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J Clin Pathol. 1983 May; 36(5): 515–518.
PMCID: PMC498277

Angiosarcoma developing around a foreign body.


An 86-year-old World War I veteran developed an angiosarcoma at the site of a war wound. The tumour developed in relation to one of several metal grenade fragments. The tumour cells have been shown to contain blood coagulation factor VIII antigen and have features of endothelial cells on electron microscopy. The patient is claimed to be the last soldier dying of wounds sustained during that war, and to have the longest disease-free interval between injury and the onset of complications.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Hoyer LW, De los Santos RP, Hoyer JR. Antihemophilic factor antigen. Localization in endothelial cells by immunofluorescent microscopy. J Clin Invest. 1973 Nov;52(11):2737–2744. [PMC free article] [PubMed]
  • Jaffe EA, Hoyer LW, Nachman RL. Synthesis of antihemophilic factor antigen by cultured human endothelial cells. J Clin Invest. 1973 Nov;52(11):2757–2764. [PMC free article] [PubMed]
  • Rosai J, Sumner HW, Kostianovsky M, Perez-Mesa C. Angiosarcoma of the skin. A clinicopathologic and fine structural study. Hum Pathol. 1976 Jan;7(1):83–109. [PubMed]
  • WEIBEL ER, PALADE GE. NEW CYTOPLASMIC COMPONENTS IN ARTERIAL ENDOTHELIA. J Cell Biol. 1964 Oct;23:101–112. [PMC free article] [PubMed]
  • Brand KG, Johnson KH, Buoen LC. Foreign body tumorigenesis. CRC Crit Rev Toxicol. 1976 Oct;4(4):353–394. [PubMed]
  • Fehrenbacher JW, Bowers W, Strate R, Pittman J. Angiosarcoma of the aorta associated with a Dacron graft. Ann Thorac Surg. 1981 Sep;32(3):297–301. [PubMed]
  • Dawson EK, McIntosh D. Granulation tissue sarcoma following long-standing varicose ulceration. J R Coll Surg Edinb. 1971 Mar;16(2):88–95. [PubMed]
  • Knox J, Wilkinson A. Shrapnel presenting with symptoms 62 years after wounding. Br Med J (Clin Res Ed) 1981 Jul 18;283(6285):193–193. [PMC free article] [PubMed]

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