Search tips
Search criteria 


Logo of mjafiGuide for AuthorsAbout this journalExplore this journalMedical Journal, Armed Forces India
Med J Armed Forces India. 2011 April; 67(2): 194–195.
Published online 2011 July 21. doi:  10.1016/S0377-1237(11)60037-3
PMCID: PMC4920756

Supplemental oxygen therapy in bleomycin-induced pulmonary toxicity: REPLY

At the outset, on behalf of all the authors, I thank the reader for having shown keen interest in the article entitled “Reversible Bleomycin Toxicity” published in the July issue of MJAFI.1 The reader has brought out clinically relevant and important issues pertaining to exacerbation/precipitation of bleomycin-induced pulmonary toxicity caused by supplemental oxygen administration particularly in the context of general anaesthesia. As mentioned in our article, exposure to high-dose oxygen is one of the several important risk factors known for development of bleomycin pulmonary toxicity. We did not go into the details of the risk factors of bleomycin toxicity as our article focused mainly on the unusual HRCT features of bleomycin toxicity and imaging (HRCT) demonstration of reversibility of the lesions. I agree with the comments of the reader concerned with regard to the potentially serious synergistic effects of supplemental oxygen therapy in a patient with prior exposure to bleomycin. Exposure to bleomycin appears to sensitise the lungs and potentially fatal acute lung damage can occur at an inspired oxygen concentration which is otherwise considered normal for a healthy individual. However, this issue is debatable.2, 3 Nevertheless, it may be clinically relevant as many of the patients who receive bleomycin therapy for a variety of disorders are relatively young and may subsequently undergo surgery where general anaesthesia would be considered. Awareness and knowledge of these risk factors would certainly prove invaluable in preventing/avoiding perioperative complications in a patient with prior exposure to bleomycin. At this point, I would like to mention that the issue of perioperative reduction of oxygen in patients with prior exposure to bleomycin is also debatable.4, 5

There are conflicting reports regarding the role of pulmonary function tests and carbon monoxide diffusing capacity (DLco) as an indicator of bleomycin-induced pulmonary toxicity.6, 7 However, the general consensus is that DLco has an important role in this regard. As enquired by the reader, I would like to inform here that our patient did not receive any supplemental oxygen therapy after the administration of bleomycin. At the last review, which was approximately six months after stoppage of bleomycin, the individual was asymptomatic, a repeat pulmonary function test was normal. Repeat DLco test was done and was normal. After going through the existing literature and the pertinent comments of the reader, I think, it may be worthwhile to document in the medical records as well as personal health card and also brief the patient/care taker concerned on the recent exposure to bleomycin and possible potential complications if need arises for supplemental oxygen therapy or general anaesthesia for any reason in future. This may be particularly relevant for the Armed Forces population who move from place to place.


1. Debnath J, Singh HP, George RA. Reversible bleomycintoxicity. MJAFI. 2010;66:290–291.
2. LaMantia KR, Glick J, II, Marshall BE. Supplemental oxygen does not cause respiratory failure in bleomycin treated surgical patients. Anaesthesiology. 1984;60:65–67. [PubMed]
3. Ingrassia TS, 3rd, Ryu JH, Trastck VF, Rosenow EC., 3rd Oxygen exacerbated bleomycin pulmonary toxicity. Mayo Clan Proc. 1991;66:173–178. [PubMed]
4. Waid-Jones MI, Coursin DB. Perioperative considerations for patients treated with bleomycin. Chest. 1991;99:993–999. [PubMed]
5. Donat SM, Levy DA. Bleomycin associated pulmonary toxicity: is perioperative oxygen restriction necessary? J Urol. 1998;160:1347–1352. [PubMed]
6. Serensen PG, Rossing N, Rorth M. Carbon monoxide diffusing capacity: a reliable indicator of bleomycin induced pulmonary toxicity. Eur J Respir Dis. 1985;66:33–40. [PubMed]
7. McKeage MJ, Evans BD, Atkinson C, Perez D, Forgeson GV, Dady PJ. Carbon monoxide diffusing capacity is a poor predictor of clinically significant bleomycin lung. New Zealand Clinical Oncology Group. J Clin Oncol. 1990;8:779–783. [PubMed]

Articles from Medical Journal, Armed Forces India are provided here courtesy of Elsevier