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Logo of jbcThe Journal of Biological Chemistry
 
J Biol Chem. 2016 July 15; 291(29): 14914.
PMCID: PMC4946910

A unique microRNA profile in end-stage heart failure indicates alterations in specific cardiovascular signaling networks.

VOLUME 284 (2009) PAGES 27487–27499

This article has been withdrawn by the authors. Evaluation by the journal with image analysis software determined that in Fig. 5A, lanes 1–3 of the RB1 immunoblot were duplicated in lanes 4–6, lane 4 of the ERBB2 immunoblot was duplicated in lane 6, lane 5 of the STAT3 immunoblot was duplicated in lane 8, and lanes 1–3 of the actin immunoblot were flipped horizontally and reused in lanes 6–8. The authors state that RB1, ERRB2, STAT3, and actin in Fig. 5A were created from phosphor-chemiluminescent digital imaging. The authors also state that they have replicate data supporting the conclusions of Fig. 5, A and B. In Fig. 6B, evaluation by the journal of the original data determined that single cell background fluorescence was duplicated. The authors maintain that the concern is about a single background cell not a positive cell to show transfection efficiency and is inconsequential to proving transfection.


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