PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of brheartjLink to Publisher's site
 
Br Heart J. 1975 November; 37(11): 1191–1194.
PMCID: PMC482938

Candida endocarditis treated with a combination of antifungal chemotherapy and aortic valve replacement.

Abstract

A case of Candida albicans endocarditis is described in which treatment with 5-fluorocytosine was started after aortic valve replacement, but relapse followed discontinuance of treatment. At a second operation the aortic valve was replaced under 5-fluorocytosine cover and treatment was continued with both 5-fluorocytosine and amphotericin-B. No resistance to 5-fluorocytosine developed, and the candida infection was eradicated. The patient is well 22 months after his operation.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (573K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Block ER, Bennett JE. Pharmacological studies with 5-fluorocytosine. Antimicrob Agents Chemother. 1972 Jun;1(6):476–482. [PMC free article] [PubMed]
  • Block ER, Bennett JE. The combined effect of 5-fluorocytosine and amphotericin B in the therapy of murine cryptococcosis. Proc Soc Exp Biol Med. 1973 Feb;142(2):476–480. [PubMed]
  • Drutz DJ, Spickard A, Rogers DE, Koenig MG. Treatment of disseminated mycotic infectioons. A new approach to amphotericin B therapy. Am J Med. 1968 Sep;45(3):405–418. [PubMed]
  • Harris PD, Yeoh CB, Breault J, Meltzer J, Katz S. Fungal endocarditis secondary to drug addiction. Recent concepts in diagnosis and therapy. J Thorac Cardiovasc Surg. 1972 Jun;63(6):980–985. [PubMed]
  • Kay JH, Berstein S, Tsuji HK, Redington JV, Milgram M, Brem T. Surgical treatment of candida endocarditis. JAMA. 1968 Feb 26;203(9):621–626. [PubMed]
  • Logan RL, Goldberg MJ. C. albicans resistance to 5-fluorocytosine. Br Med J. 1972 Aug 26;3(5825):531–531. [PMC free article] [PubMed]
  • Medoff G, Comfort M, Kobayashi GS. Synergistic action of amphotericin B and 5-fluorocytosine against yeast-like organisms. Proc Soc Exp Biol Med. 1971 Nov;138(2):571–574. [PubMed]
  • Medoff G, Kobayashi GS, Kwan CN, Schlessinger D, Venkov P. Potentiation of rifampicin and 5-fluorocytosine as antifungal antibiotics by amphotericin B (yeast-membrane permeability-ribosomal RNA-eukaryotic cell-synergism). Proc Natl Acad Sci U S A. 1972 Jan;69(1):196–199. [PubMed]
  • Record CO, Skinner JM, Sleight P, Speller DC. Candida endocarditis treated with 5-fluorocytosine. Br Med J. 1971 Jan 30;1(5743):262–264. [PMC free article] [PubMed]
  • Seelig MS, Speth CP, Kozinn PJ, Taschdjian CL, Toni EF, Goldberg P. Patterns of Candida endocarditis following cardiac surgery: Importance of early diagnosis and therapy (an analysis of 91 cases). Prog Cardiovasc Dis. 1974 Sep-Oct;17(2):125–160. [PubMed]
  • Seelig MS, Speth CP, Kozinn PJ, Toni EF, Taschdjian CL. Candida endocarditis after cardiac surgery. Clues to earlier detection. J Thorac Cardiovasc Surg. 1973 Apr;65(4):583–601. [PubMed]

Articles from British Heart Journal are provided here courtesy of BMJ Group