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J Neurol Neurosurg Psychiatry. 1977 October; 40(10): 1018–1020.
PMCID: PMC492887

Mood disorder as a specific complication of stroke.

Abstract

In an effort to discern whether cerebral vascular injuries provoke specific emotional disturbances, 20 consecutively admitted stroke patients were compared with 10 orthopaedic patients. Both groups were examined for functional disabilities (Activities of Daily Living) and for psychiatric symptoms. Reliable and valid instruments, the Hamilton Rating Scale, the Visual Analogue Mood Scale, the Present State Exam, and the Mini-Mental State Exam were employed to display the psychopathology. More of stroke patients than orthopaedic patients were depressed (45% versus 10%) even though the level of functional disability in both groups were the same. Patients with right hemisphere stroke seemed particularly vulnerable and and displayed a syndrome of irritability, loss of interest, and difficulty in concentration, in addition to depression of mood (70% of right hemisphere stroke patients versus 0% left hemisphere stroke patients and 0% orthopaedic patients). We conclude that mood disorder is a more specific complication of stroke than simply a response to the motor disability. We suggest that a controlled trial of antidepressant medication is indicated for patients with this complication.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • ADAMS GF, HURWITZ LJ. MENTAL BARRIERS TO RECOVERY FROM STROKES. Lancet. 1963 Sep 14;2(7307):533–537. [PubMed]
  • Bell DS. Psychiatric aspects of cerebral vascular disease. Med J Aust. 1966 Oct 29;2(18):829–833. [PubMed]
  • Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975 Nov;12(3):189–198. [PubMed]
  • Folstein MF, Luria R. Reliability, validity, and clinical application of the Visual Analogue Mood Scale. Psychol Med. 1973 Nov;3(4):479–486. [PubMed]
  • Luria RE, McHugh PR. Reliability and clinical utility of the "Wing" Present State examination. Arch Gen Psychiatry. 1974 Jun;30(6):866–871. [PubMed]
  • Robinson RG, Shoemaker WJ, Schlumpf M, Valk T, Bloom FE. Effect of experimental cerebral infarction in rat brain on catecholamines and behaviour. Nature. 1975 May 22;255(5506):332–334. [PubMed]

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