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MAbs. 2016 July; 8(5): 841–847.
Published online 2016 April 26. doi:  10.1080/19420862.2016.1180491
PMCID: PMC4968089

Extending the market exclusivity of therapeutic antibodies through dosage patents

ABSTRACT

Dosage patents are one way to extend the market exclusivity of an approved drug beyond the lifetime of the patent that protects the drug as such. Dosage patents may help to compensate the applicant for the long period where the active pharmaceutical ingredient as such is already under patent prosecution, but not on the market yet, due to lengthy development and approval procedures. This situation erodes part of the time the drug is marketed under patent protection. Dosage patents filed at a later date can provide remedy for this problem. Examples of successful and unsuccesful attempts, and the reasons for the respective outcomes, are provided in this article.

KEYWORDS: Dosage, fractionation, inventive step, patent, rituximab, trastuzumab

Introduction

The rationale of granting a patent on a new dosage regimen for a given drug is that the development of such dosage regimen needs to balance patient compliance, therapeutic efficacy and side effects of said drug - a goal not always easily attained, hence requiring substantial skills. The role of dosage patents in the protection of therapeutic antibodies is substantial. However, in Europe, dosage patents have been in a rather gray area until 2008, mainly because they were considered to qualify as non-patent eligible methods of treatment. In decision T0317/95,1 a claim devoted to the combination of a bismuth-containing agent and an H2-receptor blocking agent was at stake, in which the administration of the said 2 agents was effected within 5 minutes of each other. The Board of Appeal found that

“determination of the best individual treatment schedule, in particular the prescribing and modification of drug regimens used for administering a particular medicament (…), appear to be in the first place part of the typical activities and duties of the doctor in attendance in exercising his professional skills”

These, the Board contined, were typical non-commercial and non-industrial medical activities that the EPC would intend to free from restraint under the method of treatment exemption.

In decision T0056/97,2 the same Board of Appeal had to decide about a claim devoted to the use of a thiazide diuretic having a predetermined diuretic effective dose, wherein a dosage unit was established that was 7–25% by weight of the predetermined diuretic effective dose. The Board rejected the claim for the same reasons as in T0317/95, and emphasized that it had

“difficulty in seeing claim 1 as more than an unsuccessful attempt to obtain protection for a method of therapeutic treatment of the human or animal body”

It appears that these decisions relied on the assumption that dosage finding was something a medical practitioner would do in his daily practice. Obviously, these decisions ignored that a suitable dosage is today found in a clinical trial that forms part of the approval process, requires substantial input of intellectual and financial resources of different parties, and is not within the routine of a medical practitioner.

Decision G2/08 – when it all became official

In decision G2/08, which issued February 9, 2010, the Enlarged Board of Appeal (EBA) of the European Patent Office (EPO) reversed this policy, and declared dosage regimen claims to be principally admissible:3

“Where it is already known to use a medicament to treat an illness, Article 54(5) EPC does not exclude that this medicament be patented for use in a different treatment by therapy of the same illness. Such patenting is also not excluded where a dosage regime is the only feature claimed which is not comprised in the state of the art.”

In an obiter dictum, the EBA also declared that they were aware that dosage regimen patents run a risk of being applied in an abusive fashion:

“The EBA does not ignore the concerns with respect to undue prolongations of patent rights potentially resulting from patent protection for claims purporting to derive their novelty and inventive step only from a not hitherto so defined dosage regime (…).”

Hence, the EBA made clear that patent claims on dosage regimens need to be examined with the same scrutiny toward novelty and inventive step as other patent claims:

“Therefore, it is important to stress that (…) for the assessment of novelty and inventive step of a claim in which the only novel feature would be the dosage regime, the whole body of jurisprudence relating to the assessment of novelty and inventive step generally also applies.”

In other words, one will not receive a patent on a dosage regimen that is obvious in view of the existing prior art, or not sufficiently enabled or disclosed in the respective application, as will be discussed in the following sections.

Practical relevance of dosage patents

On paper, a dosage patent may appear narrow and easy to bypass because its claims comprise a very specific dosage restriction, variation of which would draw an alternative dosage regimen out the literal scope of the claim. Further, some jurisdictions have high demands as regards a potential scope of equivalence. German courts, for example, have established a position according to which claimed ranges defined by numercial values leave no scope of equivalence. In a decision of March 12, 2002, the Federal Supreme Court stated the following: 4

“For a skilled reader, features concretized by numerical values can have the meaning that the technical object of the invention is to be defined more precesiely and, where appropriate, narrowly than would be the case for a mere verbal definition. As it is the applicant's responsibility to ensure that everything for which protection is sought is recited in the patent claim, the reader of the patent specification is entitled to assume that this principle has been been satisfied through the inclusion of numercial values in the claim language. This is all the more the case because an applicant, when using numercial values, has the chance to clearly consider the consequences of the chosen claim language onf the scope oft he protection sought for.”

Translated to dosage regimen claims, this means that, once a potential infringer modifies a claimed dosage in such way that it is just outside the claimed range, German courts would deny an infringement even under the scope of equivalence.

Notwithstanding the above drawbacks, dosage patents have an effect because they oftentimes receive substantial power from a corresponding marketing authorization. European Directive 2001/83/EC requires, under Art 11, that the Summary of Product Charateristics (SoPC) contains, inter alia, information as to posology (=dosage), composition (=formulation) and indication of the authorized drug.

Biosimilar manufacturers rely preferably on the authorized dosage of a branded drug because they usually do not want to establish their own dosage regimen, as this would require a completely new authorization process. If, however, the dosage for which the drug is approved is the subject of a patent, then using said dosage for the biosimilar (e.g., mentioning it in the Biosimilar SoPC) would qualify as a patent infringement. This, in turn, explains the prolonging effect dosage patents can have on the overall exclusivity of an approved antibody. Table 1 shows selected antibody dosage patents or patent applications that reflect the approved dosage.

Table 1.
Selected antibody dosage patents or patent applications that reflect the approved dosage.

Carve out/skinny labeling

European Directive 2001/83/EC provides a loophole in that, under Art 11, generic manufacturers need not include those parts of the SoPC which are still covered by patents at the time when the generic medicine was marketed. The clause is meant as an attempt to incentivize the development of generics and biosimilars. In the United States, 21 USC § 355 j (2)A (viiii) has a similar provision. This so-called carve-out solution can help biosimilar manufacturers to avoid infringement of dosage patents, when there is already a dosage in the SoPC that is not patent protected. It is, however, unclear what happens if the patented dosage is the only dosage in the SoPC. Can a biosimilar manufacturer exclude the dosage information in such case? This would mean that the SoPC has no dosage instruction whatsoever. For safety considerations, it seems this would be inacceptable. However, caselaw does not provide any clue to solve this issue.

Examples of dosage patents that failed in prosecution, or did not stand third party attacks

Case EP1616572B1 (Rituximab): Discrepancy between the dosage that is disclosed in the patent application as originally filed, and the dosage that eventually makes it into the label

European patent EP1616572B1, assigned to Biogen Idec, claimed the use of an escalated dosage regimen of the anti-CD20 antibody rituximab (Rituxan®/MabThera®) in chronic lymphocytic leukemia (CLL; see Table 1). Claim 1 was amended several times during prosecution, and was eventually granted as follows:

“Use of rituximab […] for treatment of CLL […], wherein the medicament is for administration […] at a first dose of 375 mg/m2 and subsequent dosage of 500 to 1500 mg/m2

The granted claim was drafted in such way to faithfully reflect the dosage recommendation in the label of the European Medicines Agency (EMA), which read 375 mg/m2 on day 0, followed by 500 mg/m2 (6 cycles). For treating CLL, rituximab is given in combination with chemotherapy, which is usually given every 4 weeks.5 To optimize patient compliance, rituximab administration is therefore adopted to that schedule.

However, the original disclosure in the patent specification (example 3) on which the amended claim relies was as follows:

“All patients receive a first dose of 375 mg/m3 to minimize infusion-relapsed side effects. Subsequent weekly dosages (3) remain the same but are given at an increased dose level […] of 500 –1500 mg/m3

The point that the specification used the unity “mg/m3” instead of “mg/m2,” as eventually claimed, was considered an obvious error by the Examining Division, who admitted a respective correction (a position which later was confirmed by the Opposition Division). More importantly, however, the dosage disclosed in example 3 of the patent specification had weekly intervals, and only for the specific combination of dosage and intervals was a therapeutic effect shown. In the claims that were granted eventually, the patent proprietor had omitted the interval completely because the dosage recommendation in the label was not restricted to such weekly intervals. Therefore, a claim with weekly intervals would have left numerous bypass solutions for biosimilar manufacturers, who in such case could have relied upon the dosage recommended in the label without infringing the patent.

The patent was opposed by 7 parties. On September 2, 2013, it was revoked in the first instance for inadmissible amendments (Art 123 (2) EPC). The Opposition Division objected to the omission of “weekly” because it created new subject matter that was not disclosed in the application as filed, and for which no data had been provided as regards a potential effect. In fact, effects demonstrated for a given dosage regimen with weekly intervals cannot simply be extrapolated to a dosage regimen with triweekly, or unspecificed, intervals. Example 3 of the patent, which allegedly provided the disclosure for the claimed escalating dosage regimen had either (1) been drafted too narrow, or (2) the application was filed too early, when the patent proprietor did not know enough about a clinically useful dosage regimen yet. The patent proprietor's attempt to bring claims and approved dosage regimen into conformity was foredoomed.

US7727968 (gemtuzumab ozogamicin): Why an inventive dosage could not be protected

The following example demonstrates that even seemingly minor changes in a dosage regimen can have a tremendous effect, thus rebutting the prejudice that the finding of a suitable dosage regimen is a matter of mere routine.

Pfizer's gemtuzumab ozogamicin (Mylotarg®) is an antibody-drug conjugate (ADC) comprising an anti-CD33 antibody conjugated to a calicheamicin toxin. In the United States, the drug was approved in 2000 for use in patients aged 60 or older with relapsed acute myelogenous leukemia (AML), with a recommended induction dose of 9 mg/m,2 on days 1 and 14. The corresponding dosage patent US7727968B2 was granted June 1, 2010, and is shown in Table 2.

Table 2.
Correlation between antibody dosage patent and approved dosage of gemtuzumab ozogamicin. The patent is broader than the approved dosage, hence anticipating later factionated dosages that could have given rise to new patent protection.

Upon request of the US Food and Drug Administration (FDA,) the drug was withdrawn in 2010 from the US market for lack of efficacy and an increase in number of fatal toxicities. Interestingly, the EMA had refused marketing authorization in 2008 because no randomized controlled trials were provided, while in Japan, the drug was approved as an orphan drug in 2005, and the Japanese authority decided to leave it on the market even after the 2010 withdrawal in the United States, provided that post-marketing surveillance was increased.6 Pfizer allowed the US patent to expire by non-payment of maintenance fees, without leaving any divisionals or continuation applications behind. Counterparts in other jurisdictions do not exist.

In 2009, French researcher Sylvie Castaigne and colleagues of the Acute Leukemia French Association began a study (ALFA-0701, NCT00927498) cosponsored by Central Hospital, Versailles, which involved 280 patients between 50 and 70 y of age with previously untreated AML. To minimize the toxic side effects, the team used a fractionated dosage approach with 3 mg/m2 on days 1, 4, and 7 during induction, and then another dose on day 1 on each of the 2 consolidation chemotherapy courses. Hence, the team merely subivided the FDA dosage into 3 fractions and shortened the intervals accordingly.

The results reported in 2012 revealed that, under the new dosage regimen, gemtuzumab ozogamicin actually improves overall survival in AML when added to standard chemotherapy, without an increase in the risk of death from toxicity.7 The results are consistent with those from another trial, which involved 1113 patients with de novo AML.8 Soon after publication of these results, several authors discussed the possibility of overturning the decision to withdraw gemtuzumab ozogamicin from the market.9 Reportedly, Pfizer also considered if “there is a plausible argument that the drug has benefit at an acceptable rate of toxicity.”10 However, no new approval has been obtained so far.

Unfortunately, the 3 mg/m2 dosage used by the group of Castaigne was already anticipated by Pfizer's surrendered patent US7727968B2, while the timing seems to be novel over that prior art reference. The modifications the team made to the established dosage regimen had a tremendous increase in efficacy, while toxicity was not affected, a result that was undoubtedly surprising for all parties involved. In discussions with a patent examiner, the term “surprising” is often used as a buzzword to argue in support of non-obviousness. For this reason, it appears that a patent application with claims reciting that specific dosage regimen would likely have been considered non-obvious. However, a patent search carried out by the author of this article did not reveal any respective patent applications. It appears that the team of Castaigne did not file a patent application prior to publishing their surprising results, nor did Pfizer, although Castaigne's research was partly funded by Pfizer.11

Case EP1210115B1 (Trastuzumab): Obviousness of a novel dosage regimen in view of a prior art dosage regimen

European patent EP1210115B1 related to a particular dosage regimen of the anti-human epidermal growth factor receptor (HER)2 antibody trastuzumab (Herceptin®), with 8 mg/kg loading dose and 6 mg/kg triweekly follow-up doses. The patent was opposed before the EPO by 6 opponents, and revoked on March 19, 2012 for lack of inventive step, in view of the published FDA-approved treatment regimen of a 4 mg/kg loading dose and subsequent 2 mg/kg weekly doses (see Table 3). The case is currently under appeal.

Table 3.
Dosage claimed in EP1210115B1 vis-a-vis prior art.

The UK part of the European patent was finally revoked on February 6, 2015 upon motion of generic company Hospira, who were also involved in the corresponding EP opposition. Like the Opposition Division of the EPO, the Courts found that the claimed treatment regimen was obvious over the published FDA-approved treatment.

In the first instance decision at the Patents Court,12 Justice Birss stated that a “clinician would consult with the pharmacokinetics expert and decide to go ahead with a trial of a 3-weekly dosing schedule and select the claimed doses.” In the second instance decision at the Court of Appeal,13 Justice Floyd went even further, in stating that “pharmacokinetics was not a field that was slavish to calculations and that clinical variability meant that such dosage regimens were always likely to fall within a range.” The latter statements are certainly oversimplifying the art of developing and establishing a dosage regimen that carefully weighs up patient compliance, therapeutic efficacy and side effects. Still, the ruling may generally affect the validity of dosage patents, in particular when prior art exists that discloses an earlier dosage regimen roughly similar to the claimed regimen. It is, however, not necessarily relevant for dosage patents that refer to the first dosage of an active ingredient, i.e., where there is no prior art benchmark to compete with in terms of non-obviousness.

Strategies to successfully prosecute dosage regimen patents

EP1616572B1 (Rituximab): Interplay of a new dosage and a new indication

As discussed above, the escalated rituximab dosage regimen claimed in EP1616572B1 was specifically meant for the treatment of CLL. Rituximab binds to CD20 positive cells, including lymphocytes and leukocytes. Because leukocytes are freely floating in the bloodstream, a rituximab infusion will lead to a quick onset of the cytotoxic effect on these leukocytes, by evoking antibody-dependent cell-mediated cytotoxicity (ADCC). In CLL patients with a high white blood cell count, rituximab treatment can cause severe side effcts due to mass lysis of leukocytes and a subsequent cytokine storm. The claimed escalated dosage regimen was thus meant to avoid these side effects by using a lower upfront doses, followed by higher doses to ensure sustainability of the response.

Compared to the standard dosage of rituximab, the new dosage regimen was alleged to have particular advantages with respect to this specific indication. Under more favorable circumstances, an applicant could have tried to use such dosage–indication relationship as an argument in support of non-obviousness. In the opposition hearing, these questions were, however, not discussed because all claims on file were found invalid for inadmissible added matter already, a ground that is usually discusssed before the inventive step. The appeal proceedings are ongoing.

EP2459167B1 (Trastuzumab): Interplay of a new dosage and a new mode of administration

Roche's trastuzumab received a further EMA approval on 2 September 2013 for subcutanous administration in the treatment of HER2-positive breast cancer. The recommended dose is 600 mg irrespective of the patient's body weight, administered in a 5 ml dose (hence, the administered concentration is 120 mg/ml) subcutaneously over 2–5 minutes every 3 weeks. Roche claims that, while for intravenous administration patients attend a hospital or clinic and each infusion takes 30–90 minutes to administer, the new subcutaneous formulation takes only 2–5 minutes to administer.14

On May 15, 2013, Roche received patent EP2459167B1, the priority date of which is July 31, 2009. The patent claim is a hybrid of dosage and formulation, and includes a recombinant hyaluronidase, which forms hyaluronan, a gel-like substance that creates a barrier between cells under the skin after injection.15 This, Roche claims, allows the 5 ml volume of the subcutaneous formulation of the drug to be rapidly dispersed and absorbed over a greater area.

The patent is subject to an opposition by an undisclosed party, but was maintained in the first instance with the following claims 1 and 3:

1. A liquid, highly concentrated, stable pharmaceutical formulation of a pharmaceutically active anti-HER2 antibody for subcutaneous injection comprising:

a. about 50 to 350 mg/ml anti-HER2 antibody;

(…)

e. more than 150 to about 16,000 U/ml, about 2,000 U/ml, or about 12,000 U/ml, respectively, of a hyaluronidase enzyme.

3. A highly concentrated, stable pharmaceutical anti-HER2 antibody formulation according to claim 1 or claim 2, wherein the anti-HER2 antibody concentration is (…) 120 ± 18 mg/ml (…)

The present example again shows the close match between the approved and the claimed dosage and how regulatory aspects and aspects of Intellectual property are intertwined. Furthermore, the decision shows that a dosage regimen can be inventive if a novel interplay between dosage regimen and mode of administration is established (see Table 4 for an overview). The Opposition Division was of the opinion that the claimed combination of trastuzumab and hyaluronidase, which have opposite charges at pH5 – pH6, would not aggregate, which alone the Opposition Division found a sufficient argument for the ackowledgement of inventive step, and hence maintained the patent. An appeal is ongoing.

Table 4.
Correlation between patent claiming trastuzumab's new dosage regimen, and approved dosage.

EP2459167B1 (Trastuzumab): Filing of a dosage patent application only when the dosage that eventually makes it into the label is known

EP2459167B1 demonstrates another important point: The clinical trials that formed the basis for the approval of the escalating dosage of rituximab in the treatment of CLL (see above) commenced on January 24, 2006. This means the patent application, claims of which were modified in an unsuccessful attempt to cover the approved regimen, was filed 7 y before that date. Quite obviously, the respective application was simply filed too early, i.e., when the applicant did not know enough about the clinically suitable dosage. In contrast thereto, the patent application that was used to protect the subcutaneous dosage for Trastuzumab, EP2459167B1, was filed one day after the respective study that formed the basis of the respective authorization began. Hence, the patent proprietor already had a clear concept of the dosage regimen for which approval was sought when filing the application. The patent application could thus be drafted accordingly to avoid any respective mismatches. An overview of this case is shown in Table 5.

Table 5.
Time lag between filing date of dosage-related patent and onset of clinical trials (when the dosage was actually established).

Conclusions

The inventive step problem

As discussed above, the development of a suitable dosage regimen of a given drug needs to carefully weigh up patient compliance, therapeutic efficacy and side effects of said drug. The difficulties and implications with finding a suitable dosages have already been pointed out by renaissance physician Paracelsus (1493 – 1541), to whom the proverb “all things are poison and nothing is without poison; only the dose makes a thing not poison” is ascribed.16 This alone suggests that a new dosage regimen can indeed rely on an inventive step.

However, it appears that patent authorities tend to oversimplify the art of developing a specific dosage regimen, probably in obedience of the postulation the EBA made in decison G2/08, according to which “the whole body of jurisprudence relating to the assessment of novelty and inventive step generally would apply” for dosage patents.17 This prejudice is reflected by the only decision of the EPO Board of Appeal 3.3.04 that is devoted to inventive step issues of antibody dosage regimen. In this case, the Board had to decide on non-obviousness of a rituximab dosage regimen in the treatment of rheumatoid arthritis (see Table 6, note that in the second decision shown in Table 6 the Board of Appeal did not opine on inventive step).

Table 6.
Decisions of the EPO Board of Appeal 3.3.04 that are devoted to antibody dosage regimen.

While the Mylotarg example shows that even slight modifications of an established dosage can make substantial differences, and thus give rise to inventive step according to the logic of the EPO, the inventive step discussion will continue to be difficult. Applicants should always provide experimental data showing that the newly claimed dosage has some kind of surprising properties, to have sufficiently convincing arguments for the inventive step discussion with the examining authorities. It should be noted that, in Europe and the US, experimental data that support an inventive step can still be provided post grant, in the prosecution phase, at least to some extent.

The timing problem

The rituximab example demonstrates problems that can arise when an application is filed too early, i.e., when the applicant does not yet know enough about the dosage that eventually is granted an approval. In such a situation, it may happen that the applicant can not adapt the claims to the actually approved dosage because this would involve the introduction of inadmissible added matter.

The problem of own prior art

A forward-looking patent lifecycle strategy should make sure that, if possible, in the first-generation patent, which protects the drug as such, no clinically meaningful dosage regimens are disclosed. This should not be a problem in most cases because, to acknowledge an inventive step and sufficient enablement of a new antibody, the Examining Divisions of the EPO usually do not demand clinical data. In-vitro data and animal data are sufficient in most cases.18 In such a strategy, a dosage regimen patent can be filed shortly before the established dosage is published, to: (1) maximize lifetime, (2) avoid prior art objections based on alleged lack of inventive step, and (3) make sure that there is an exact match between the dosage disclosed and claimed in the patent and the approved dosage.

Disclaimer

The information provided herein reflect the personal views and considerations of the author. They do not represent legal counsel and should not be attributed to Michalski · Hüttermann and Partner Patent Attorneys or to any of its clients. Patent numbers and patent lifetimes have been verified with utmost care, but no liability is taken for their correctness.

Disclosure of potential conflicts of interest

The author is involved in oppositions against some of the patent applications mentioned herein.

References

1. EPO Technical Board decision T0317/95, Board of Appeal decisions database.
2. EPO Technical Board decision T0056/97, Board of Appeal decisions database.
3. EPO Enlarged Board of Appeal decision G2/08, Board of Appeal decisions database.
4. BGH, decision of March 12, 2002 – X ZR 168/00 – Schneidmesser I; Nr 21.
5. Bryan J, Borthakur G. Role of rituximab in first-line treatment of chronic lymphocytic leukemia. Therapeutics and Clinical Risk Management 2010; 7:1-11; PMID:21339937; http://doi.org/10.2147/TCRM.S5855 [PMC free article] [PubMed] [Cross Ref]
6. Tanimoto T, Tsubokura M, Mori J, Pietrek M, Ono S, Kami M. Differences in drug approval processes of 3 regulatory agencies: a case study of gemtuzumab ozogamicin. Investigational New Drugs 2013; 31(2):473-8; PMID:22965890; http://dx.doi.org/10.1007/s10637-012-9877-8 [PubMed] [Cross Ref]
7. Castaigne S, Pautas C, Terré C, Raffoux E, Bordessoule D, Bastie J-N, Dombret H. Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): a randomised, open-label, phase 3 study. Lancet (London, England) 2012; 379(9825):1508-16; PMID:22482940; http://dx.doi.org/10.1016/S0140-6736(12)60485-1 [PubMed] [Cross Ref]
8. Chustecka Z. New lease of life for gemtuzumab, now it shows survival advantage. Medscape Medical News, December 11, 2011. (accessed April14, 2016) http://www.medscape.com/viewarticle/755219 .
9. Ravandi F, Estey EH, Appelbaum FR, Lo-Coco F, Schiffer CA, Larson RA, Kantarjian HM. Gemtuzumab ozogamicin: time to resurrect? J Clin Oncol 2012; 30(32):3921-3; PMID:22987091; http://dx.doi.org/10.1200/JCO.2012.43.0132 [PMC free article] [PubMed] [Cross Ref]
10. Chustecka Z. Gemtuzumab for leukemia: Should it be returned to market? Medscape Medical News April 5, 2012. (accessed April14, 2016); http://www.medscape.com/viewarticle/761564.
11. Castaigne S, Pautas C, Terré C, Raffoux E, Bordessoule D, Bastie J-N, Dombret H. Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): a randomised, open-label, phase 3 study. Lancet (London, England) 2012; 379(9825):1508-16; PMID:22482940; http://dx.doi.org/10.1016/S0140-6736(12)60485-1 [PubMed] [Cross Ref]
12. UK Patents Court, [2014]EWHC 1094 (Pat).
13. UK Court of Appeal, [2015]EWCA Civ 57).
14. Roche Data show Roche's new subcutaneous form of Herceptin is preferred by patients and could save resources in Europe's hospitals. Press release of 30 September 2013; http://www.roche.com/media/store/releases/med-cor-2013-09-30.htm.
15. Ratner M.. Roche plans for more convenient-to-use Herceptin and Rituxan. Nat Biotechnol 2010; 28(4):298; PMID:20379157; http://dx.doi.org/10.1038/nbt0410-298 [PubMed] [Cross Ref]
16. “Die dritte Defension wegen des Schreibens der neuen Rezepte,” Septem Defensiones 1538. Werke Bd. 2, Darmstadt 1965, p. 510.
17. EPO Enlarged Board of Appeal decision G2/08, Board of Appeal decisions database.
18. EPO Technical Board decision T 609/02, Board of Appeal decisions database.

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