma and/or to systemic complications; many factors should be considered (polytrauma situation and ISS, and indirect blood loss and concomitant transfusions).3,82 Timing of TAE could be another important factor but we did not analyse it because very few studies reported mortality (or efficacy rate) with respect to timing of TAE.

Few studies provided data on angio-related complications. Complications should be divided in that of arterial access (haematoma, femoral artery arteriovenous fistula, pseudoaneurysm, etc) and of the artery affected (dissection, rupture, etc) and that are consequent of the embolization (infarction, necrosis, abscess, etc).

The latter were described in all districts; some of them may be easily managed; an example may be cholecystectomy after gallbladder infarction; others, like liver or splenic abscesses are more severe. In these patients, the initial extent of haemorrhagic damage should be considered before to attribute abscess, necrosis and organ failure (in the case of liver) to TAE. These data are not available but sometimes only deductible from the entity of trauma (when reported) and consequently it can not be trusted.

Non-target embolization was described only in a series of the (Table 2).27 Muscle necrosis was described in pelvic embolization, but it is unknown if another approach would have avoided this complication.

CONCLUSION

In conclusion, TAE seems to represent effective acute interventions for arterial haemorrhage control in the context of abdominopelvic trauma and could potentially reduce relevant mortality rates. Haemodynamic stabilization of the patient should be considered the main purpose of TAE.

The necessity of a subsequent surgical revision depends on several factors, in most cases not dependent on unsuccessful TAE, as the present review demonstrated. Only randomized control trials could confirm the data reported. Nevertheless, randomized trials are very difficult to perform in emergency settings.

REFERENCES

1 . Papakostidis C, , Kanakaris N, , Dimitriou R, , Giannoudis PV.. The role of arterial embolization in controlling pelvic fracture haemorrhage: a systematic review of the literature. Eur J Radiol 2012 ; 81: 897–904. doi: 10.1016/j.ejrad.2011.02.049 [PubMed] [Cross Ref]
2 . Niola R, , Pinto A, , Sparano A, , Ignarra R, , Romano L, , Maglione F.. Arterial bleeding in pelvic trauma: priorities in angiographic embolization. Curr Probl Diagn Radiol 2012 ; 41: 93–101. doi: 10.1067/j.cpradiol.2011.07.008 [PubMed] [Cross Ref]
3 . Ierardi AM, , Piacentino F, , Fontana F, , Petrillo M, , Floridi C, , Bacuzzi A., et al. . The role of endovascular treatment of pelvic fracture bleeding in emergency settings. Eur Radiol 2015 ; 25: 1854–64. doi: 10.1007/s00330-015-3589-3 [PubMed] [Cross Ref]
4 . Zealley IA, , Chakraverty S.. The role of interventional radiology in trauma. BMJ 2010 ; 340: 356–60. doi: 10.1136/bmj.c497 [PubMed] [Cross Ref]
5 . Nicodemo A, , Decaroli D, , Pallavicini J, , Sivieri R, , Aprato A, , Massè A.. A treatment protocol for abdomino-pelvic injuries. J Orthopaed Traumatol 2008 ; 9: 89–95. doi: 10.1007/s10195-008-0003-9 [PMC free article] [PubMed] [Cross Ref]
6 . Hoff WS, , Holevar M, , Nagy KK, , Patterson L, , Young JS, , Arrillaga A., et al. . East practice management guidelines work group: practice management guidelines for the evaluation of blunt abdominal trauma. J Trauma 2002 ; 53: 602–15. doi: 10.1097/00005373-200209000-00038 [PubMed] [Cross Ref]
7 . Stassen NA, , Bhullar I, , Cheng JD, , Crandall M, , Friese R, , Guillamondegui O., et al. . Nonoperative management of blunt hepatic injury: an Eastern Association for the Surgery of Trauma practice management guideline. J Trauma 2012 ; 73: S288–293. doi: 10.1097/TA.0b013e318270160d [PubMed] [Cross Ref]
8 . Requarth JA, , D'Agostino RB, Jr, , Miller PR.. Nonoperative management of adult blunt splenic injury with and without splenic artery embolotherapy: a meta-analysis. J Trauma 2011 ; 71: 898–903. doi: 10.1097/TA.0b013e318227ea50 [PubMed] [Cross Ref]
9 . Santucci RA, , Wessells H, , Bartsch G, , Descotes J, , Heyns CF, , McAninch JW., et al. . Evaluation and management of renal injuries: consensus statement of the renal trauma subcommittee. BJU Int 2004 ; 93: 937–54. doi: 10.1111/j.1464-4096.2004.04820.x [PubMed] [Cross Ref]
10 . Tinkoff G, , Esposito TJ, , Reed J, , Kilgo P, , Fildes J, , Pasquale M., et al. . American association for the surgery of trauma organ injury scale I: spleen, liver, and kidney, validation based on the National Trauma Data Bank. J Am Coll Surg 2008 ; 207: 646–55. [PubMed]
11 . Holden A.. Abdomen–interventions for solid organ injury. Injury 2008 ; 39: 1275–89. doi: 10.1016/j.injury.2008.04.019 [PubMed] [Cross Ref]
12 . Paffrath T, , Lefering R, , Flohé S, , TraumaRegister DG.. How to define severely injured patients?—an injury severity score (ISS) based approach alone is not sufficient. Injury 2014 ; 45(Suppl. 3): S64–9. doi: 10.1016/j.injury.2014.08.020 [PubMed] [Cross Ref]
13 . Kozar RA, , Moore JB, , Niles SE, , Holcomb JB, , Moore EE, , Cothren CC., et al. . Complications of nonoperative management of high-grade blunt hepatic injuries. J Trauma 2005 ; 59: 1066–71. doi: 10.1097/01.ta.0000188937.75879.ab [PubMed] [Cross Ref]
14 . Laopaiboon V, , Aphinives C, , Pongsuwan P, , Pugkem A, , Thammaroj J, , Puttharuk W.. Hepatic artery embolization to control liver hemorrhages by interventional radiologists: experiences from Khon Kaen University. J Med Assoc Thai 2006 ; 89: 384–9. [PubMed]
15 . Monnin V, , Sengel C, , Thony F, , Bricault I, , Voirin D, , Letoublon C., et al. . Place of arterial embolization in severe blunt hepatic trauma: a multidisciplinary approach. Cardiovasc Interv Radiol 2008 ; 31: 875–82. doi: 10.1007/s00270-007-9277-1 [PubMed] [Cross Ref]
16 . Misselbeck TS, , Teicher EJ, , Cipolle MD, , Pasquale MD, , Shah KT, , Dangleben DA., et al. . Hepatic angioembolization in trauma patients: indications and complications. J Trauma 2009 ; 67: 769–73. doi: 10.1097/TA.0b013e3181b5ce7f [PubMed] [Cross Ref]
17 . Letoublon C, , Morra I, , Chen Y, , Monnin V, , Voirin D, , Arvieux C.. Hepatic arterial embolization in the management of blunt hepatic trauma: indications and complications. J Trauma 2011 ; 70: 1032–6. doi: 10.1097/TA.0b013e31820e7ca1 [PubMed] [Cross Ref]
18 . Wang YC, , Fu CY, , Chen YF, , Hsieh CH, , Wu SC, , Yeh CC.. Role of arterial embolization on blunt hepatic trauma patients with type I contrast extravasation. Am J Emerg Med 2011 ; 29: 1147–51. doi: 10.1016/j.ajem.2010.06.001 [PubMed] [Cross Ref]
19 . Ochiai T, , Igari K, , Yagi M, , Ito H, , Kumagai Y, , Iida M., et al. . Treatment strategy for blunt hepatic trauma: analysis of 183 consecutive cases. Hepatogastroenterology 2011 ; 58: 1312–5. doi: 10.5754/hge11042 [PubMed] [Cross Ref]
20 . Mohan B, , Bhoday HS, , Aslam N, , Kaur H, , Chhabra S, , Sood N., Wander G Hepatic vascular injury: clinical profile, endovascular management and outcomes. Indian Heart J 2013 ; 65: 59–65. doi: 10.1016/j.ihj.2012.12.011 [PMC free article] [PubMed] [Cross Ref]
21 . Kong YL, , Zhang HY, , He XJ, , Zhao G, , Liu CL, , Xiao M., et al. . Angiographic embolization in the treatment of intrahepatic arterial bleeding in patients with blunt abdominal trauma. Hepatobiliary Pancreat Dis Int 2014 ; 13: 173–8. doi: 10.1016/S1499-3872(14)60027-8 [PubMed] [Cross Ref]
22 . Lee YH, , Wu CH, , Wang LJ, , Wong YC, , Chen HW, , Wang CJ., et al. . Predictive factors for early failure of transarterial embolization in blunt hepatic injury patients. Clin Radiol 2014 ; 69: e505–11. doi: 10.1016/j.crad.2014.08.013 [PubMed] [Cross Ref]
23 . Hagiwara A, , Murata A, , Matsuda T, , Matsuda H, , Shimazaki S.. The usefulness of transcatheter arterial embolization for patients with blunt polytrauma showing transient response to fluid resuscitation. J Trauma 2004 ; 57: 271–6. doi: 10.1097/01.TA.0000131198.79153.3C [PubMed] [Cross Ref]
24 . Liu PP, , Lee WC, , Cheng YF, , Cheng YF, , Hsieh PM, , Hsieh YM., et al. . Use of splenic artery embolization as an adjunct to nonsurgical management of blunt splenic injury. J Trauma 2004 ; 56: 768–772. doi: 10.1097/01.TA.0000129646.14777.ff [PubMed] [Cross Ref]
25 . Dent D, , Alsabrook G, , Erickson BA, , Myers J, , Wholey M, , Stewart R., et al. . Blunt splenic injuries: high nonoperative management rate can be achieved with selective embolization. J Trauma 2004 ; 56: 1063–7. doi: 10.1097/01.TA.0000123037.66867.F2 [PubMed] [Cross Ref]
26 . Wahl WL, , Ahrns KS, , Chen S, , Hemmila MR, , Rowe SA, , Arbabi S.. Blunt splenic injury: operation versus angiographic embolization. Surgery 2004 ; 136: 891–99. doi: 10.1016/j.surg.2004.06.026 [PubMed] [Cross Ref]
27 . Haan JM, , Bochicchio GV, , Kramer N, , Scalea TM.. Nonoperative management of blunt splenic injury: a 5-year experience. J Trauma 2005 ; 58: 492–98. doi: 10.1097/01.TA.0000154575.49388.74 [PubMed] [Cross Ref]
28 . Bessoud B, , Denys A, , Calmes JM, , Madoff D, , Qanadli S, , Schnyder P., et al. . Nonoperative management of traumatic splenic injuries: is there a role for proximal splenic artery embolization? AJR Am J Roentgenol 2006 ; 186: 779–85. doi: 10.2214/AJR.04.1800 [PubMed] [Cross Ref]
29 . Cooney R, , Ku J, , Cherry R, , Maish GO, III, , Carney D, , Scorza LB., et al. . Limitations of splenic angioembolization in treating blunt splenic injury. J Trauma 2005 ; 59: 926–32. doi: 10.1097/01.ta.0000188134.32106.89 [PubMed] [Cross Ref]
30 . Smith HE, , Biffl WL, , Majercik SD, , Jednacz J, , Lambiase R, , Cioffi WG.. Splenic artery embolization: have we gone too far? J Trauma 2006 ; 61: 541–4; discussion 545–546. doi: 10.1097/01.ta.0000235920.92385.2b [PubMed] [Cross Ref]
31 . Gaarder C, , Dormagen JB, , Eken T, , Skaga NO, , Klow NE, , Pillgram-Larsen J., et al. . Nonoperative management of splenic injuries: improved results with angioembolization. J Trauma 2006 ; 61: 192–8. doi: 10.1097/01.ta.0000223466.62589.d9 [PubMed] [Cross Ref]
32 . Haan JM, , Marmery H, , Shanmuganathan K, , Mirvis SE, , Scalea TM.. Experience with splenic main coil embolization and significance of new or persistent pseudoaneurym: reembolize, operate, or observe. J Trauma 2007 ; 63: 615–19. doi: 10.1097/TA.0b013e318142d244 [PubMed] [Cross Ref]
33 . Wei B, , Hemmila MR, , Arbabi S, , Taheri PA, , Wahl WL.. Angioembolization reduces operative intervention for blunt splenic injury. J Trauma 2008 ; 64: 1472–7. doi: 10.1097/TA.0b013e318174e8cd [PubMed] [Cross Ref]
34 . Duchesne JC, , Simmons JD, , Schmieg RE, Jr, , McSwain NE, Jr, , Bellows CF.. Proximal splenic angioembolization does not improve outcomes in treating blunt splenic injuries compared with splenectomy: a cohort analysis. J Trauma 2008 ; 65: 1346–51. doi: 10.1097/TA.0b013e31818c29ea [PubMed] [Cross Ref]
35 . Widlus DM, , Moeslein FM, , Richard HM., III. Evaluation of the Amplatzer vascular plug for proximal splenic artery embolization. J Vasc Interv Radiol 2008 ; 19: 652–56. doi: 10.1016/j.jvir.2007.11.025 [PubMed] [Cross Ref]
36 . Wu SC, , Chen RJ, , Yang AD, , Tung CC, , Lee KH.. Complications associated with embolization in the treatment of blunt splenic injury. World J Surg 2008 ; 32: 476–82. doi: 10.1007/s00268-007-9322-x [PubMed] [Cross Ref]
37 . Kaseje N, , Agarwal S, , Burch M, , Giantz A, , Emhoff T, , Burke P., et al. . Short-term outcomes of splenectomy avoidance in trauma patients. Am J Surg 2008 ; 196: 213–17. doi: 10.1016/j.amjsurg.2007.07.037 [PubMed] [Cross Ref]
38 . Sabe AA, , Claridge JA, , Rosenblum DI, , Lie K, , Malangoni MA.. The effects of splenic artery embolization on nonoperative management of blunt splenic injury: a 16-year experience. J Trauma 2009 ; 67: 565–72. doi: 10.1097/TA.0b013e3181b17010 [PubMed] [Cross Ref]
39 . Ekeh AP, , Izu B, , Ryan M, , McCarthy MC.. The impact of splenic artery embolization on the management of splenic trauma: an 8-year review. Am J Surg 2009 ; 197: 337–41. doi: 10.1016/j.amjsurg.2008.11.017 [PubMed] [Cross Ref]
40 . Franco F, , Monaco D, , Volpi A, , Marcato C, , Larini P, , Rossi C.. The role of arterial embolization in blunt splenic injury. Radiol Med 2011 ; 116: 454–65. doi: 10.1007/s11547-011-0624-y [PubMed] [Cross Ref]
41 . Chen IC, , Wang SC, , Shih HC, , Wang CY, , Liu CC, , Wen YS., et al. . Spleen artery embolization increases the success of nonoperative management following blunt splenic injury. J Chin Med Assoc 2011 ; 74: 341–4. doi: 10.1016/j.jcma.2011.06.005 [PubMed] [Cross Ref]
42 . Rosati C, , Ata A, , Siskin GP, , Megna D, , Bonville DJ, , Stain SC.. Management of splenic trauma: a single institution's 8-year experience. Am J Surg 2015 ; 209: 308–14. doi: 10.1016/j.amjsurg.2014.06.034 [PubMed] [Cross Ref]
43 . Beuran M, , Gheju I, , Venter MD, , Marian RC, , Smarandache R.. Non operative management of splenic trauma. J Med Life 2012 ; 5: 47–58. [PMC free article] [PubMed]
44 . Dinkel HP, , Danuser H, , Triller J.. Blunt renal trauma minimally invasive management with microcatheter embolization experience in nine patients. Radiology 2002 ; 223: 723–30. [PubMed]
45 . Chatziioannou A, , Brountzos E, , Primetis E, , Malagari K, , Sofocleous C, , Mourikis D., et al. . Effects of superselective embolization for renal vascular injuries on renal parenchyma and function. Eur J Vasc Endovasc Surg 2004 ; 28: 201–6. doi: 10.1016/j.ejvs.2004.05.003 [PubMed] [Cross Ref]
46 . Sofocleous CT, , Hinrichs C, , Hubbi B, , Brountzos E, , Kaul S, , Kannarkat G., et al. . Angiographic findings and embolotherapy in renal arterial trauma. Cardiovasc Intervent Radiol 2005 ; 28: 39–47. doi: 10.1007/s00270-004-0042-4 [PubMed] [Cross Ref]
47 . Nicola M, , Gulfi G, , Pea U, , Bozzola A, , De Luca F, , Seregni R., et al. . Renal artery embolization for kidney trauma. Arch Ital Urol Androl 2007 ; 79: N4. [PubMed]
48 . Breyer BN, , McAninch JW, , Elliott SP, , Master VA.. Minimally invasive endovascular techniques to treat acute renal hemorrhage. J Urol 2008 ; 179: 2248–53. doi: 10.1016/j.juro.2008.01.104 [PubMed] [Cross Ref]
49 . Mohsen T, , El-Assmy A, , El-Diasty T.. Long-term functional and morphological effects of transcatheter arterial embolization of traumatic renal vascular injury. BJU Int 2008 ; 101: 473–7. [PubMed]
50 . Chow SJ, , Thompson KJ, , Hartman JF, , Wright ML.. A 10-year review of blunt renal artery injuries at an urban level I trauma centre. Injury 2009 ; 40: 844–50. doi: 10.1016/j.injury.2008.11.022 [PubMed] [Cross Ref]
51 . Morita S, , Inokuchi S, , Tsuji T, , Fukushima T, , Higami S, , Yamagiwa T., et al. . Arterial embolization in patients with grade-4 blunt renal trauma: evaluation of the glomerular filtration rates by dynamic scintigraphy with 99mTechnetium-diethylene triamine pentacetic acid. Scand J Trauma Resusc Emerg Med 2010 ; 18: 11. doi: 10.1186/1757-7241-18-11 [PMC free article] [PubMed] [Cross Ref]
52 . Kiankhooy A, , Sartorelli KH, , Vane DW, , Bhave AD.. Angiographic embolization is safe and effective therapy for blunt abdominal solid organ injury in children. J Trauma 2010 ; 68: 526–31. [PubMed]
53 . Eassa W, , El-Ghar MA, , Jednak R, , El-Sherbiny M.. Nonoperative management of grade 5 renal injury in children: does it have a place? Eur Urol 2010 ; 57: 154–61. doi: 10.1016/j.eururo.2009.02.001 [PubMed] [Cross Ref]
54 . Brewer ME, Jr, , Strnad BT, , Daley BJ, , Currier RP, , Klein FA, , Mobley JD., et al. . Percutaneous embolization management grade 5 renal trauma hemodynamically unstable patients: initial experience. J Urol 2009 ; 181: 1737–41. [PubMed]
55 . Menaker J, , Joseph B, , Stein DM, , Scalea TM.. Angiointervention: high rates of failure following blunt renal injuries. World J Surg 2011 ; 35: 520–7. doi: 10.1007/s00268-010-0927-0 [PubMed] [Cross Ref]
56 . Müller-Wille R, , Heiss P, , Herold T, , Jung EM, , Schreyer AG, , Hamer OW., et al. . Endovascular Treat Acute Arterial Hemorrhage Trauma Patients Using Ethylene Vinyl Alcohol Copolymer (onyx). Cardiovasc Intervent Radiol 2012 ; 35: 65–75. [PubMed]
57 . Hotaling JM, , Sorensen MD, , Smith TG, III, , Rivara FP, , Wessells H., Voelzke BB Analysis of Diagnostic Angiography and Angioembolization in the Acute Management of Renal Trauma Using a National Data Set. J Urol 2011 ; 185: 1316–20. doi: 10.1016/j.juro.2010.12.003 [PMC free article] [PubMed] [Cross Ref]
58 . van der Vlies CH, , Olthof DC, , van Delden OM, , Ponsen KJ, , de la Rosette JJ, , de Reijke TM., et al. . Management of blunt renal injury in a level 1 trauma centre in view of the European guidelines. Injury 2012 ; 43: 1816–20. doi: 10.1016/j.injury.2011.06.034 [PubMed] [Cross Ref]
59 . Lin WC, , Lin CH, , Chen JH, , Chen YF, , Chang CH, , Wu SC., et al. . Computed tomographic imaging in determining the need of embolization for high-grade blunt renal injury. J Trauma Acute Care Surg 2013 ; 74: 230–5. doi: 10.1097/TA.0b013e318270e156 [PubMed] [Cross Ref]
60 . van der Wilden GM, , Velmahos GC, , Joseph DK, , Jacobs L, , Debusk MG, , Adams CA., et al. . Successful nonoperative management of the most severe blunt renal injuries: a multicenter study of the research consortium of New England Centers for Trauma. JAMA Surg 2013 ; 148: 924–31. doi: 10.1001/jamasurg.2013.2747 [PubMed] [Cross Ref]
61 . Saour M, , Charbit J, , Millet I, , Monnin V, , Taourel P, , Klouche K., et al. Effect of renal angioembolization on post-traumatic acute kidney injury after high-grade renal trauma: A comparative study of 52 consecutive cases Injury, Int J Care Injured 2014 ; 45: 894–901. doi: 10.1016/j.injury.2013.11.030 [PubMed] [Cross Ref]
62 . Rao D, , Yu H, , Zhu H, , Yu K, , Hu X, , Xie L.. Superselective transcatheter renal artery embolization for the treatment of hemorrhage from non-iatrogenic blunt renal trauma: report of 16 clinical cases. Ther Clin Risk Manag 2014 ; 10: 455–8. [PMC free article] [PubMed]
63 . An T, , Zhang S, , Xu M, , Zhou S, , Wang W.. Transcatheter embolization of peripheral renal artery for hemorrhagic urological emergencies using FuAiLe medical glue. Sci Rep 2015 ; 5: 9106. doi: 10.1038/srep09106 [PMC free article] [PubMed] [Cross Ref]
64 . Sofocleous CT, , Hinrichs CR, , Hubbi B, , Doddakashi S, , Bahramipour P, , Schubert J.. Embolization of isolated lumbar artery injuries in trauma patients. Cardiovasc Intervent Radiol 2005 ; 28: 730–5. doi: 10.1007/s00270-003-0117-7 [PubMed] [Cross Ref]
65 . Sarin EL, , Moore JB, , Moore EE, , Shannon MR, , Ray CE, , Morgan SJ., et al. . Pelvic fracture pattern does not always predict the need for urgent embolization. J Trauma 2005 ; 58: 973–7. doi: 10.1097/01.TA.0000171985.33322.b4 [PubMed] [Cross Ref]
66 . Fangio P, , Asehnoune K, , Edouard A, , Smail N, , Benhamou D.. Early embolization and vasopressor administration for management of life-threatening hemorrhage from pelvic fracture. J Trauma 2005 ; 58: 978–84; discussion 984. doi: 10.1097/01.TA.0000163435.39881.26 [PubMed] [Cross Ref]
67 . Shapiro M, , McDonald AA, , Knight D, , Johannigman JA, , Cuschieri J.. The role of repeat angiography in the management of pelvic fractures. J Trauma 2005 ; 58: 227–31. doi: 10.1097/01.TA.0000152080.97337.1F [PubMed] [Cross Ref]
68 . Sadri H, , Nguyen-Tang T, , Stern R, , Hoffmeyer P, , Peter R.. Control of severe hemorrhage using C-clamp and arterial embolization in hemodynamically unstable patients with pelvic ring disruption. Arch Orthop Trauma Surg 2005 ; 125: 443–7. doi: 10.1007/s00402-005-0821-7 [PubMed] [Cross Ref]
69 . Tötterman A, , Dormagen JB, , Madsen JE, , Kløw NE, , Skaga NO, , Røise O.. A protocol for angiographic embolization in exsanguinating pelvic trauma: a report on 31 patients. Acta Orthopaedica 2006 ; 77: 462–8. doi: 10.1080/17453670610046406 [PubMed] [Cross Ref]
70 . Akpinar E, , Peynircioglu B, , Turkbey B, , Cil BE, , Balkanci F.. Endovascular management of life-threatening retroperitoneal bleeding. ANZ J Surg 2008 ; 78: 683–7. doi: 10.1111/j.1445-2197.2008.04148.x [PubMed] [Cross Ref]
71 . Verbeek DO, , Sugrue M, , Balogh Z, , Cass D, , Civil I, , Harris I., et al. . Acute management of hemodynamically unstable pelvic trauma patients: time for a change? Multicenter review of recent practice. World J Surg 2008 ; 32: 1874–82. doi: 10.1007/s00268-008-9591-z [PubMed] [Cross Ref]
72 . Fang JF, , Shih LY, , Wong YC, , Lin BC, , Hsu YP.. Repeat transcatheter arterial embolization for the management of pelvic arterial hemorrhage. J Trauma 2009 ; 66: 429–35. doi: 10.1097/TA.0b013e31817c969b [PubMed] [Cross Ref]
73 . Jeske HC, , Larndorfer R, , Krappinger D, , Attal R, , Klingensmith M, , Lottersberger C., et al. . Management of hemorrhage in severe pelvic injuries. J Trauma 2010 ; 68: 415–20. doi: 10.1097/TA.0b013e3181b0d56e [PubMed] [Cross Ref]
74 . Hauschild O, , Aghayev E, , von Heyden J, , Strohm PC, , Culemann U, , Pohlemann T., et al. . Angioembolization for pelvic hemorrhage control: results from the German pelvic injury register. J Trauma Acute Care Surg 2012 ; 73: 679–84. doi: 10.1097/TA.0b013e318253b5ba [PubMed] [Cross Ref]
75 . Fu CY, , Hsieh CH, , Wu SC, , Chen RJ, , Wang YC, , Shih CH., et al. . Anterior-posterior compression pelvic fracture increases the probability of requirement of bilateral embolization. Am J Emerg Med 2013 ; 31: 42–9. doi: 10.1016/j.ajem.2012.05.026 [PubMed] [Cross Ref]
76 . Chakraverty S, , Flood K, , Kessel D, , McPherson S, , Nicholson T, , Ray CE., Jr, et al. . CIRSE guidelines: quality improvement guidelines for endovascular treatment of traumatic hemorrhage. Cardiovasc Intervent Radiol 2012 ; 35: 472–82. doi: 10.1007/s00270-012-0339-7 [PubMed] [Cross Ref]
77 . Roudsari BS, , Psoter KJ, , Padia SA, , Kogut MJ, , Kwan SW.. Utilization of angiography and embolization for abdominopelvic trauma: 14 years' experience at a level I trauma center. AJR Am J Roentgenol 2014 ; 202: W580–5. doi: 10.2214/AJR.13.11216 [PMC free article] [PubMed] [Cross Ref]
78 . Cullinane DC, , Schiller HJ, , Zielinski MD, , Bilaniuk JW, , Collier BR, , Como J., et al. . Eastern Association for the Surgery of Trauma practice management guidelines for hemorrhage in pelvic fracture—update and systematic review. J Trauma 2011 ; 71: 1850–68. doi: 10.1097/TA.0b013e31823dca9a [PubMed] [Cross Ref]
79 . Stassen NA, , Bhullar I, , Cheng JD, , Crandall ML, , Friese RS, , Guillamondegui OD., et al. . Eastern Association for the Surgery of Trauma. Selective nonoperative management of blunt splenic injury: an Eastern Association for the Surgery of Trauma practice management guideline. J Trauma Acute Care Surg 2012 ; 73(5 Suppl. 4): S294–300. doi: 10.1097/TA.0b013e3182702afc [PubMed] [Cross Ref]
80 . Raikhlin A, , Baerlocher MO, , Asch MR, , Myers A.. Imaging transcatheter arterial embolization for traumatic splenic injuries: review literature. Can J Surg 2008 ; 51: 464–72. [PMC free article] [PubMed]
81 . Lynch TH, , Martínez-Piñeiro L, , Plas E, , Serafetinides E, , Tü rkeri L, , Santucci RA., et al. . EAU guidelines on urological trauma. Eur Urol 2005 ; 47: 1–15. [European Association of Urology Guidelines onUrological Trauma (online). http://www.uroweb.org; 2009. doi: 10.1016/j.eururo.2004.07.028 [PubMed] [Cross Ref]
82 . Silverboard H, , Aisiku I, , Martin GS, , Adams M, , Rozycki G, , Moss M.. The role of acute blood transfusion in the development of acute respiratory distress syndrome in patients with severe trauma. J Trauma 2005 ; 59: 717–23. [PubMed]

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