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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
 
Org Lett. Author manuscript; available in PMC 2017 April 1.
Published in final edited form as:
PMCID: PMC4887141
NIHMSID: NIHMS787856

Palladium-Catalyzed Benzylic Arylation of Pyridylmethyl Silyl Ethers: One-Pot Synthesis of Aryl(pyridyl)methanols

Abstract

An efficient palladium-catalyzed direct arylation of pyridylmethyl silyl ethers with aryl bromides is described. A Pd(OAc)2/NIXANTPHOS-based catalyst provides aryl(pyridyl)-methyl alcohol derivatives in good to excellent yields (33 examples, 57–100% yield). This protocol is compatible with different silyl ether protecting groups, affording either the protected or the free alcohols in an effective one-pot process. The scalability of the reaction is demonstrated.

Graphical Abstract

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Nitrogen heterocycles are among the most widespread structural components of pharmaceuticals.1 Among these, pyridines are frequent subunits of medicinally relevant molecules and materials.1g–n Specifically, the aryl(pyridyl)-methanol core is commonly found in drug candidates, either as the free alcohol or ether (Figure 1).2

Figure 1
Biologically active compounds containing aryl(pyridyl)-methanol subunits.

Palladium-catalyzed benzylic arylation of picolinyl derivatives has been employed to access heterocyclic building blocks.3 Traditionally, such reactions require the presence of directing groups, such as 2-(2-pyridyl)ethanols,3b pyridine N-oxides,3d,4 N-iminopyridines,3e or 2-(2-pyridyl)acetic acids.3h Other methods for the benzylic functionalization of substituted pyridines rely on the addition of activating agents. For instance, a Lewis acid can be added to the reaction mixture to bind the pyridyl nitrogen, preventing its coordination while also increasing the acidity of the benzylic hydrogens and facilitating the catalytic process.3j,5 Although effective, these methods have limited substrate scope and reduced synthetic efficiency. The coordination of the pyridyl group to palladium and inhibition or deactivation of the catalyst is also problematic.6

Given the success of deprotonative cross-coupling processes (DCCP) in the functionalization of a variety of weakly acidic sp3 C–H bonds,7 we envisioned application of this approach to the functionalization of substituted pyridines.7q,u We recently reported the Pd(OAc)2/NIXANTPHOS-catalyzed DCCP of pyridylmethyl ethers to generate either arylated secondary ethers (Scheme 1A) or tertiary alcohols via tandem arylation/ [1,2]-Wittig rearrangement (Scheme 1B).7u Secondary aryl-(pyridyl)methanols (Figure 1) are also highly desirable but not accessible via the chemistry in Scheme 1A or B.

Scheme 1
Pd-Catalyzed Benzylic C–H Arylation of Pyridylmethyl Ethers

We hypothesized that pyridylmethyl silyl ethers might undergo reversible deprotonation in the presence of a palladium catalyst and aryl bromides to generate arylated silyl ethers or the corresponding free alcohols (Scheme 1C). Herein, we report the catalytic arylation of pyridylmethyl silyl ethers to afford either the silyl protected or free alcohols, using a Pd(NIXANTPHOS)-based catalyst.

Based on the general utility of the Pd(OAc)2/NIXANT-PHOS-based catalyst in a range of reactions,7j–u we began by investigating the benzylic C–H arylation of 2-pyridylmethyl silyl ether 1a with bromobenzene 2a using Pd(OAc)2 (1 mol %) and NIXANTPHOS (1.5 mol %, see Table 1 for structure). Several combinations of silyl amide bases MN(SiMe3)2 (M = Li, Na, K) and solvents [toluene, 1,4-dioxane, THF, 2-methyltetrahydrofuran (2-MeTHF), cyclopentyl methyl ether (CPME), and 1,2-dimethoxyethane (DME)] were evaluated to identify suitable reaction conditions (Table 1, entries 1–10).

Table 1
Optimization of Benzylic C–H Arylation of 2-Pyridylmethyl Silyl Ether 1aa

It was found that LiN(SiMe3)2 in DME provided a quantitative yield of the desired coupling (Table 1, entry 6). Unfortunately, attempts to decrease the amount of LiN-(SiMe3)2 from 3 equiv to 1.5 equiv resulted in incomplete reaction after 18 h at 45 °C (entries 6 and 11). Increasing the temperature from 45 to 85 °C and using 1.5 equiv of LiN(SiMe3)2 led to 98% yield after 3 h (entry 12). We were surprised to find that reducing the amount of bromobenzene (2a) to 1.0 equiv still gave 98% yield (entry 13). Furthermore, only a small drop in the reaction yield (from 98% to 89%) was found when the NIXANTPHOS loading was dropped from 1.5 to 1.0 mol % (entries 13 and 14).

With the optimized reaction conditions in hand [pyridyl-methyl silyl ether (1, 1 equiv), aryl bromide (2, 1 equiv), LiN(SiMe3)2 (1.5 equiv), Pd(OAc)2/NIXANTPHOS (1 mol % each), DME (0.2 M) at 85 °C], we explored the scope of aryl bromides in the DCCP (Scheme 2). In general, a variety of aryl bromides (2ag) led to the formation of aryl(2-pyridyl)methyl silyl ethers 3 with good to high yields (69–88%). The arylation was compatible with aryl bromides bearing electron-donating substituents 4-t-Bu, 4-OMe, 4-NMe2 (3acae, 84–88% yield) or electron-withdrawing 4-F and 4-Cl (3af and 3ag in 85% and 70% yield, respectively).

Scheme 2
Scope of Aryl Bromides 2 in Benzylic C–H Arylation of 2-Pyridylmethyl Silyl Ether 1aa

The presence of the 2-pyridyl groups in Scheme 2 might lead to the conclusion that chelation is a prerequisite for arylation. Thus, we examined the 4-pyridyl analogues to probe this question and expand the method (Scheme 3). The arylation of 4-pyridylmethyl silyl ether 1b took place at room temperature, suggesting these substrates are more reactive than the 2-pyridyl derivatives. This result is consistent with the greater acidity of 4-methylpyridine over 2-methylpyridine.8 The reactions of 4-pyridylmethyl silyl ethers provided the desired products with a broad range of aryl bromides. These include electronically neutral (Ph, 2-naphthyl, 4-t-Bu,) and electron-rich (4-OMe, 4-NMe2) aryl bromides, which provided products 3babe in 83–97% yield. Aryl bromides with electron-withdrawing groups, such as 4-F and 4-Cl, 3-CF3, formed products 3bfbh in 74–95% yield. In addition, more challenging substrates, such as sterically hindered 2-bromotoluene and heterocycles (3-bromopyridine, 6-bromoquinoline, 5-bromobenzofuran, and N-methyl-5-bromoindole) successfully underwent DCCP at room temperature (3bibm, 57–85%), albeit at 5 mol % catalyst loading (Scheme 3). Moreover, the scalability of the method was evaluated by performing the arylation of 4-pyridylmethyl silyl ether 1b with bromobenzene (2a) on a 4 mmol scale. The desired product (3ba) was obtained in 91% yield (1.09 g, Scheme 3).

Scheme 3
Scope of Aryl Bromides 2 in Benzylic C–H Arylation of 4-Pyridylmethyl Silyl Ether 1ba

Next, we assessed different silyl groups. In order to evaluate the impact of silyl group size on the arylation reaction outcome, triisopropylsilyl (TIPS) ether and trimethylsilyl (TMS) ether protecting groups were examined.

Both 2- and 4-pyridine derivatives with TIPS and TMS groups coupled with aryl bromides to provide the desired products in good to excellent yields (57–100%, Scheme 4). 2-Pyridyl-containing substrates with bulky TIPS groups required 3 equiv of base and 2 mol % catalyst loading for complete conversion.

Scheme 4
Scope of Arylation of Pyridylmethyl Silyl Ethersa

Finally, we explored the feasibility of a one-pot arylation/ desilylation sequence to generate free secondary alcohols. Substrates with different silyl groups were arylated under the standard reaction conditions and then directly treated with 1.5 equiv of TBAF. As shown in Scheme 5, 4-pyridylmethyl silyl ether 1b and 2-pyridylmethyl silyl ether 1e provided the corresponding alcohols 4ba and 4ea respectively, with high yields (94% and 84%). The 3-pyridylmethyl silyl ether 1g is more challenging because of the higher pKa of the benzylic C–H’s.8 After some optimization, we found that 3 equiv of LiN(SiMe3)2, 2 equiv of 4-tert-butylbromobenzene (2c), and 5 mol % catalyst loading in DME at 85 °C generated arylation product. Workup with 1.5 equiv of TBAF provided the free alcohol 4gc in 66% yield.

Scheme 5
One-Pot Arylation/Deprotection of Pyridylmethyl Silyl Ethersa

In summary, a deprotonative cross-coupling process for the direct arylation of pyridylmethyl silyl ethers has been developed. In most cases, this method requires 1 equiv of aryl bromide, 1.5 equiv of base, and many substrates react well at 1 mol % catalyst loading. Electron-donating and electron-withdrawing aryl bromides as well as heteroaryl bromides undergo the coupling in good to excellent yields. In addition, the reaction is compatible with different sized silyl-protecting groups. A convenient one-pot cross-coupling/desilylation sequence was demonstrated to directly obtain arylated secondary alcohols. Our method has advantages over the addition of organometallic reagents, such as organolithiums and Grignard reagents, to aldehydes. Many more aryl bromides are commercially available than aryl Grignard reagents. Furthermore, our method circumvents the use of aldehydes, which are often contaminated with oxidation products. We anticipate that this method will be useful in the synthesis of aryl pyridylmethyl alcohols for exploration of their structure–activity relationship.

Supplementary Material

SI

Acknowledgments

Financial support for this work was provided by NIH/NIGMS (GM 104349) and the National Science Foundation (CHE-1464744). A.R.R. acknowledges the Spanish MEC for an FPU grant and a Visiting Scientist Fellowship to University of Pennsylvania.

Footnotes

Notes

The authors declare no competing financial interest.

*Supporting Information

The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.or-glett.6b00450.

Experimental details and characterization data for all new compounds (PDF)

References

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