Search tips
Search criteria 


Logo of brheartjLink to Publisher's site
Br Heart J. 1976 January; 38(1): 77–80.
PMCID: PMC482973

Sustained release procainamide in patients with myocardial infarction.


Sustained release procainamide tablets were administered to 34 patients 48 hours after the onset of an acute myocardial infarct. Therapeutic blood levels of procainamide in the range of 4 to 8 mug/ml were consistently achieved using an 8-hourly maintenance dose of 1.5g after an initial loading dose of 2g. In contrast conventional procainamide capsules administered to 21 comparable patients repeatedly failed to produce plasma concentrations in the therapeutic range, despite the administration of a maintenance dose of 375 mg 3 hourly, after a loading dose of 1g. It is suggested that when the oral administration of procainamide is indicated for the management of ventricular arrhythmias after myocardial infarction, a sustained release preparation should be used.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (587K), or click on a page image below to browse page by page.

Articles from British Heart Journal are provided here courtesy of BMJ Group