Search tips
Search criteria 


Logo of jnnpsycJournal of Neurology, Neurosurgery and PsychiatryVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
J Neurol Neurosurg Psychiatry. 1981 May; 44(5): 426–429.
PMCID: PMC490987

Bromocriptine in Parkinson's disease: a study of cardiovascular effects.


Blood pressure and pulse rate were studied in 20 Parkinsonian patients on no treatment, and during treatment with bromocriptine (mean dosage 148 mg/day) as the sole anti-Parkinsonian therapy. The drug was shown to reduce erect systolic and diastolic and supine systolic blood pressure and to increase erect pulse rate, in a predictable dose-dependent manner. The occurrence of episodes of significant postural hypotension was less predictable and was a transitory phenomenon in all patients. Peripheral dopamine receptor blockade with domperidone did not alter the findings, suggesting that the principal mechanism for these cardiovascular effects is a central dopaminergic one.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (471K), or click on a page image below to browse page by page.

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Group