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Intensive Care Med Exp. 2015 December; 3(Suppl 1): A423.
Published online 2015 October 1. doi:  10.1186/2197-425X-3-S1-A423
PMCID: PMC4798309

Conservative versus liberal oxygenation targets for mechanically ventilated patients: pilot multicentre randomised trial

L Barrot, R Panwar, M Hardie, R Bellomo, G Eastwood, P Young, P Harrigan, M Bailey, G Capellier,corresponding author and CLOSE Study Investigators and the ANZICS Clinical Trials Group

Introduction

There is now increasing recognition of potential harm due to hyperoxia. Conventional practice of oxygen therapy often result in hyperoxia. Nearly all patients on mechanical ventilation receive supplemental oxygen therapy. However, RCTs investigating the effects of different oxygenation level during MV are lacking

Objectives

We aim to systematically evaluate whether liberal oxygenation strategy is beneficial or harmful compared to conservative oxygenation strategy for patients on invasive MV.

Methods

Patients likely to require 48 hours of MV, older than 18 years were included. Prospective trial conducted in 4 university affiliated ICU in Australia, New Zealand and France. Enrolled patients were randomly allocated to either liberal or conservative oxygenation arm(SaO2/SpO2 >96% or between 88-92% respectively) and followed until day 90. The bedside nurse titrated FiO2 to reach the oxygenation target.

Results

357 patients were screened and 104 were enrolled, 53 and 51 respectively in conservative and liberal arm respectively. Patients characteristics were similar at baseline. ABG’s were checked more often in the conservative arm. Using an hypoxemia threshold of SpO2 < 88%, 1% and 0.3% of the values in the conservative and liberal arm respectively were in hypoxemic range. With a PaO2 threshold < 55 mmHg, 7% and 1% respectively of the values were in hypoxemic range. With a threshold of SpO2>98% while FiO2 > 0.21, 4% and 22% of SpO2 values respectively were in the hyperoxic range. Same difference were found when using an hyperoxic threshold of PaO2>120 mmHg (p < 0.05 for all comparison). Participants spent majority of time within the intended target range in both groups. Mean AUC and 95%CI for SpO2, SaO2, PaO2 and FiO2 were significantly lower in the conservative group compared to liberal group. Survival analysis curve were similar for both groups (OR 0.77 (95%CI:0.4-1.50; p = 0.44)). For patients with a P/F ratio < 300, the separation in mean FiO2 was wider between the two arms. Outcome were similar. There slightly more arrhythmia-free days in the conservative arm. In thisP/F < 300 subgroup, the adjusted hazard ratio for death by day 90 was lower in the conservative arm compared to liberal arm.

Conclusions

Our study demonstrate that conservative oxygenation strategy is a feasible and safe alternative to the usual liberal oxygenation strategy.

Grant Acknowledgment

Intensive Care Foundation (ANZ), University Hospital Besançon (France) and Don Du Souffle (France).

References

1. Damiani E, Adrario E, Girardis M, Romano R, Pelaia P, Singer M, Donati A. Arterial hyperoxia and mortality in critically ill patients: a systematic review and meta-analysis. Crit Care. 2014;18(6):711. doi: 10.1186/s13054-014-0711-x. [PMC free article] [PubMed] [Cross Ref]
2. Panwar R, Capellier G, Schmutz N, Davies A, Cooper DJ, Bailey M, et al. Current oxygenation practice in ventilated patients-an observational cohort study. Anaesth Intensive Care. 2013;41(4):505–514. [PubMed]

Articles from Intensive Care Medicine Experimental are provided here courtesy of Springer-Verlag