PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of heartHeartVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
 
Heart. 1996 December; 76(6): 467–470.
PMCID: PMC484595

Spin-echo nuclear magnetic resonance for tissue characterisation in arrhythmogenic right ventricular cardiomyopathy.

Abstract

OBJECTIVE: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a myocardial disorder characterised clinically by ventricular arrhythmias that can cause cardiac arrest and morphologically by fatty or fibro-fatty myocardial atrophy of the right ventricle. In vivo tissue characterisation without endomyocardial biopsy would be useful. The aim of this study was to investigate the diagnostic accuracy of spin-echo nuclear magnetic resonance (NMR) for tissue characterisation in ARVC. PATIENTS AND METHODS: Twenty three subjects (15 men and eight women, aged 18-49, mean 34) were studied with spin-echo T1-weighted NMR and multislice scan. Fifteen had a clinical diagnosis of ARVC and eight were controls (age and sex matched subjects). Data were independently evaluated by two expert observers. RESULTS: In the control group NMR was always negative (100% specificity). Ten of the 15 patients with ARVC had an abnormal NMR result (67% sensitivity), with areas that had a signal intensity close to that of pericardial or subcutaneous fat. In the remaining five cases the NMR signal was inadequate. Nine patients underwent both NMR and endomyocardial biopsy; biopsy was positive in eight (89%) and NMR was positive in five (56%). CONCLUSIONS: NMR is a useful non-invasive diagnostic tool in the evaluation of fatty replacement in ARVC. The technique can be used with other procedures in the initial diagnostic evaluation and is a useful alternative tool in the long term follow up of patients with ARVC.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.2M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Click on the image to see a larger version.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Marcus FI, Fontaine GH, Guiraudon G, Frank R, Laurenceau JL, Malergue C, Grosgogeat Y. Right ventricular dysplasia: a report of 24 adult cases. Circulation. 1982 Feb;65(2):384–398. [PubMed]
  • Fontaine G, Guiraudon G, Frank R, Tereau Y, Fillette F, Marcus FI, Chomette G, Grosgogeat Y. Dysplasie ventriculaire droite arythmogène et maladie de Uhl. Arch Mal Coeur Vaiss. 1982 Apr;75(4):361–371. [PubMed]
  • Thiene G, Nava A, Corrado D, Rossi L, Pennelli N. Right ventricular cardiomyopathy and sudden death in young people. N Engl J Med. 1988 Jan 21;318(3):129–133. [PubMed]
  • Corrado D, Thiene G, Nava A, Rossi L, Pennelli N. Sudden death in young competitive athletes: clinicopathologic correlations in 22 cases. Am J Med. 1990 Nov;89(5):588–596. [PubMed]
  • Basso C, Thiene G, Corrado D, Angelini A, Nava A, Valente M. Arrhythmogenic right ventricular cardiomyopathy. Dysplasia, dystrophy, or myocarditis? Circulation. 1996 Sep 1;94(5):983–991. [PubMed]
  • Laurent M, Descaves C, Biron Y, Deplace C, Almange C, Daubert JC. Familial form of arrhythmogenic right ventricular dysplasia. Am Heart J. 1987 Mar;113(3):827–829. [PubMed]
  • Nava A, Thiene G, Canciani B, Scognamiglio R, Daliento L, Buja G, Martini B, Stritoni P, Fasoli G. Familial occurrence of right ventricular dysplasia: a study involving nine families. J Am Coll Cardiol. 1988 Nov;12(5):1222–1228. [PubMed]
  • Rampazzo A, Nava A, Danieli GA, Buja G, Daliento L, Fasoli G, Scognamiglio R, Corrado D, Thiene G. The gene for arrhythmogenic right ventricular cardiomyopathy maps to chromosome 14q23-q24. Hum Mol Genet. 1994 Jun;3(6):959–962. [PubMed]
  • Rampazzo A, Nava A, Erne P, Eberhard M, Vian E, Slomp P, Tiso N, Thiene G, Danieli GA. A new locus for arrhythmogenic right ventricular cardiomyopathy (ARVD2) maps to chromosome 1q42-q43. Hum Mol Genet. 1995 Nov;4(11):2151–2154. [PubMed]
  • McKenna WJ, Thiene G, Nava A, Fontaliran F, Blomstrom-Lundqvist C, Fontaine G, Camerini F. Diagnosis of arrhythmogenic right ventricular dysplasia/cardiomyopathy. Task Force of the Working Group Myocardial and Pericardial Disease of the European Society of Cardiology and of the Scientific Council on Cardiomyopathies of the International Society and Federation of Cardiology. Br Heart J. 1994 Mar;71(3):215–218. [PMC free article] [PubMed]
  • Ehman RL, Julsrud PR. Magnetic resonance imaging of the heart: current status. Mayo Clin Proc. 1989 Sep;64(9):1134–1146. [PubMed]
  • Angelini A, Thiene G, Boffa GM, Calliari I, Daliento L, Valente M, Chioin R, Nava A, Volta SD, Calliaris I [corrected to Calliari I] Endomyocardial biopsy in right ventricular cardiomyopathy. Int J Cardiol. 1993 Jul 15;40(3):273–282. [PubMed]
  • Hamada S, Takamiya M, Ohe T, Ueda H. Arrhythmogenic right ventricular dysplasia: evaluation with electron-beam CT. Radiology. 1993 Jun;187(3):723–727. [PubMed]
  • Klersy C, Raisaro A, Salerno JA, Montemartini C, Campani R. Arrhythmogenic right and left ventricular disease: evaluation by computed tomography and nuclear magnetic resonance imaging. Eur Heart J. 1989 Sep;10 (Suppl 500):33–36. [PubMed]
  • Wolf JE, Rose-Pittet L, Page E, Borrel E, Bertrand B, Lebas JF, Machecourt J, Coulomb M, Denis B. Mise en évidence par l'IRM des lésions pariétales au cours de dysplasies arythmogènes du ventricule droit. Arch Mal Coeur Vaiss. 1989 Oct;82(10):1711–1717. [PubMed]
  • Blake LM, Scheinman MM, Higgins CB. MR features of arrhythmogenic right ventricular dysplasia. AJR Am J Roentgenol. 1994 Apr;162(4):809–812. [PubMed]
  • Auffermann W, Wichter T, Breithardt G, Joachimsen K, Peters PE. Arrhythmogenic right ventricular disease: MR imaging vs angiography. AJR Am J Roentgenol. 1993 Sep;161(3):549–555. [PubMed]
  • Molinari G, Sardanelli F, Gaita F, Ottonello C, Richiardi E, Parodi RC, Masperone MA, Caponnetto S. Right ventricular dysplasia as a generalized cardiomyopathy? findings on magnetic resonance imaging. Eur Heart J. 1995 Nov;16(11):1619–1624. [PubMed]
  • Daubert C, Descaves C, Foulgoc JL, Bourdonnec C, Laurent M, Gouffault J. Critical analysis of cineangiographic criteria for diagnosis of arrhythmogenic right ventricular dysplasia. Am Heart J. 1988 Feb;115(2):448–459. [PubMed]
  • Daliento L, Rizzoli G, Thiene G, Nava A, Rinuncini M, Chioin R, Dalla Volta S. Diagnostic accuracy of right ventriculography in arrhythmogenic right ventricular cardiomyopathy. Am J Cardiol. 1990 Sep 15;66(7):741–745. [PubMed]
  • Blomström-Lundqvist C, Beckman-Suurküla M, Wallentin I, Jonsson R, Olsson SB. Ventricular dimensions and wall motion assessed by echocardiography in patients with arrhythmogenic right ventricular dysplasia. Eur Heart J. 1988 Dec;9(12):1291–1302. [PubMed]
  • Scognamiglio R, Fasoli G, Nava A, Miraglia G, Thiene G, Dalla-Volta S. Contribution of cross-sectional echocardiography to the diagnosis of right ventricular dysplasia at the asymptomatic stage. Eur Heart J. 1989 Jun;10(6):538–542. [PubMed]
  • Robertson JH, Bardy GH, German LD, Gallagher JJ, Kisslo J. Comparison of two-dimensional echocardiographic and angiographic findings in arrhythmogenic right ventricular dysplasia. Am J Cardiol. 1985 Jun 1;55(13 Pt 1):1506–1508. [PubMed]

Articles from Heart are provided here courtesy of BMJ Group