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Br Heart J. 1975 November; 37(11): 1191–1194.
PMCID: PMC482938

Candida endocarditis treated with a combination of antifungal chemotherapy and aortic valve replacement.


A case of Candida albicans endocarditis is described in which treatment with 5-fluorocytosine was started after aortic valve replacement, but relapse followed discontinuance of treatment. At a second operation the aortic valve was replaced under 5-fluorocytosine cover and treatment was continued with both 5-fluorocytosine and amphotericin-B. No resistance to 5-fluorocytosine developed, and the candida infection was eradicated. The patient is well 22 months after his operation.

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Selected References

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  • Block ER, Bennett JE. Pharmacological studies with 5-fluorocytosine. Antimicrob Agents Chemother. 1972 Jun;1(6):476–482. [PMC free article] [PubMed]
  • Block ER, Bennett JE. The combined effect of 5-fluorocytosine and amphotericin B in the therapy of murine cryptococcosis. Proc Soc Exp Biol Med. 1973 Feb;142(2):476–480. [PubMed]
  • Drutz DJ, Spickard A, Rogers DE, Koenig MG. Treatment of disseminated mycotic infectioons. A new approach to amphotericin B therapy. Am J Med. 1968 Sep;45(3):405–418. [PubMed]
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  • Logan RL, Goldberg MJ. C. albicans resistance to 5-fluorocytosine. Br Med J. 1972 Aug 26;3(5825):531–531. [PMC free article] [PubMed]
  • Medoff G, Comfort M, Kobayashi GS. Synergistic action of amphotericin B and 5-fluorocytosine against yeast-like organisms. Proc Soc Exp Biol Med. 1971 Nov;138(2):571–574. [PubMed]
  • Medoff G, Kobayashi GS, Kwan CN, Schlessinger D, Venkov P. Potentiation of rifampicin and 5-fluorocytosine as antifungal antibiotics by amphotericin B (yeast-membrane permeability-ribosomal RNA-eukaryotic cell-synergism). Proc Natl Acad Sci U S A. 1972 Jan;69(1):196–199. [PubMed]
  • Record CO, Skinner JM, Sleight P, Speller DC. Candida endocarditis treated with 5-fluorocytosine. Br Med J. 1971 Jan 30;1(5743):262–264. [PMC free article] [PubMed]
  • Seelig MS, Speth CP, Kozinn PJ, Taschdjian CL, Toni EF, Goldberg P. Patterns of Candida endocarditis following cardiac surgery: Importance of early diagnosis and therapy (an analysis of 91 cases). Prog Cardiovasc Dis. 1974 Sep-Oct;17(2):125–160. [PubMed]
  • Seelig MS, Speth CP, Kozinn PJ, Toni EF, Taschdjian CL. Candida endocarditis after cardiac surgery. Clues to earlier detection. J Thorac Cardiovasc Surg. 1973 Apr;65(4):583–601. [PubMed]

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