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Immunol Allergy Clin North Am. Author manuscript; available in PMC 2017 May 1.
Published in final edited form as:
PMCID: PMC4834138

Rhinitis in the elderly


By the year 2050, the US aging population will nearly double. As the US aging population grows, it will be increasingly important for healthcare providers to effectively diagnose and manage rhinitis. The nasal symptoms of rhinorrhea, congestion, sneezing, nasal/ocular pruritus, and postnasal drainage affect up to 32% of older adults, and can significantly impact the quality of life. Several underlying factors associated with aging (such as structural changes and immunosenescence) may contribute to the pathogenesis of rhinitis in older adults. Although treatment options for rhinitis exist, special considerations need to be made as comorbidities, limited income, memory loss, and side effects of medications frequently occur in older adults and may impact outcomes.

Keywords: Rhinitis, allergic rhinitis, nonallergic rhinitis, atrophic rhinitis, elderly, older adults

Epidemiology of rhinitis in the elderly

Unfortunately, older adults are routinely excluded from large epidemiological studies on rhinitis. For example, both NHANES III and the European SAPALDIA study (which each had over 8000 participants) excluded anyone over the age of 60 when analyzing rhinitis outcomes and prevalence.[1] Allergic rhinitis appears to decrease with age, and older literature has suggested a prevalence of approximately 12%.[2] However, more recent literature suggests that this figure may significantly underestimate the current rhinitis prevalence rate.[3] Results from the NHANES 2005 – 2006 study found that the self-reported prevalence of rhinitis was approximately 32% among those between the age of 54-89, which was no different than younger adult populations (Figure 1).[4] However, in that study adults aged 54 – 89 had significantly lower rates of allergic sensitization compared to younger age groups (though approximately 33% of older adults were positive for inhalant allergen sensitivity on skin testing). Overall, it appears that nonallergic rhinitis increases with age, and the highest prevalence is seen in the elderly.[5]

Figure 1
Self-reported rhinitis and allergic sensitization among participants in the NHANES 2005-2006 study.

Types of rhinitis in the elderly

Allergic Rhinitis

Allergic rhinitis (AR) is characterized by intermittent or persistent symptoms of nasal congestion, rhinorrhea, nasal/ocular pruritus, sneezing, and postnasal drainage. These symptoms are a result of IgE mediated allergic inflammation in the nasal mucosa triggered by various allergens. Triggering allergens may be seasonal or perennial. The seasonal allergens include pollen and mold while perennial allergens include dust mites, pet dander and pests (cockroach, mice). A key component to diagnosing AR is objective evidence of allergen sensitivity. Allergy skin testing (prick and intracutaneous) or serum testing for specific IgE is used to assess allergen sensitization to environmental allergens. Allergen sensitization as well as total IgE, has been shown to diminish with age [6-8].

Recent reports have revealed a subset of rhinitis patients with a positive nasal provocation to allergens despite negative skin prick tests [9, 10]. It has been hypothesized that these patients have localized AR. Further studies are needed to gain a better understanding of the immunopathology, prevalence, practical diagnostic tests, and management of localized AR especially in older adults.

Non-allergic Rhinitis

Non-allergic rhinitis (NAR) is characterized by symptoms of nasal congestion, rhinorrhea, and postnasal drainage in the absence of specific IgE-dependent events [11]. The diagnosis of NAR is based on clinical history and exclusion of other causes of rhinitis. The symptoms of NAR may be persistent, intermittent, seasonal (climatic) and/or elicited by recognized triggers. These triggers include cold air, changes in climate, strong odors, pollutants, chemicals and exercise to name a few. Gustatory rhinitis is a form of NAR triggered by eating which can be a frequent complaint of older rhinitis patients [12].

Mixed Rhinitis

Non-allergic rhinitis frequently co-occurs in 44% to 87%of patients with allergic rhinitis. This condition (NAR and AR) is called mixed rhinitis and has multiple triggers (e.g. pollens, change in weather, strong odors)[13]. The clinical presentation of mixed rhinitis can be variable and is characterized by intermittent or persistent rhinitis symptoms that are not fully explained by specific IgE sensitization (Figure 2). Despite the often-similar clinical presentation, it is important to assess for the presence of both by identifying symptom triggers. Recognition of co-occurrence of these two common conditions, will help clinicians provide the most effective and appropriate treatment and help reduce significant morbidity associated with both diseases.

Figure 2
Type of rhinitis seen in the elderly

Atrophic Rhinitis

Atrophic rhinitis is a type of rhinitis which is more prevalent in older adult populations [14]. This type of rhinitis is manifested by symptoms of congestion, nasal crusting and fetor. Decreased blood flow to the nasal mucosa contributes to the local atrophy and leads to the enlargement of nasal space with paradoxical nasal congestion[14]. Atrophic rhinitis can overlap with both allergic and nonallergic rhinitis (Figure 1).

Differential Diagnosis of Rhinitis

It is important, especially in the older adult, to examine for comorbidities that may cause or contribute to rhinitis. The differential is varied from granulomatous diseases such as Wegner’s granulomatosis and sarcoidosis to nasal polyposis, hypothyroidism, cerebrospinal fluid leak and malignancy (Box 1). Many medications that are widely used in older adults such as anti-hypertensives, psychotropics, alpha-adrenergic antagonists and phosphodiesterase-5 inhibitors can cause a drug-induced rhinitis (Box 2).

Box 1

Differential Diagnosis for Rhinitis in Older Adults

  • Allergic rhinitis
    • ○ Intermittent
    • ○ Persistent
  • Nonallergic rhinitis
    • ○ Vasomotor rhinitis
    • ○ Gustatory rhinitis
    • ○ Infectious
    • ○ NARES
  • Occupational rhinitis
    • ○ Caused by protein and chemical allergens, immunoglobulin E (IgE)–mediated
    • ○ Caused by chemical respiratory sensitizers, immune mechanism uncertain
    • ○ Work-aggravated rhinitis
  • Other rhinitis syndromes
    • ○ Hormonally induced
    • ○ Drug induced
    • ○ Atrophic rhinitis
  • Rhinitis associated with inflammatory-immunologic disorders
    • ○ Granulomatous infections
    • ○ Wegener granulomatosis
    • ○ Sarcoidosis
    • ○ Midline granuloma
    • ○ Churg-Strauss
    • ○ Relapsing polychondritis
    • ○ Amyloidosis
  • Cerebrospinal fluid leak
  • Nasopharyngeal Malignancy

Adapted from Wallace DV, Dykewicz MS, Bernstein DI, et al. The diagnosis and management of rhinitis, an updated practice parameter. J Allergy Clin Immunol 2008;122(Suppl):S1–84; with permission.

Box 2

Medications that can cause or contribute to rhinitis

  • Alpha blockers (doxazosin, terazosin)
  • ACE inhibitors
  • Beta-blockers (carvedilol, labetalol, nadolol)
  • Calcium channel blockers
  • Diuretics
  • Oxymetolazone
  • Oral contraceptives
  • Phosphodiesterase 5 inhibitors (sildenafil, tadalafil, vardanafil)
  • Psychotropics (risperidone, chlorpromazine, amitriptyline)
  • Phentolamine

Special Considerations in Older Adults

Age-related Nasal Changes

With normal aging, there are several changes that occur in the nasal anatomy and physiology that may impact the presence and severity of rhinitis symptoms. Structural changes including loss of nasal tip support due to weakening of fibrous connective tissue at the upper and lower lateral cartilages and collagen fiber atrophy that leads to a dropped nasal tip[15, 16]. Furthermore, fragmentation and weakening of septal cartilage and nasal columella retraction causes changes in the nasal cavity[16]. The changes associated with the natural aging process may decrease nasal airflow and the symptoms of nasal congestion often found in older adults.

In addition to structural changes in the nose, mucosal changes are found with normal aging. The mucosal epithelium becomes atrophic and dry. A decrease in mucosal blood flow has been found with increasing age[17]. The decreased blood flow can contributes to decreased humidification of the nasal passages as the submucosal vessels are not able to warm and moisten the inspired air sufficiently[17]. The decreased humidification of the nose leads to dryness, crusting and irritation.

There are also change in the visco-elastic properties of nasal mucus which account for the excessively thick mucus in older adults[18]. Thick mucus mixed with impaired mucociliary function leads to the rhinitis symptoms of chronic postnasal drainage, nasal drainage and cough[18]. Additionally, there is an increase in cholinergic activity in the nose with age that causes an increase in post-nasal drainage[19].

Aging is also associated with decreases in olfaction, with the greatest decline occurring usually after the seventh decade. Seiberling demonstrated that both the sense of smell and ability to distinguish two smells diminishes with age[20]. Diminished olfaction is also commonly found in rhinitis patients. One study found that 71% of patients with dysosmia had evidence of allergic sensitization[21]. The dysosmia that occurs in allergic rhinitis is attributed to obstruction of the nasal passages, though Pinto demonstrated inflammation of the olfactory cleft might be the cause[22]. Older adults with rhinitis thus have two contributing factors to olfactory dysfunction.

Immunosenescence and rhinitis

There is a growing body of evidence describing changes in the function of immune cells with aging, a phenomenon referred to as “immunosenescence”. As rhinitis is a disease of inflammation, alterations in immune cell function with age may impact rhinitis in older adults. With normal aging, the thymus rapidly involutes, resulting in a decline in total T cells (CD3+) involving both CD4+ and CD8+ subsets. In addition, a decrease in naïve T cells and an increase in the production of memory T cells. Despite the increase in memory T cells, their responses and T cell proliferative responses to antigens and mitogens are diminished[23-25]. Finally, with aging, an increase in FOXP3+ CD4+ regulatory T cells exerting suppressive effects on T-cell function along with a shift in cytokine pattern from T-helper type 1 (Th1) to Th2 also have been described[26, 27]. These changes in cytokine patterns may explain late onset rhinitis and the decreases in T cell response may be associated with the increase in infections found in older adults.

B cell function also changes with aging. The peripheral B cell population remains constant though there is less IgG isotype class switching and then total number of antigen-specific antibodies decreases [28, 29]. This may be one explanation for why older adults are more prone to infection and have decreased immune response to vaccines. These aberrations in B cells may contribute to the symptoms of rhinitis, including infectious rhinitis.

Impact of comorbidities

As people age, it is not surprising that the number of medical conditions and medications to manage these conditions increases. In the United States, 40% of those above the age of 65 use 5 or more prescription medications on a daily basis.[30] Patients with multiple chronic medical problems have several challenges to ensure optimal management of each of their conditions. There can be interactions between conditions, difficulties in determining which medical problem is primarily active when the symptoms are similar, decreased compliance with multiple medications, and conflicting recommendations in selfcare management.[31]

Medication and self-management costs can increase exponentially in elderly patients with multiple comorbidities, and therefore certain conditions may receive suboptimal care due to a lower prioritization by the individual.[32] Previous research has demonstrated that physicians often ignore and underdiagnose rhinitis.[33] This may due to competing medical conditions and limited time spent during an examination – especially relevant among older adults with multiple comorbidities. While rhinitis is typically not a life-threatening condition, it can significantly affect quality of life,[34] and is deserving of care among older adults.

A few specific comorbidities deserve special mention when considering rhinitis in the elderly. Depression has been associated with anosmia, rhinitis, and chronic sinonasal disease in a number of studies.[35-38] While the exact cause is unknown, theories for the association include sleep disturbance, inflammatory cytokine upregulation, and common etiologic pathogenic factors. Depression and depressive syndromes have an extremely high prevalence among the elderly population, with rates ranging from 15 to 35%.[39, 40] One study found that compared to placebo, treatment of depression and/or anxiety with escitalopram improved nasal symptoms, though participants in this study were under the age of 50 years.[41] It is also important to note that multiple psychiatric medications can cause nasal drying or rhinitis, and therefore knowledge of the side effects of drugs that each patient is taking (even when prescribed by another physician) is critically important.

A second common comorbidity among the elderly is gastroesophageal reflux disease (GERD). The prevalence of this condition is thought to increase with age,[42] and among the elderly up to 22% of individuals have GERD.[43] A recent 10 year prospective cohort study found that those with nocturnal GERD were 60% more likely to develop rhinitis symptoms, though this study was not conducted among older adults.[44] Another recent study that included subjects up to the age of 75 also found a link between GERD and rhinitis symptoms.[45] The exact underlying mechanisms of the GERD-rhinitis association, and whether treatment of GERD will improve rhinitis symptoms in the elderly, deserve further investigation.

Sleep disturbance, and in particular obstructive sleep apnea (OSA), are also common in older adults. Similar to GERD, OSA symptoms increase with age. Among adults over the age of 70, approximately 25% are thought to have OSA – by far higher than any other age group.[46] Two recent studies evaluated the effects of allergic rhinitis treatment for OSA, and both found significant improvements in OSA symptomatology.[47, 48] Underlying mechanisms of the improvement were thought to be related to improvements in nasal inflammation with a resultant decreased nasal obstruction. Although the mean age of the participants in these studies was approximately 49 years, the results may also be applicable to older adults – though again, further studies are needed.

Limited income/poverty

Among older adults, poverty is common. Data from the U.S. Census Bureau found that approximately 10% of older adults lived below the poverty line.[49] Unfortunately, this number has been increasing over the past 10 years due to a variety of factors such as increased medical costs, loss of pension or retirement benefits, spending down assets to qualify for Medicaid and state-sponsored supplemental insurance coverage, and economic recessions requiring spending of retirement savings.[50] Currently, multiple antihistamines and intranasal corticosteroids have moved from prescription to over the counter (OTC) status. One study examining this switch for antihistamines found a 65% decrease in medication utilization,[51] and similar decreases in utilization have been seen in other prescription-to-OTC medication changes. Studies have not been conducted to examine the impact of prescription-to-OTC changes on rhinitis quality of life and symptom control associated with decreased utilization. It is important for the physician caring for older adults with rhinitis to inquire about the ability to afford both prescription and OTC medications, and to offer prescription assistance programs or social work referral as appropriate.

Complementary and alternative medicine for rhinitis among the elderly

Complementary and alternative medicine (CAM) is defined as a group of diverse medical and healthcare systems, practices, and products that are not generally considered part of the conventional allopathic medical practices. Patients often use CAM therapy because of low cost, concerns of medication side effects, belief that adverse effects are not encountered with CAM therapy, and effectiveness (though such claims are often not based on clinical trials).[52] Examples of CAM used for allergic disease include herbal therapies, traditional Chinese medicine, acupuncture, nasal powders and others.

Overall CAM use has been increasing steadily, and 40% of population in the United States has used some form of CAM therapy.[53] Similarly high levels of CAM use for rhinitis have also been seen in both children and adults.[54, 55] Older adults are often more likely than younger adults to use CAM therapy,[56] though this has not been examined specifically in rhinitis therapy. Additionally, older adults with atopic conditions such as asthma rarely tell their physician about CAM use – and physicians typically do not ask.[57] Although CAM use is typically thought to be safe by patients, adverse event monitoring is typically poor, and interactions with allopathic medications can occur. It is therefore important for the physician caring for the older adult with rhinitis to assess CAM utilization, and to work with the patient on a strategy that is both patient-centered and effective.

Dementia, memory loss, and medication compliance in older adults

One cornerstone in the management of a chronic disease such as allergic rhinitis is compliance with a daily medical regiment. Unfortunately, memory loss due to conditions such as dementia and neurovascular complications can make such a task difficult. Dementia and/or memory loss are common among older adults. For adults over the age of 60, approximately 13% note some degree of memory loss;[58] among those over 85, the rate of dementia is a staggering 37%.[59] Additionally, the number of people in the United States with Alzheimer’s dementia is expected to increase dramatically over the next 30 years as the population ages.[60]

Although the different methods of screening an older adult for memory loss and dementia are beyond the scope of this chapter, once such a patient is identified there are steps the physician can do to help maximize medication compliance. These steps include prescribing as few medicines as possible, tailoring dose regimens to personal habits, and coordinating all drug dosing schedules as feasible.[61] The health care provider must assess the patient’s level of self-efficacy and particular living situation when searching for the optimal medication adherence strategy – and at times may need to enlist a family member or other individual to accommodate medication delivery. Along with memory loss, other factors can affect compliance. Poor coordination, hand weakness and arthritis may influence the ability to use nasal sprays. Healthcare providers should review the use of nasal sprays at each visit to ensure proper use.

Treatment of rhinitis in the elderly

Allergic rhinitis

One of the mainstays of allergic rhinitis treatment is avoidance of the offending allergens. In some cases, avoidance may reduce or eliminate the patient’s symptoms. Implementing avoidance measures may be difficult in older adults due to physical limitations to regular cleaning, financial constraints or communal living situations. Older adults living in communal living situations such as nursing homes or assisted living may have little control to make changes in their environmental surroundings.

Second generation antihistamines are standard treatment for mild allergic rhinitis. This class of medications is effective for the symptoms of ocular and nasal pruritus, rhinorrhea and sneezing, but is less effective in reducing nasal congestion[62]. Medications in this class are generally safe in older adults with rhinitis. First-generation antihistamines should be avoided in older adults when possible as they have adverse effects on the central nervous system and interact with other medications. Additionally, studies have shown that the first generation antihistamines can affect driving performance, disturb the normal sleep cycle and impact cognition which can further worsen conditions prevalent in the geriatric population [63, 64]. Topical antihistamines are an alternative to oral antihistamines. They are as effective as oral antihistamines and may reduce nasal congestion more so than oral antihistamines. Azelastine, a topical antihistamine, is well tolerated in older adults with rhinitis [65, 66].

Intranasal corticosteroids (INS) are the first-line therapy for moderate/severe persistent allergic rhinitis[62]. They are effective in reducing all the symptoms of allergic rhinitis including nasal congestion, rhinorrhea and nasal pruritus, but may not be as effective in non-allergic rhinitis. They are generally effective and well tolerated in older adults[67]. Side effects include epistaxis, nasal dryness and mucosal crusting. Patients should be monitored periodically to assess for these adverse effects.

Immunotherapy (IT) is deemed the only treatment that can at least partly modify the natural course of the disease during its initial stages. Its’ use in older adults is still debated. Subcutaneous IT (SCIT) can be considered an effective therapeutic option in otherwise healthy older adults with short disease duration whose symptoms cannot be adequately controlled by medications alone[68, 69]. One study also describes that sublingual IT (SLIT) reduces symptoms, drug consumption and the progression of the disease in both young and older adults allergic to house dust mites, with persistent rhinitis and mild bronchial asthma[70].

Nonallergic rhinitis

Evidence-based guidance for the treatment of NAR in older adults is lacking. The treatment of NAR typically includes the use of INS, topical antihistamines, intranasal anticholinergics, and nasal saline lavage. Intranasal corticosteroids and antihistamines (i.e. azelastine) are recommended for the treatment of persistent NAR [71]. Intranasal corticosteroids have shown improvement in nasal congestion compared to intranasal anticholinergics (ie. ipratropium bromide) in a randomized controlled trial [72]. Due to the wide availability of oral antihistamines, many patients with rhinitis symptoms have tried an oral antihistamine at some point during their course of treatment. As the mechanisms of NAR typically do not involve histamine release it is intuitive to believe that antihistamines have little impact on NAR. There has been no randomized controlled study which has examined the use of antihistamines alone in the treatment of NAR [72]. However, one study from 1982 used a first-generation antihistamine in combination with a decongestant and found an improvement in NAR symptoms with this regimen[73]. As the first-generation antihistamines exhibit significant anti-cholinergic properties, it is likely the antihistamine improved rhinorrhea, while the oral decongestant provided more benefit with nasal congestion. Second-generation antihistamines carry no anti-cholinergic properties, thus explaining the decreased clinical response in NAR.

The topical antihistamines have been shown to be effective in NAR due to the antiinflammatory and neuroinflammatory blockade properties that azelastine and olopatadine exhibit [74]. Studies that have compared topical antihistamines (azelastine, olopatadine) to INSs (fluticasone) found no superiority of either drug in the treatment of NAR[75, 76]. Of importance, when the topical antihistamines azelastine is used in conjunction with intranasal fluticasone, patients have obtained greater symptomatic relief than with the use of either drug alone [77-79].

Although oral decongestants are effective in treating congestion, few studies have examined the use of oral decongestants for the treatment of NAR, especially in the elderly rhinitis population. Two randomized controlled studies using phenylpropanolamine found a decrease in nasal congestion and rhinorrhea though this drug has since been removed from the market[72]. No studies using pseudoephedrine in NAR have been reported. In general, using oral decongestants in elderly patients is ill advised due to concomitant medical problems such as hypertension and cardiac disease. Anticholinergics such as ipratroprium bromide have demonstrated efficacy in reducing rhinorrhea in several randomized controlled trials [80-82]. Despite its’ potent effect on rhinorrhea, it has little effect on the symptom of nasal congestion. This class of medications is best used when the main rhinitis symptom is rhinorrhea as in cold-air induced rhinitis. Moreover, despite the lack of an allergic component in non-allergic rhinitis, environmental controls should be discussed and targeted at irritant triggers such as tobacco smoke, strong odors, and extremes in temperature and humidity.

Mixed Rhinitis

Currently, no treatment is specifically approved by the US Food and Drug Administration (FDA) for the treatment of mixed rhinitis. The standard approach has been to treat patients with this condition similarly to other patients with allergic or non-allergic rhinitis[62]. However, given the effectiveness of azelastine and fluticasone in allergic and non-allergic rhinitis, combined use of these agents is likely to address many of the symptoms associated with this condition.

Atrophic Rhinitis

Treatment of primary and secondary atrophic rhinitis involves reducing crusting and alleviating the foul odor by instituting a regimen of nasal hygiene, such as nasal lavage and crust debridement, and the use of topical and/or systemic antibiotics when purulent secretions or an acute infection is present[83].

Unique medication and treatment concerns in older adults

The selection of medications for the treatment of NAR should take into account that older adults may be more susceptible to adverse effects of many of these medications. Oral first generation antihistamines dosed at bedtime can be effective in NAR for controlling post nasal drainage in contrast to second generation antihistamines that have little to no effect. Adverse effects of first generation antihistamines include urinary retention, dry mouth, constipation, arrhythmias and postural hypertension. Therefore, one needs to carefully monitor for these potential side effects if they are required to treat post nasal drainage unresponsive to topical therapy. Typically, intranasal antihistamines are better tolerated than the oral antihistamines but may not be as effective for drainage.

Intranasal corticosteroids are generally well tolerated. While there is theoretical risk of osteoporosis with high dose INS, studies have failed to show an increase in fractures or bone turnover [84-86]. Healthcare providers should monitor for glaucoma especially if the patient is also taking inhaled or systemic corticosteroids. The impact of INSs on cataract formation is less clear than for intraocular pressure; Derby found no increased risk in cataract formation in a large cohort of INS users[87]. Oral decongestants have sympathomimetic effects which can be of concern in the presence of comorbidities that are known to be more common in older adults, such as hypertension and cardiac disease. Anticholinergic drugs may cause excessive nasal drying and caution should be taken in patients with benign prostatic hypertrophy and narrow-angle glaucoma. In any clinical situation, one must always assess risk of taking a specific drug with benefits and patient preferences.


While there remain significant gaps in our knowledge of rhinitis in older adults (ranging from pathophysiology to prevalence to optimal treatments) there has been significant recent progress (Box 3). With the rise in numbers of older adults in the US population, the magnitude of rhinitis in the elderly will increase. Correct diagnosis of these patients with the appropriate chronic rhinitis subtype is imperative to improve their therapeutic care, minimize rhinitis comorbidities and improve their overall quality of life.

Box 3

Unique issues in treatment of rhinitis among the elderly

  • Symptoms of rhinitis are common, and affect approximately 32% of older adults
  • Nonallergic (including gustatory) and atrophic rhinitis are more common among older adults than younger populations. Determining the rhinitis subtype can help to provide the most appropriate therapy
  • Age related nasal changes and immunosenescence contribute to atrophic rhinitis
  • Comorbidities can affect the presentation of rhinitis, cause medication interactions, and impact compliance. The provider needs to be aware of each comorbidity, and how it may affect rhinitis management
  • Poverty is common among older adults, and can affect the ability of patients to afford therapeutic recommendations
  • Older adults are more likely to use complementary and alternative medication, and rarely tell their physician about it
  • Dementia and memory loss are see in 13% above the age of 60, and affect the ability of a patient to manage a chronic disease like rhinitis. Screening for memory loss may be appropriate
  • Medication side effects are far more common in older adults. The provider should be aware of adverse drug effects for each medication a patient is on

Key points

  1. Symptoms of rhinitis are common, and affect approximately 32% of older adults.
  2. Nonallergic and atrophic rhinitis are more common among older adults than younger populations. Determining the rhinitis subtype can help to provide the most appropriate therapy.
  3. Although treatment options for rhinitis exist, special considerations need to be made as comorbidities, limited income, memory loss, and side effects of medications frequently occur in older adults and may impact outcomes.


Funding support : National Institute of Aging (NIA) 1 R01 AG043401-01A1


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