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Ophthalmol Ther. 2016 June; 5(1): 81–94.
Published online 2016 May 19. doi:  10.1007/s40123-016-0053-7
PMCID: PMC4909680

Electronic Patient Records to Identify Patients in the United Kingdom with Diabetic Macular Oedema Suitable for ILUVIEN® (Fluocinolone Acetonide)



We describe a proactive method using electronic patient records (EPR) to identify pseudophakic patients with diabetic macular oedema (DMO) that might benefit from treatment with 0.2 µg/day fluocinolone acetonide (FAc; ILUVIEN®) implant.


Our EPR audit tool (Medisoft®) identified diabetic patients (May 2011–December 2014) with National Screening Committee-confirmed grade M1 maculopathy. Searches segmented this DMO patient population into patient groups who: (1) had received ranibizumab therapy, (2) had received ≥2 macular laser treatments, or (3) were unsuitable for macular laser or ranibizumab therapy. Pre-specified criteria identified patients insufficiently responsive to treatment, and their electronic case notes were flagged for clinicians to consider FAc, based on National Institute for Health and Care Excellence (NICE) TA301.


Using this methodology, 138 patients with DMO were identified, of whom 87 were assigned to group 1, 32 to group 2, and 29 to group 3 (10 patients were included in both groups 2 and 3). From these, 28 different pseudophakic eyes were identified as suitable for treatment with FAc, based on insufficient response to prior treatment.


EPR audit offers a real-world methodology to efficiently identify patients that might benefit from treatment with FAc. Limitations apply, and thorough documentation of lens status and ocular comorbidities is vital; however, this approach was more rapid than prospective recruitment through the clinic. Flagging patient records using EPR audit offers a practical process for application to clinical practice, thereby optimizing patient care in line with NICE TA301 guidelines.


Alimera Sciences Ltd.

Electronic supplementary material

The online version of this article (doi:10.1007/s40123-016-0053-7) contains supplementary material, which is available to authorized users.

Keywords: Diabetic macular oedema, Fluocinolone acetonide, ILUVIEN, NICE, Patient records


Diabetic retinopathy (DR) is a common, vision-limiting vascular complication of diabetes with a prevalence of approximately 35% [1, 2]. A visual complication manifesting in 6.8% of patients with DR is diabetic macular oedema (DMO), a chronic condition and the most common cause of DR-related vision-loss, particularly in patients with type 2 diabetes [2, 3]. 14–25% of patients diagnosed with diabetes appear to develop DMO within 10 years of the initial diagnosis [4].

Given the association between DMO and vision loss, its early and effective management is critical. However, as a chronic and persistent visual complication that does not follow the natural disease course of DR, it is difficult to manage [3]. Historically, the standard of care was laser therapy, and this approach is still widely used. More recently, the preferred standard of care in patients with DMO has become anti-VEGF therapy [5]. This approach is supported by the outcomes from several large, prospective, randomized clinical trials demonstrating improvements in DMO and associated visual function [68]. However, a notable proportion of patients remain insufficiently responsive to anti-VEGF treatment in clinical practice, as shown by a cohort of patients (n = 190) in the RIDE and RISE trials ( identifiers: NCT00473382 and NCT00473330, respectively), who crossed over from sham to ranibizumab treatment after two years. In this patient group, the improvement in VA after 1 year of therapy was notably less when compared with 1-year gain in VA in patients who initiated ranibizumab at the start of the study [mean 2.8 vs. 11.1 Early Treatment Diabetic Retinopathy (ETDRS) letter gain, respectively] [7, 8] suggesting that patients with a longer duration of DMO (chronic DMO) were less likely to achieve a response with ranibizumab.

Diabetic macular oedema is a multifactorial disease, involving the up-regulation of multiple inflammatory cytokines in addition to VEGF [9]. Consequently, corticosteroids, which have a broader-spectrum of activity, may represent an alternative therapeutic option for patients with chronic DMO. Data from the Fluocinolone Acetonide in Diabetic Macular Edema [FAME ( identifier. NCT00344968)] trials indicate efficacy of 0.2 µg/day FAc implant in DMO [17]. In Europe, 0.2 μg/day FAc implant is approved for the treatment of vision impairment associated with chronic DMO considered insufficiently responsive to available therapies [10]. In the UK, the National Institute for Health and Care Excellence (NICE; TA301) recommends 0.2 μg/day FAc implant as an option for treating chronic DMO that is insufficiently responsive to available therapies in eyes that are pseudophakic [11].

The timely implementation of NICE technology appraisals (TAs) is an ethical responsibility and an opportunity to enhance patient care. National Health Service (NHS) trusts have 3 months to implement guidance and a proactive, methodical approach is needed to optimise TA implementation. Medisoft® (Medisoft Ltd., Leeds, UK) is an electronic patient records (EPR) database, which in our practice contains the details for a large diabetic patient population. Here, we report a methodology that utilizes this EPR audit tool to identify patients who may have sub-optimal responses to current first-line treatment options (anti-VEGF or laser) and consequently, who might benefit from 0.2 μg/day FAc implant. This methodology can be approached from different angles to optimally identify patient groups that meet pre-specified criteria for insufficient response or treatment failure. The data presented within this manuscript are based on searches using EPR records for patients within the Calderdale and Huddersfield NHS Foundation Trust, which serves a population of approximately 22,500 patients with type 1 and type 2 diabetes in Calderdale and South Kirklees, UK. To our knowledge, no prior studies have reported the use of EPR audit to identify patients with DMO suitable for subsequent therapy.


Using the Medisoft EPR tool, searches spanning May 2011–May 2014 were conducted using pre-determined search terms (see the Appendix in the supplementary material), tailored to identify all patients referred to the Calderdale and Huddersfield NHS Foundation Trust with National Screening Committee (NSC)-confirmed grade M1 maculopathy [i.e., exudate within 1 disc diameter (DD) of the centre of the fovea, circinate or group of exudates within the macula, retinal thickening within 1DD of the centre of the fovea (if stereo available) or any microaneurysm or haemorrhage within 1DD of the centre of the fovea only if associated with a best visual acuity (VA) of ≤6/12 (if no stereo)]. Identified patients were further divided into 3 pre-specified patient groups that might include patients who could benefit from 0.2 μg/day FAc implant (Fig. 1). For each of these patient groups, information on patient demographics and disease history were gathered, as was information relating to therapeutic interventions, VA (ETDRS letter score) and anatomical measures of DMO [e.g., central retinal thickness (CRT) according to optical coherence tomography (OCT) map, µm]. Patients who might benefit from 0.2 μg/day FAc were identified in each of the 3 patient groups (Fig. 1), based on the demographic and disease characteristics, and the corresponding electronic case notes were flagged as potentially suitable for therapy with a note for the clinician to consider 0.2 μg/day FAc implant based on TA301. The selection process and methodology for identifying patients is outlined for each group below. This article does not contain any new studies with human or animal subjects performed by any of the authors.

Fig. 1
Schematic illustrating the three different patient groups identified using the Medisoft® EPR tool. EPR electronic patient records

Group 1: Patients Insufficiently Responsive to Ranibizumab

The EPR audit tool was used to identify patients among those patients with NSC-confirmed grade M1 maculopathy who had received ranibizumab treatment (Fig. 1). Patient records were exported for identified patients, excluding any with non-DMO indications. For this analysis, treatment success was evaluated in eyes that had received ≥3 consecutive ranibizumab injections. The selection of this time point for the assessment of response is supported by the results of the Early Anti-VEGF Response and Long-term Efficacy (EARLY) study, which showed that long-term response to anti-VEGF therapy in patients with DMO could be predicted after three injections ( identifier. NCT00445003) [12]. Patients with a baseline VA of >68 letters were considered unresponsive to ranibizumab if they achieved less than a 20% reduction in CRT or a loss in VA of >5 letters. In patients who had a baseline VA of <68 letters, non-response to ranibizumab treatment was defined as less than 20% reduction in CRT or a gain in VA of <5 letters. The exported patient records were reviewed to determine which pseudophakic patients (to comply with NICE TA301) [11] with DMO were insufficiently responsive to ranibizumab based on these response criteria, and their patient records flagged accordingly.

Group 2: Patients Unresponsive to Macular Laser Therapy

The EPR audit tool was used to identify which patients with NSC-confirmed grade M1 maculopathy had received more than one macular laser treatment (Fig. 1, group 2). In addition, those patients assigned to group 1 during the EPR search, having received ranibizumab, were cross-checked and any duplicate patient entries deleted; therefore, all patients included in group 2 were ranibizumab naïve. Records for patients with non-DMO indications were excluded.

The selected patient records were exported and reviewed to identify pseudophakic patients with DMO unresponsive to macular laser therapy. Patients who had received more than one laser treatment with persistent DMO (based on clinical judgement of OCT maps and CRT values >250 µm) were deemed to have failed laser therapy.

Group 3: Patients Unsuitable for Ranibizumab or Macular Laser Treatment

Those patients with NSC-confirmed grade M1 maculopathy who were originally identified and who did not conform to the criteria specified for inclusion in group 1 or 2 were included in group 3 (excluding all patients with non-DMO indications; Fig. 1). These patients had CRT greater than 250 µm but less than 400 µm and so were considered unsuitable for ranibizumab treatment in the UK, based on NICE TA274 guidance (recommends ranibizumab only in patients with CRT >400 µm) [13]. Consequently, patient records were screened to identify those patients where macular laser therapy might not be optimal and anti-VEGF therapy is not recommended, but who might benefit from early intervention with 0.2 μg/day FAc implant to reduce CRT and manage DMO progression effectively. Of note, this patient group included some patients who were unsuitable for laser or ranibizumab therapy but who had received prior laser therapy. Consequently, such patients who had received two or more laser treatments were ‘counted twice’ as they were also included in group 2.


Overall, the EPR search identified 138 patients with DMO, whose demographic characteristics were broadly as anticipated (Table S1 in the supplementary material). The average patient age was 64 years [range 27–86 years; standard deviation (SD) ±13.1 years], and most patients were male (n = 85). The majority of patients had type 2 diabetes (n = 112). Of the 138 patients (264 eyes), 67 eyes were pseudophakic, 123 were phakic, and in the remaining 74 eyes the lens status was not documented (Fig. 1).

Group 1: Patients Insufficiently Responsive to Ranibizumab

Overall, 87 patients had received treatment with ranibizumab and were allocated to group 1 (Table S1). Of the 87 patients, 26 eyes from 26 patients were pseudophakic and had received ≥3 consecutive ranibizumab injections.

At baseline, 16/26 patients had a best-corrected (BC) VA of <68 letters, and 10 patients had a BCVA of >68 letters; mean BCVA was 57.5 letters (range 24–75 years; SD ±14.2 years). Baseline CRT ranged from 320 to 880 µm, with a mean CRT of 473.8 µm (SD ±111.8 µm). Three eyes were excluded from further analysis; 1 patient was awaiting follow-up at the time of analysis and 1 had concomitant wet age-related macular degeneration (wAMD). The third patient was not insufficiently responsive to ranibizumab based on the defined study criteria; however, they received 0.2 µg/day FAc implant based on physician assessment.

Based on the pre-specified parameters for insufficient response following ranibizumab therapy, 13 eyes were determined to have failed ranibizumab therapy and consequently were considered suitable for 0.2 μg/day FAc implant; in these eyes there was a mean reduction in CRT of −110.3 µm (SD ±142.8 µm) and a change in BCVA of −5.7 letters (SD ±12.1 letters) from pre-ranibizumab baseline was reported. In the remaining 10/26 eyes, which were responding to ranibizumab, a mean reduction in CRT of −203.7 microns (SD ±99.2) and mean increase in BCVA of 9.4 letters (SD ±10.6 letters) was reported. Table 1 presents the data on prior interventions as well as CRT and BCVA at baseline and following ranibizumab therapy for each eye.

Table 1
Prior therapeutic interventions and CRT and BCVA at baseline and post-ranibizumab (≥3 consecutive injections) in pseudophakic patients with diabetic macular oedema

Group 2: Patients Unresponsive to Macular Laser Therapy

Overall, 50 eyes from 32 patients were ranibizumab naïve and had received more than 1 macular laser treatment, of which 13 were pseudophakic and a further 15 had unknown lens status. The majority of patients received more than 2 laser treatments and 5 eyes reported co-pathologies (Table 2). At the time of analysis, the most recent CRT ranged from 219 to 368 µm (mean 286.9 µm; SD ±53.3 µm) and the most recent BCVA from 42 to 82 letters. The majority of patients (n = 16) had a BCVA in line with driving vision (70 letters) or better. Table 2 presents the data on functional and anatomical visual measurements for each eye.

Table 2
Prior laser therapy, co-pathologies, and CRT and BCVA at referral (baseline) and most recent measure (post-laser) in pseudophakic patients and patients with unknown lens status (e.g., may be pseudophakic) with diabetic macular oedema who had received ...

Based on the pre-specified criteria, 10/13 pseudophakic eyes were deemed to have failed macular laser therapy and thus were considered potential candidates for 0.2 μg/day FAc implant. In these patients, the mean change in CRT and BCVA from baseline (referral) were +8.2 µm (SD ±54.7 µm) and −13.1 letters (SD ±11.1 letters), respectively. Patients with unknown lens status were considered unsuitable for 0.2 μg/day FAc implant at this time, as their lens status was assumed to be phakic.

Group 3: Patients with Centre-Involving DMO Unsuitable for Ranibizumab or Macular Laser Treatment

Overall, 40 eyes from 29 patients were allocated to group 3 (Table S1). In those patients (n = 23) who were pseudophakic or with unknown lens status, 11 eyes had previously received 1–3 laser treatments and 3 eyes reported co-pathologies (Table 3). BCVA at referral ranged from 50 to 90 letters (mean 78.4 letters; SD ±12.0 letters), and appeared relatively stable with a mean recent BCVA at the time of analysis of 74.3 letters (range 54–90 letters; SD ±8.1 letters). CRT was <400 µm in all patients and ranged from 228 to 345 µm (mean 297.2 µm; SD ±31.1 µm). Of the 23 eyes, 5 pseudophakic eyes were selected as suitable candidates for 0.2 μg/day FAc implant [eye 4 was also counted in group 2 (eye 1)]. All 5 patients had good VA (mean 72.0 letters; SD ±12.7 letters) and CRT >250 µm (mean 303.0 µm; SD ±28.5 letters). Patients with unknown lens status were considered unsuitable for 0.2 μg/day FAc implant at this time, as their lens status was assumed to be phakic.

Table 3
Prior therapeutic interventions, CRT, and BCVA in patients with centre-involving diabetic macular oedema who were pseudophakic or who had unknown lens status (e.g., may be pseudophakic)


In this study, we used a simple, EPR-based methodology to identify patients insufficiently responsive to their current treatments and consequently potential candidates for 0.2 μg/day FAc implant. Using the defined search criteria, 13 pseudophakic eyes from 87 patients were identified as unresponsive to ranibizumab and potentially suitable for 0.2 μg/day FAc implant (and have subsequently been treated). Similarly, of the pseudophakic eyes identified in groups 2 and 3, 10 and 5 eyes, respectively, were considered potential candidates for 0.2 μg/day FAc implant. Of these, 7 and 2 patients, respectively, have received a 0.2 μg/day FAc implant.

NICE TA301 criteria state that pseudophakic patients with DMO can be treated with 0.2 μg/day FAc implant where other standard therapies have shown an insufficient response [11]. To identify appropriate patients who are insufficiently responsive and who might benefit from this treatment, a practical approach with broad applicability is required. This study demonstrates the utility of an EPR audit tool to identify appropriate patients, based on pre-defined search criteria. Different search criteria were applied, allowing the identification of patients who were either insufficiently responsive, or unsuitable for conventional treatments. The time required to identify patients with this approach was in the order of a few days, compared with the long process (months) of prospective identification through the clinic.

The anti-VEGF injection, ranibizumab, reaches therapeutic stability following treatment initiation with 3 consecutive monthly injections; after this time, the majority of potential visual gain has been achieved [14, 15]. Consequently, for patients treated with ranibizumab in this study, success was evaluated in patients who had received ≥3 consecutive ranibizumab injections. The criteria for treatment success were defined as a function of baseline VA. In patients with good baseline vision (≥68 letters), but anatomical evidence for vision-threatening DMO (e.g., CRT ≥400 µm), the aim of treatment was to improve DMO (≥20% reduction in CRT) or a gain of vision (>5 letters). However, in patients with worse vision (<68 letters), the aim of treatment was considered to be an improvement in DMO or maintenance of visual function (<5 letter gain). It is arguably of particular importance to identify treatment failure early in this latter group, as a retrospective analysis of the FAME studies demonstrated that visual outcomes were better in patients with chronic DMO with less deterioration in baseline BCVA whether they were treated with intermittent therapies or 0.2 μg/day FAc implant; however, patients in the latter group achieved notably better outcomes [16].

A potentially overlooked cohort is those patients with DMO who have a CRT <400 µm. It is assumed that, as they cannot access ranibizumab therapy in the UK due to a lack of evidence for cost-effectiveness in this patient group [13], they will be treated with macular laser therapy. However, a proportion of patients exist for whom laser therapy would be potentially damaging, for example if the laser needs to be applied close to the centre of the retina. In addition, patients may have CRT <400 µm, but have received prior laser therapy that had been unsuccessful. This group of patients has a need for effective intervention to optimise outcomes and limit the damaging effects of progressive DMO, and thus represent a subgroup that may benefit from 0.2 μg/day FAc implant. Here, patients with CRT <400 µm but >250 µm who were not suitable for laser or ranibizumab therapy were reviewed to consider their suitability for 0.2 μg/day FAc implant, identifying a further 5 pseudophakic eyes whose records were flagged accordingly.

In this study, we have shown the potential to use the EPR audit tool effectively, proactively, and rapidly to identify patients who are insufficiently responsive or failing to respond to current standard-of-care treatments. In addition, we propose a practical mechanism for the clinical application of this methodology through the flagging of individual patient records. This approach allows the efficient and timely identification of patients who might benefit from 0.2 μg/day FAc implant, which has both ethical and socioeconomic implications. Earlier, effective treatment has the potential for improved visual outcomes and subsequent quality of life, which in turn affects the patients’ ability to work and the frequency of treatment visits required. While the current study has illustrated that there may be a therapeutic solution for pseudophakic patients with insufficient response to their current therapy, there remains a significant gap in care options for phakic patients that is not currently addressed. Additionally, this retrospective approach could highlight a number of other patient groups that are not being effectively treated, and for whom there is a question of optimal management.


There are several important considerations and potential limitations to consider. Complete documentation of current lens status and the presence of ocular comorbidities is necessary for the effective identification of suitable patients, and whilst paper and EPR systems are in concurrent use, it is likely that neither record will be complete. However, in the UK there is a paperless initiative in place, which mandates that all patient records should be fully digital by April 2018, with a clear move towards a paper-light system by 2015 [17]. This will require complete digital documentation, both facilitating and enhancing the value of an EPR audit system such as that described here. However, more extensive digital patient records will not obviate the need for appropriate consideration of optimal search terms. Additionally, this study was performed within the context of the UK healthcare system using a specific EPR tool. However, the objectives of the study are relevant to other healthcare systems and the methodology is likely to be transferable to other technology platforms; the flexibility of EPR tools allows the use of locally derived criteria for the selection of specific patient populations.


To conclude, EPR audit offers a real-world and readily applicable methodology for optimizing treatment options in patients with DMO.

Electronic supplementary material

Below is the link to the electronic supplementary material.


Medical writing support was provided by QXV Comms (an Ashfield business, part of UDG Healthcare plc), Macclesfield, UK, and was fully funded by Alimera Sciences Ltd. The research and publication of this article was supported by Alimera Sciences Ltd. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this manuscript, take responsibility for the integrity of the work as a whole, and have given final approval for the version to be published.


Farhat Butt has received travel grants to attend ophthalmology conferences, and has received part of a medical education grant to fund the time spent collecting data for this work from Alimera Sciences. Rehna Khan has received travel grants to attend ophthalmology conferences, and has received part of the above medical education grant to support eye clinic nurse training and purchase of equipment for the eye department. There are no other financial declarations relevant to this work. Saadia Chaudhry and Kamron Khan declare no potential conflict of interest.

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This article does not contain any new studies with human or animal subjects performed by any of the authors.

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