PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of hviLink to Publisher's site
 
Hum Vaccin Immunother. 2016 May; 12(5): 1282–1292.
Published online 2016 April 14. doi:  10.1080/21645515.2015.1138024
PMCID: PMC4963063

Knowledge, attitudes, beliefs and behaviors of general practitioners/family physicians toward their own vaccination: A systematic review

ABSTRACT

Context: General practitioners and family physicians (GP/FPs) play a key role in the vaccination of the public in many countries and serve as role models for their patients through their own health behaviors. Objectives and Methods: a) To search for and document recommended/mandated vaccines for GP/FPs in high-income countries; b) To systematically search and review the literature on these physicians' knowledge, attitudes, beliefs, and behaviors (KABB) toward their own vaccination with the recommended/mandated vaccines and the factors determining it. Results: a) The 14 countries included recommended or mandated as many as 12 vaccines; b) The systematic review identified 11 studies published in the last 10 y. All considered seasonal influenza vaccination but differed in the variables investigated. Discussion/Conclusions: This review highlights the need for further studies on this topic, including qualitative and interventional studies (based on behavior change theories). These should cover occupational vaccines and determinants known to be associated with vaccine hesitancy.

KEYWORDS: attitude to health, general practice, immunization, primary care, vaccine, vaccine coverage, vaccine hesitancy, vaccine uptake

Introduction

General practitioners and family physicians (GP/FPs) – medical practitioners who provide personal, primary, and continuing care to individuals, families, and a practice population, irrespective of age, sex, and illness 1 – are, like other healthcare professionals, required or advised to have certain immunizations to protect themselves and their patients from some vaccine-preventable diseases.2–5 Two recent reviews showed that recommendations about occupational vaccines for health care workers (HCWs) in acute care facilities vary considerably from one country to another.2,3 Unfortunately nothing similar to the tool developed by the European Centre for Disease Prevention and Control (ECDC) to present and compare European vaccines schedule for the general populations exists for occupational vaccines for HCWs.6

In high-income countries, these physicians are usually patients' first contact in the healthcare system (either in private practices or in local primary health centers). Although their role may differ from one country to another,7 they are key actors in the implementation of vaccination policies in most of these countries.8–11 In France, for example, they administer nearly 90% of vaccines,12 and around 65% in New South Wales, Australia.13 GP/FPs not only deliver vaccines by prescribing and administering them, they also must recommend the appropriate vaccines to their patients according to national guidelines, explain vaccination and vaccines to them, and answer their questions on the subject.

Their recommendations play an influential role in their patients' vaccination behavior. Their patients perceive them as a reliable source of information about vaccines,14–16 and their consultation can also be a key factor in patients' decision to be vaccinated or not.17–21 Moreover, their recommendations to patients about vaccinations are associated with their vaccination behaviors and attitudes for themselves.22–26 Their own vaccination might be important as a proxy for their potential “vaccine hesitancy,” – a term that describes vaccination reluctance and was first studied in the general population27,28 and, more recently, also among GP/FPs.28,29 For all these reasons, identifying factors associated with their own vaccinations is important for improving vaccination coverage rates in the general population.

No review has yet been published specifically on GP/FPs' knowledge, attitudes, beliefs and behaviors (KABB) toward their own vaccination and and the factors determining it.

Our review focused on high-income countries (where the economic, organizational, and health environments of physicians are relatively comparable).30 Our objectives were: a) to search for and document recommended/mandatory vaccines for GP/FPs; and b) to search for and review articles that address GP/FPs' KABB toward their own vaccination and the factors associated with their use of these vaccines for themselves.

Review results

Recommended/mandatory vaccines for GP/FPs in 14 countries

Table 1 presents the recommended occupational vaccines for GP/FPs in 14 high-income countries, based on our consultation of national guidelines. As many as 12 vaccines were recommended in some countries, always including influenza and hepatitis B vaccines.

Table 1.
National policies for occupational vaccination of GP/FPs (not working in acute care facilities) by vaccine and by country.

Characteristics of the studies included in the systematic literature review

The systematic literature search initially identified 956 articles. A screening of titles and abstracts selected 21 studies for full text review (Fig. 1). Of these, 10 were excluded because they met at least one of our exclusion criteria. Table 2 presents the characteristics of the 11 studies finally included in the review. Screening the reference lists of these articles identified no additional study.

Figure 1.
Flow diagram of study selection procedure for the systematic literature review of knowledge, attitudes, beliefs, and behaviors of GP/FPs toward their own vaccination with recommended/mandatory vaccines.
Table 2.
Characteristics of the 11 studies included in the systematic literature review.

Seven countries were represented. Four of the 11 studies were conducted in France and 2 in non-European countries (Australia and the United States of America).

All studies identified by our literature review were cross-sectional studies that used questionnaires to assess the GP/FPs' self-reported knowledge, attitudes, beliefs and/or behaviors toward their own vaccination. All studies included seasonal influenza vaccination. Three of them also considered other vaccines.

Table 3 reports the critical appraisal of the risk of bias of these studies. Scores ranged from 2 to 7 (for a maximum score of 10, corresponding to the lowest risk of bias).

Table 3.
Results of the critical appraisal of the risk of bias of the studiesa included in this review.

Knowledge, attitudes and beliefs of GP/FPs toward their own vaccination

All the studies reported GP/FPs' vaccination behaviors, but less than half (3/11) also investigated their knowledge, attitudes, and beliefs (Table 4). Studies that provided results about knowledge showed that most of these doctors (65 to 74%) reported that they were aware of occupational recommendations.31,32 Some, however, had misconceptions about vaccines: for example, in an Australian study,32 24% incorrectly believed that the injectable seasonal influenza vaccine contains live viruses and may cause the disease. A Belgian study 33 showed a substantial fraction of GP/FPs to be unfamiliar with the duration of protection of occupational vaccines: 29% believed that the protection from the vaccine against pertussis was lifelong.

Table 4.
General practitioners' and family physicians' knowledge, attitudes, and beliefs toward their own vaccination (n = 3 studies).

Reasons for (not) being vaccinated

Figure 2 depicts the reasons GP/FPs report that they are (not) vaccinated against seasonal influenza (5 studies); 20,33–36 one study of other vaccines has also examined these reasons.33

Figure 2.
Percentages of GPs/FPs self-reported reasons for being or not being vaccinated against seasonal influenza (n = 5 studies).*One side effect was specified: influenza-like illness post-vaccination.

The two most commonly reported motives for GP/FPs' own vaccination were to protect themselves (55 to 88.5% according to the study 20,35,36) and to protect their patients (36 to 84.7% 20,34,36). The most common reasons for non-vaccination were the belief that frequent exposure already protected them (28 to 39% 33,35,36), concerns about side effects (6 to 25% 20,33,35,36), forgetfulness (9 to 28.6% 33,35,36), and doubts about the vaccine's efficacy (2.5 to 16% 20,35,36).

Factors associated with GP/FPs' own vaccination

Table 5 presents the factors found to be significantly and independently associated with GP/FPs' own vaccination in 7 studies.31,35,40 Lower self-reported rates of influenza vaccination (Fig. 3) were consistently associated with female gender and the practice of a complementary or alternative medicine (CAM), such as homeopathy or acupuncture.36–39 Conversely, increasing age (except in Paya et al.) and workload were associated with higher vaccination rates.36,38 Castilla et al. asked physicians about their concerns about acquiring influenza from patients and about transmitting it to them: both factors were associated with higher vaccination rates.38 Two French studies showed that preventive behaviors (besides vaccination) for oneself (having one's own physician rather than mainly treating oneself, testing one's own lipid profile) or being risk-averse (evaluated by 3 questions on GP/FPs' individual risks attitudes in daily life, personal finances, and their own health) were also associated with increased vaccination rates.37,39 Finally, an American study found that access to vaccine and the presence of an incentive policy in the workplace were positively associated with vaccination rates.40 For the other vaccines that were studied, increasing age was associated with decreased self-reported vaccination rates for hepatitis B and pertussis vaccines,39 as well as for DT-Polio, seasonal influenza, measles, and hepatitis B vaccines (these four vaccines were grouped as one variable in the study).31

Figure 3.
Factors significantly and independently associated with GPs' own vaccination against seasonal influenza in multivariate analyses (n=6 studies).
Table 5.
Factors independently and significantly associated with GP/FPs' own vaccination for occupational vaccines in multivariate analyses (n = 7 studies).

Discussion

This systematic review summarizes the last decade's findings on GP/FPs' own vaccinations. We identified very few studies on this topic (n = 11), which we found surprising since GP/FPs are key actors in the vaccination policies in most high-income countries. Moreover, nearly all the studies (9/11) were conducted in Europe, and very few (3/11) assessed occupational vaccines other than the seasonal influenza vaccine (which was included in all studies), even though up to 12 vaccines are recommended for these professionals (Table 1). Finally, all studies were quantitative and used questionnaires and self-reported vaccination coverage rates.

We note that we had decided from the start to exclude studies that presented data for GP/FPs combined with those of other HCWs, because findings that their own vaccination rates are usually higher than those of other HCWs 2,39,41 suggest that they may behave differently.25,42 Our literature search identified and excluded two such studies: one qualitative study (focus group) 43 and one interventional.44

The studies we included differed widely in the variables that they investigated and in the association measures they used. Therefore, their results cannot be combined and must be evaluated individually.45

This review has several strengths: 1) it documents recommended/mandatory vaccines for GP/FPs; 2) it specifically addresses their KABB toward their own vaccination and the factors determining it according to a standardized and validated process (PRISMA guidelines) and assessed the quality of selected studies; 3) it focused on high-income countries, thereby limiting heterogeneity in organizational and health contexts. Nevertheless, the results should be interpreted in the light of several limitations: 1) our inventory of recommended/mandatory vaccines for GP/FPs is not exhaustive and is limited by availability and comprehension of this type of information; 2) we cannot exclude a publication bias as we only used the Medline database for our literature search.

Assessment of the risk of bias and the quality of the studies (with the Newcastle-Ottawa scale) highlighted several methodological deficiencies. Almost all the studies used an acceptable sampling method, but most did not report a satisfactory response rate and did not test comparability between respondents and non-respondents. This may lead to potential selection bias. Most studies also failed to use a validated instrument to measure these physicians' KABB toward their own vaccination.

Previous reviews and studies of influenza vaccination among HCWs have shown that the main categories of vaccination determinants are: personal (e.g., age, gender), perceived benefits and risks of the disease/vaccination for oneself and patients/family, and factors related to convenience (e.g., sufficient free time, accessibility of vaccine); 46–48 some but not all of these variables were also studied among GP/FPs in the studies we included in our review. Increasing age and male gender were consistently associated with higher coverage rates in all reviews published in the literature,2,47,48 consistent with our findings. It is difficult to compare our results for the other factors to the published data targeting all HCWs, due to the limited number of studies included in our review. Reasons for (not) being vaccinated did not differ in any major way between the GP/FPs in our review and physician populations mixing several specialties working in primary care or even other HCWs in general.2,46,48–50 The 2 main reasons for being vaccinated were to protect oneself and to protect one's patients, with self-protection the leading factor. Feeling already protected and fear of side effects were the main reasons for not being vaccinated.

Our review identified several factors that have been associated with negative opinions toward vaccination or less inclination to be vaccinated and that could be considered to contribute to vaccine hesitancy according to the literature: practicing alternative or complementary medicine and a negative perception of the vaccine benefit-risk balance.28,51 Moreover, one of the studies showed that GP/FPs' own vaccination depended on the context,38 and such context-dependence is – according to the SAGE group 51,52 – an important aspect of vaccine hesitancy. Castilla et al. also reported that the pandemic 2009 A/H1N1 influenza outbreak might have caused GP/FPs' own vaccination rates for seasonal influenza vaccination to decline.38 However, some factors related to vaccine hesitancy in the literature, such as personal experience with illness or confidence toward health authorities, were not studied among GP/FPs.29

Improving understanding of these physicians' KABB toward their own vaccination and the factors determining it is essential because they not only act as role models for their patients, but because their behaviors for themselves can be determinant in their recommendations to their patients. This has been shown in the case of vaccination against influenza (positive association between their own and their patients' vaccination against seasonal influenza,20 personal acceptance of vaccination against pandemic influenza predictive of GP/FPs' recommendation of this vaccine to their patients22), but also, for example, for prescription of psychotherapy (GP/FPs who have undergone psychotherapy are more likely to recommend it53) or help in quitting smoking (GP/FPs who are current smokers are less likely to provide advice on quitting54).

Conclusions

Studies assessing the determinants of GP/FPs' own vaccination are urgently needed, especially to the extent that their own non-vaccination may be considered a marker of vaccine hesitancy and is associated with the vaccination recommendations they make to patients. All types of studies, including qualitative and interventional studies (based on behavior change theories), are necessary, and all occupational vaccines should be studied, since behaviors can vary substantially from one vaccine to another.39 Determinants known to be associated with vaccine hesitancy and those that may be modified by interventions should also be included,29 because dealing with GP/FPs' vaccine hesitancy is essential for improving vaccine coverage among patients.

Methods

Search for and document GP/FPs recommended/mandatory vaccines in high-income countries

The high-income countries we selected were those that posted the information on vaccines mandatory or recommended for GP/FPs not working in acute care facilities on the websites of the national health authorities.

Search for and review articles that address GP/FPs' KABB toward their own vaccination with the recommended/mandated vaccines and its determinants

Data sources

We performed a systematic review focusing on GP/FPs' knowledge, attitudes, beliefs, and behaviors toward occupational vaccines and on the determinants of these vaccines' coverage rates among them. We used the recommendations for Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA)55 as a guide to conduct the review and report the results (additional file 1). According to the PICOS approach included in PRISMA, the review objectives included:

  1. Population: GP/FPs, as defined in the introduction.
  2. Intervention/comparator: not applicable.
  3. Outcomes: KABB of GP/FPs toward their own vaccination and determinants of the coverage rates occupational vaccines.
  4. Study designs: All types of study design (including quantitative and qualitative surveys).

We searched the Medline database on April 14th, 2015, for articles published in the past 10 y, in English or in French. We used a combination of terms and synonyms referring to vaccination, coverage, and general practitioners/family physicians (the full research query is available in the additional file 2).

Study selection

We included all studies assessing any type of recommended or mandatory occupational vaccine for GP/FPs, except the vaccine against the pandemic 2009 A/H1N1 influenza, since a number of literature reviews have already studied it, among HCWs in general as well as GP/FPs in particular.23,46,56,57 We excluded studies: that covered only the pandemic 2009 A/H1N1 influenza vaccine; with data collected in a country not listed among the high-income countries (those with a gross national income per capita less than $12,736); 30 which were not original research studies or reviews; for which no abstract was available; which did not present results separately for GP/FPs (i.e. presented results mixing data for GP/FPs and other HCWs); for which no multivariate analysis was performed when studying determinants of GP/FPs' own vaccination; when vaccination coverage data were presented alone (without other data on attitudes to vaccination or determinants of vaccination); and when the sample size was too small (all exclusion criteria are listed in the additional file 3). Two authors independently screened all titles and abstracts to assess whether the studies met the inclusion criteria. Discrepancies were resolved by consensus. The reference lists of the articles selected were also screened to identify additional relevant references.

Data extraction and critical appraisal

Information on study design and population, vaccines, KABB of GP/FPs toward their own vaccination, (self-reported) vaccine coverage rates, and the results of associations tested between different factors and GP/FPs' own vaccination were extracted from all included studies. The risk of bias was evaluated independently by 2 authors using an appropriate and previously used tool – the Newcastle-Ottawa Scale adapted for cross-sectional studies (additional file 4).58 Disagreements were resolved by consensus.

Supplementary Material

KHVI_A_1138024_supp_files.zip:

Disclosure of potential conflicts of interest

No potential conflicts of interest were disclosed.

Acknowledgments

We are grateful to Jo-Ann Cahn for her help with language editing.

Authors' Contributions

FC and CP designed the review, performed the literature search, and wrote the first draft. PV and OL critically reviewed the outline of the paper and contributed significantly to the writing of the final version of the manuscript.

Funding

This research has received funding from the French National Research Agency (call for proposals issued in 2015) and joint funding from the French National Health Insurance Fund for Employees (CNAM-TS), the French Directorate General of Health (DGS), the Arc Foundation for Cancer Research, the French National Cancer Institute (INCa), the INPES, the French National Institute of Health and Medical Research (INSERM), the French Interdepartmental Agency for the Fight against Drugs and Addictive Behaviors (Mildeca) and the French Social Security Plan for the Self-Employed (RSI) as part of the “Primary Prevention” call for proposals issued by the French Institute for Public Health Research (IReSP) and the INCa in 2013. F.C. received a PhD grant from the (non-profit) Méditerranée Infection foundation (http://www.mediterranee-infection.com/).

References

[1] WONCA (The World Organization of National Colleges Academies and Academic Associations of General Practitioners/Family Physicians) International Classification Committee Wonca Int Dictionary General/Family Practice. 2003.
[2] Haviari S, Bénet T, Saadatian-Elahi M, André P, Loulergue P, Vanhems P. Vaccination of healthcare workers: A review. Hum Vaccin Immunother 2015; 11:2522-37; PMID:26291642; http://dx.doi.org/10.1080/21645515.2015.1082014 [PMC free article] [PubMed] [Cross Ref]
[3] Maltezou HC, Wicker S, Borg M, Heininger U, Puro V, Theodoridou M, Poland GA. Vaccination policies for health-care workers in acute health-care facilities in Europe. Vaccine 2011; 29:9557-62; PMID:21964058; http://dx.doi.org/10.1016/j.vaccine.2011.09.076 [PubMed] [Cross Ref]
[4] Michiels B, Philips H, Coenen S, Yane F, Steinhauser T, Stuyck S, Denekens J, Van Royen P. The effect of giving influenza vaccination to general practitioners: a controlled trial [NCT00221676]. BMC Med 2006; 4:17; PMID:16831228; http://dx.doi.org/10.1186/1741-7015-4-17 [PMC free article] [PubMed] [Cross Ref]
[5] Torner N, Solano R, Rius C, Dominguez A, Surveillance Network Of Catalonia Spain TMEP . Implication of health care personnel in measles transmission. Hum Vaccin Immunother 2015; 11:288-92; PMID:25483548; http://dx.doi.org/10.4161/hv.36166 [PMC free article] [PubMed] [Cross Ref]
[6] Vaccine Schedule [Internet]. [cited 2015. December12]; Available from: http://vaccine-schedule.ecdc.europa.eu/Pages/Scheduler.aspx
[7] Vaccine European New Integrated collaboration Effort Vaccination coverage assessment in EU / EEA , 2011. VENICE II consortium; 2012,. 73p.
[8] Leask J.. How do general practitioners persuade parents to vaccinate their children? A study using standardised scenarios. N S W Public Health Bull 2009; 20:119-24; PMID:19735623; http://dx.doi.org/10.1071/NB08064 [PubMed] [Cross Ref]
[9] Gai Y, Gu NY. Relationship between local family physician supply and influenza vaccination after controlling for individual and neighborhood effects. Am J Infect Control 2014; 42:500-5; PMID:24630702; http://dx.doi.org/10.1016/j.ajic.2013.12.006 [PubMed] [Cross Ref]
[10] Campos-Outcalt D, Jeffcott-Pera M, Carter-Smith P, Schoof BK, Young HF. Vaccines provided by family physicians. Ann Fam Med 2010; 8:507-10; PMID:21060120; http://dx.doi.org/10.1370/afm.1185 [PubMed] [Cross Ref]
[11] Loerbroks A, Stock C, Bosch JA, Litaker DG, Apfelbacher CJ. Influenza vaccination coverage among high-risk groups in 11 European countries. Eur J Public Health 2012; 22:562-8; PMID:21750011; http://dx.doi.org/10.1093/eurpub/ckr094 [PMC free article] [PubMed] [Cross Ref]
[12] Ecole des Hautes Etudes en Santé Publique Faciliter l'accès aux vaccinations en s'appuyant sur les Agences Régionales de Santé. Facilitate Access to Vaccinations with the Support of Regional Health Agencies 2013; 73 p.
[13] Departement of Health Western Australia Western Australian Immunisation Strategy. Departement of Health Western Australia 2013; 64 p.
[14] Freed GL, Clark SJ, Cowan AE, Coleman MS. Primary care physician perspectives on providing adult vaccines. Vaccine 2011; 29:1850-4; PMID:21216314; http://dx.doi.org/10.1016/j.vaccine.2010.12.097 [PubMed] [Cross Ref]
[15] Leask J, Chapman S, Hawe P, Burgess M. What maintains parental support for vaccination when challenged by anti-vaccination messages? A qualitative study. Vaccine 2006; 24:7238-45; PMID:17052810; http://dx.doi.org/10.1016/j.vaccine.2006.05.010 [PubMed] [Cross Ref]
[16] Schmitt HJ, Booy R, Aston R, Van Damme P, Schumacher RF, Campins M, Rodrigo C, Heikkinen T, Weil-Olivier C, Finn A, et al. How to optimise the coverage rate of infant and adult immunisations in Europe. BMC Med 2007; 5:11; PMID:17535430; http://dx.doi.org/10.1186/1741-7015-5-11 [PMC free article] [PubMed] [Cross Ref]
[17] Gust DA, Darling N, Kennedy A, Schwartz B. Parents with doubts about vaccines: which vaccines and reasons why. Pediatrics 2008; 122:718-25; PMID:18829793; http://dx.doi.org/10.1542/peds.2007-0538 [PubMed] [Cross Ref]
[18] Schwarzinger M, Verger P, Guerville MA, Aubry C, Rolland S, Obadia Y, Moatti JP. Positive attitudes of French general practitioners towards A/H1N1 influenza-pandemic vaccination: a missed opportunity to increase vaccination uptakes in the general public? Vaccine 2010; 28:2743-8; PMID:20117271; http://dx.doi.org/10.1016/j.vaccine.2010.01.027 [PubMed] [Cross Ref]
[19] Frank E, Dresner Y, Shani M, Vinker S The association between physicians' and patients' preventive health practices. Can Med Assoc J 2013; 185:649-53; http://dx.doi.org/10.1503/cmaj.121028 [PMC free article] [PubMed] [Cross Ref]
[20] Joseph JP, Staffolani F, Kinouani S, Broussy S, Picat MQ, Senand B, Ducos G. [Seasonal influenza vaccination coverage of general practitioners and their patients. Practice survey of French general practitioners after vaccination campaign 2011-2012.]. Rev Epidemiol Sante Publique 2014; 62:291-6; PMID:25444836; http://dx.doi.org/10.1016/j.respe.2014.07.003 [PubMed] [Cross Ref]
[21] Nessler K, Krzton-Krolewiecka A, Chmielowiec T, Jarczewska D, Windak A. Determinants of influenza vaccination coverage rates among primary care patients in Krakow, Poland and the surrounding region. Vaccine 2014; 32:7122-7; PMID:25454875; http://dx.doi.org/10.1016/j.vaccine.2014.10.026 [PubMed] [Cross Ref]
[22] Verger P, Flicoteaux R, Schwarzinger M, Sagaon-Teyssier L, Peretti-Watel P, Launay O, Sebbah R, Moatti JP. Pandemic influenza (A/H1N1) vaccine uptake among French private general practitioners: a cross sectional study in 2010. PLoS One 2012; 7:e41837; PMID:22879896; http://dx.doi.org/10.1371/journal.pone.0041837 [PMC free article] [PubMed] [Cross Ref]
[23] Poland GA.. The 2009-2010 influenza pandemic: effects on pandemic and seasonal vaccine uptake and lessons learned for seasonal vaccination campaigns. Vaccine 2010; 28Suppl 4:D3-13; PMID:20713258; http://dx.doi.org/10.1016/j.vaccine.2010.08.024 [PubMed] [Cross Ref]
[24] Abramson ZH, Levi O Is performance of influenza vaccination in the elderly related to treating physician's self Immunization and other physician characteristics? Prev Med (Baltim) 2008; 47:550-3; http://dx.doi.org/10.1016/j.ypmed.2008.08.001 [PubMed] [Cross Ref]
[25] Nichol KL, Zimmerman R. Generalist and Subspecialist Physicians' Knowledge, Attitudes, and Practices Regarding Influenza and Pneumococcal Vaccinations for Elderly and Other High-Risk Patients: A Nationwide Survey. Arch Intern Med 2001; 161:2702-8; PMID:11732935; http://dx.doi.org/10.1001/archinte.161.22.2702 [PubMed] [Cross Ref]
[26] Godoy P, Castilla J, Mayoral JM, Martín V, Astray J, Torner N, Toledo D, Soldevila N, González-Candelas F, García S, et al. Influenza vaccination of primary healthcare physicians may be associated with vaccination in their patients: a vaccination coverage study. BMC Fam Pract 2015; 16:1-7; PMID:25608667; http://dx.doi.org/10.1186/s12875-015-0259-0 [PMC free article] [PubMed] [Cross Ref]
[27] Gowda C, Dempsey AF. The rise (and fall?) of parental vaccine hesitancy. Hum Vaccin Immunother 2013; 9:1755-62; PMID:23744504; http://dx.doi.org/10.4161/hv.25085 [PMC free article] [PubMed] [Cross Ref]
[28] Dubé E, Laberge C, Guay M, Bramadat P, Roy R, Bettinger JA. Vaccine hesitancy. Hum Vaccin Immunother 2013; 9:1763-73; PMID:Can't; http://dx.doi.org/10.4161/hv.24657 [PMC free article] [PubMed] [Cross Ref]
[29] Verger P, Fressard L, Collange F, Gautier A, Jestin C, Launay O, Raude J, Pulcini C, Peretti-Watel P Vaccine Hesitancy Among General Practitioners and Its Determinants During Controversies: A National Cross-sectional Survey in France. EBioMedicine 2015; 2:891-7; http://dx.doi.org/10.1016/j.ebiom.2015.06.018 [PMC free article] [PubMed] [Cross Ref]
[30] New Country Classifications | Data [Internet] [cited 2015. December 12]; Available from: http://data.worldbank.org/news/new-country-classifications-2015
[31] Paya N, Pozzetto B, Berthelot P, Vallee J, Vallée J. [Vaccination status of family physicians in the Loire district, France]. Med Mal Infect 2013; 43:239-43; PMID:23806507; http://dx.doi.org/10.1016/j.medmal.2013.05.006 [PubMed] [Cross Ref]
[32] Ward K, Seale H, Zwar N, Leask J, MacIntyre CR. Annual influenza vaccination: Coverage and attitudes of primary care staff in Australia. Influenza Other Respi Viruses 2011; 5:135-41; PMID:21306577; http://dx.doi.org/10.1111/j.1750-2659.2010.00158.x [PMC free article] [PubMed] [Cross Ref]
[33] Semaille P, Gourbin C, Legrand D, Meyer A, Roland M, Paulus D, Bouuaert C, Trefois P, Tréfois CBP. Evaluation of the vaccine coverage of the general practitioners in the French Community. Rev Med Brux 2006; 27:S292-302; PMID:17091894 [PubMed]
[34] Socan M, Erculj V, Lajovic J. Knowledge and attitudes on pandemic and seasonal influenza vaccination among Slovenian physicians and dentists. Eur J Public Health 2013; 23:92-7; PMID:22366387; http://dx.doi.org/10.1093/eurpub/cks006 [PubMed] [Cross Ref]
[35] Opstelten W, van Essen GA, Heijnen M-L, Ballieux MJP, Goudswaard AN. High vaccination rates for seasonal and pandemic (A/H1N1) influenza among healthcare workers in Dutch general practice. Vaccine 2010; 28:6164-8; PMID:20659516; http://dx.doi.org/10.1016/j.vaccine.2010.07.031 [PubMed] [Cross Ref]
[36] Opstelten W, van Essen GA, Ballieux MJP, Goudswaard AN. Influenza immunization of Dutch general practitioners: Vaccination rate and attitudes towards vaccination. Vaccine 2008; 26:5918-21; PMID:18804133; http://dx.doi.org/10.1016/j.vaccine.2008.08.049 [PubMed] [Cross Ref]
[37] Massin S, Ventelou B, Nebout A, Verger P, Pulcini C. Cross-sectional survey: risk-averse French general practitioners are more favorable toward influenza vaccination. Vaccine 2015; 33:610-4; PMID:25545596; http://dx.doi.org/10.1016/j.vaccine.2014.12.038 [PubMed] [Cross Ref]
[38] Castilla J, Martinez-Baz I, Godoy P, Toledo D, Astray J, Garcia S, Mayoral JMJM, Martin V, Gonzalez-Candelas F, Guevara M, et al. Trends in influenza vaccine coverage among primary healthcare workers in Spain, 2008-2011. Prev Med (Baltim) 2013; 57:206-11; http://dx.doi.org/10.1016/j.ypmed.2013.05.021 [PubMed] [Cross Ref]
[39] Pulcini C, Massin S, Launay O, Verger P. Factors associated with vaccination for hepatitis B, pertussis, seasonal and pandemic influenza among French general practitioners: a 2010 survey. Vaccine 2013; 31:3943-9; PMID:23806242; http://dx.doi.org/10.1016/j.vaccine.2013.06.039 [PubMed] [Cross Ref]
[40] Cowan AE, Winston CA, Davis MM, Wortley PM, Clark SJ. Influenza vaccination status and influenza-related perspectives and practices among US physicians. Am J Infect Control 2006; 34:164-9; PMID:16679171; http://dx.doi.org/10.1016/j.ajic.2005.09.007 [PubMed] [Cross Ref]
[41] Guthmann JP, Fonteneau L, Ciotti C, Bouvet E, Pellissier G, Lévy-Bruhl D, Abiteboul D. Vaccination coverage of health care personnel working in health care facilities in France: results of a national survey, 2009. Vaccine 2012; 30:4648-54; PMID:22579863; http://dx.doi.org/10.1016/j.vaccine.2012.04.098 [PubMed] [Cross Ref]
[42] Ridda I, Lindley R, MacIntyre RC. Differences in the attitude and knowledge of hospital health care workers regarding older patient vaccinations. Hum Vaccin 2009; 5:761-4; PMID:19901541; http://dx.doi.org/10.4161/hv.5.11.9869 [PubMed] [Cross Ref]
[43] Yassi A, Lockhart K, Buxton JA, McDonald I. Vaccination of Health Care Workers for Influenza: Promote Safety Culture, Not Coercion. Can J public Health 2010; 101:S41-5; PMID:20629446 [PubMed]
[44] Abramson ZH, Avni O, Levi O, Miskin IN. Randomized trial of a program to increase staff influenza vaccination in primary care clinics. Ann Fam Med 2010; 8:293-8; PMID:20644183; http://dx.doi.org/10.1370/afm.1132 [PubMed] [Cross Ref]
[45] The Cochrane Collaboration 9.1.4 When not to use meta-analysis in a review [Internet]. In: Higgins JPT GS, editor. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. 2011. [cited 2015 Dec 12]. Available from: http://handbook.cochrane.org/chapter_9/9_1_4_when_not_to_use_meta_analysis_in_a_review.htm
[46] Bellia C, Setbon M, Zylberman P, Flahault A Healthcare worker compliance with seasonal and pandemic influenza vaccination. Influenza Other Respi Viruses 2013; 7:97-104; http://dx.doi.org/10.1111/irv.12088 [PubMed] [Cross Ref]
[47] Vasilevska M, Ku J, Fisman DN. Factors Associated with Healthcare Worker Acceptance of Vaccination: A Systematic Review and Meta-analysis. Infect Control Hosp Epidemiol 2014; 35:699-708; PMID:24799647; http://dx.doi.org/10.1086/676427 [PubMed] [Cross Ref]
[48] Hollmeyer HG, Hayden F, Poland G, Buchholz U. Influenza vaccination of health care workers in hospitals-A review of studies on attitudes and predictors. Vaccine 2009; 27:3935-44; PMID:19467744; http://dx.doi.org/10.1016/j.vaccine.2009.03.056 [PubMed] [Cross Ref]
[49] Yaqub O, Castle-Clarke S, Sevdalis N, Chataway J. Attitudes to vaccination: a critical review. Soc Sci Med 2014; 112:1-11; PMID:24788111; http://dx.doi.org/10.1016/j.socscimed.2014.04.018 [PubMed] [Cross Ref]
[50] Hofmann F, Ferracin C, Marsh G, Dumas R. Influenza vaccination of healthcare workers: a literature review of attitudes and beliefs. Infection 2006; 34:142-7; PMID:16804657; http://dx.doi.org/10.1007/s15010-006-5109-5 [PubMed] [Cross Ref]
[51] Larson HJ, Jarrett C, Eckersberger E, Smith DMD, Paterson P. Understanding vaccine hesitancy around vaccines and vaccination from a global perspective: A systematic review of published literature, 2007–2012. Vaccine 2014; 32:2150-9; PMID:24598724; http://dx.doi.org/10.1016/j.vaccine.2014.01.081 [PubMed] [Cross Ref]
[52] WHO SAGE working group dealing with vaccine hesitancy (March 2012 to November 2014) [Internet]. 2012. [cited 2015 Dec 12]; Available from: http://www.who.int/immunization/sage/sage_wg_vaccine_hesitancy_apr12/en/
[53] Dumesnil H, Cortaredona S, Verdoux H, Sebbah R, Paraponaris A, Verger P. General practitioners' choices and their determinants when starting treatment for major depression: a cross sectional, randomized case-vignette survey. PLoS One 2012; 7:e52429; PMID:23272243; http://dx.doi.org/10.1371/journal.pone.0052429 [PMC free article] [PubMed] [Cross Ref]
[54] Meshefedjian GA, Gervais A, Tremblay M, Villeneuve D, O'Loughlin J. Physician smoking status may influence cessation counseling practices. Can J Public Health 2010; 101:290-3; PMID:21033533 [PubMed]
[55] Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA, Group P-P Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015. Syst Rev 2015; 349:g7647 [PubMed]
[56] Prematunge C, Corace K, McCarthy A, Nair RC, Pugsley R, Garber G. Factors influencing pandemic influenza vaccination of healthcare workers-A systematic review. Vaccine 2012; 30:4733-43; PMID:22643216; http://dx.doi.org/10.1016/j.vaccine.2012.05.018 [PubMed] [Cross Ref]
[57] Brien S, Kwong JC, Buckeridge DL. The determinants of 2009 pandemic A/H1N1 influenza vaccination: a systematic review. Vaccine 2012; 30:1255-64; PMID:22214889; http://dx.doi.org/10.1016/j.vaccine.2011.12.089 [PubMed] [Cross Ref]
[58] Herzog R, Álvarez-Pasquin MJ, Díaz C, Del Barrio JL, Estrada JM, Gil Á. Are healthcare workers' intentions to vaccinate related to their knowledge, beliefs and attitudes? A systematic review. BMC Public Health 2013; 13:154; PMID:23421987; http://dx.doi.org/10.1186/1471-2458-13-154 [PMC free article] [PubMed] [Cross Ref]
[59] Impfempfehlungen für das Gesundheitspersonal in Österreich - [Vaccination recommendations for health professionals in Austria] [Internet]. [cited 2015 Dec 12]; Available from: http://bmg.gv.at/home/Schwerpunkte/Gesundheitsfoerderung_Praevention/Impfen/Impfempfehlungen_fuer_das_Gesundheitspersonal_in_Oesterreich
[60] Vaccination fact sheets published by the SHC [Internet]. 2015. [cited 2015 Dec 12]; Available from: http://www.health.belgium.be/eportal/Aboutus/relatedinstitutions/SuperiorHealthCouncil/publications/factsheetsvaccination/index.htm?fodnlang=en#.VhdvkytV3RI
[61] Arrêté royal du 4 août 1996 concernant la protection des travailleurs contre les risques liés à l'exposition à des agents cancérigènes au travail - [Royal Decree of 4 August 1996 on the protection of workers against the risks related to exposure to biolog [Internet]. 1999; Available from: www.emploi.belgique.be/WorkArea/DownloadAsset.aspx?id=2132
[62] Ministere des Affaires sociales et de la Sante Calendrier des vaccinations et recommandations vaccinales 2015 - [Schedule of vaccinations and vaccine recommendations in 2015]. [Internet]. Ministère des Affaires sociales, de la Santé et des Droits des femmes; 2015. Available from: http://www.sante.gouv.fr/IMG/pdf/Calendrier_vaccinal_2015.pdf
[63] RKI Epidemiologisches Bulletin - Epidemiological Bulletin of the Robert Koch Institute. [Internet]. Robert Koch Institute; [cited 2015. December12]. Available from: http://www.rki.de/DE/Content/Infekt/EpidBull/Archiv/2015/Ausgaben/34_15.pdf?__blob=publicationFile
[64] Ministero della Salute Piano Nazionale Prevenzione Vaccinale - National Plan Vaccine Prevention. [Internet]. Ministero della Salute; 2012. [cited 2015 Dec 12]. Available from: http://www.salute.gov.it/imgs/C_17_pubblicazioni_1721_allegato.pdf
[65] Health Service Executive Immunisation Guidelines [Internet]. 2013. [cited 2015 Dec 12]; Available from: http://www.hse.ie/eng/health/immunisation/hcpinfo/guidelines/immunisationguidelines.html
[66] Kennissyteem infectieziekten en arbeid (KIZA) Vaccinaties en beroepen - [Vaccinations and professions]. [Internet]. [cited 2015. December12]; Available from: http://www.kiza.nl/content/vaccinaties-en-beroepen-z
[67] Ministerio de Sanidad , Servicios Sociales e Igualdad - Profesionales - SALUD PUBLICA - PREVEN CION DE LA SALUD - VACUNACIONES - PROGRAMA VACUNACION [Internet]. [cited 2015. November12]; Available from: http://www.msssi.gob.es/profesionales/saludPublica/prevPromocion/vacunaciones/home.htm
[68] Socialstyrelsen - [The National Board of Health and Welfare ]. [Internet]. [cited 2015. December12]; Available from: http://www.socialstyrelsen.se/
[69] Federal Office of Public Health Schweizerischer Impfplan - [Swiss vaccination plan]. [cited 2015. December12]; Available from: http://www.bag.admin.ch/ekif/04423/04428/
[70] Public Health England Immunisation against infectious disease. [Internet]. [cited 2015. December12]; Available from: https://www.gov.uk/government/collections/immunisation-against-infectious-disease-the-green-book
[71] Australian Government Department of Health Immunisation Handbook 10th Edition (updated June 2015) [Internet]. [cited 2015. December12]; Available from: http://www.immunise.health.gov.au/internet/immunise/publishing.nsf/Content/Handbook10-home
[72] Government of Canada Public Health Agency of Canada Immunization of Workers - Part 3 - Vaccination of Specific Populations - Canadian Immunization Guide - Public Health Agency of Canada. 2013. [cited 2015 Dec 12]; Available from: http://www.phac-aspc.gc.ca/publicat/cig-gci/p03-work-travail-eng.php
[73] CDC Vaccines - Adult Immunization Schedules and Tools for Providers [Internet]. [cited 2015. December12]; Available from: http://www.cdc.gov/vaccines/schedules/hcp/adult.html

Articles from Human Vaccines & Immunotherapeutics are provided here courtesy of Taylor & Francis