Biological peptide sequences collected in PhosphoAtlas provide a new depth and unique dimension into kinase–substrate catalytic interactions
a. Individual kinases (red discs) are plotted based on the number of unique connecting substrates (x-axis) and related HPS target per substrate ratio (y-axis). Some kinases are annotated by name along with number of unique HPS per number of unique substrates in parenthesis.
b. Circos plots visualize the number of kinase-substrate (left) and kinase-HPS-substrate (right) connections for selected kinases.
c. Protein substrates (blue discs) are plotted based on the number of unique connecting kinases and peptide per kinase ratio. Annotated substrates are identified by name followed by the number of known HPS targets within it per number of kinases it is phosphorylated by.
d. Circos plots visualize the number of kinase–substrate (left) and kinase–peptide–substrate (left) connections for selected examples of substrates.
e. HPS’s (green discs) are plotted based on the number of unique interacting kinases (x-axis) and substrate per kinase ratio (y-axis). Every peptide in the plot is an N-term to C-term amino acid sequence annotated in parenthesis with the number of substrates it is found within per number of kinases that it is targeted by.
f. Circos plots visualize the number of kinase–substrate and kinase–peptide–substrate connections for different entries.